AutismKB 2.0

Annotation Detail for CNOT3


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Basic Information Top
Gene Symbol:CNOT3 ( KIAA0691,LENG2,NOT3,NOT3H )
Gene Full Name: CCR4-NOT transcription complex, subunit 3
Band: 19q13.42
Quick LinksEntrez ID:4849; OMIM: 604910; Uniprot ID:CNOT3_HUMAN; ENSEMBL ID: ENSG00000088038; HGNC ID: 7879
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body7 / 7076198
blastocyst11 / 62319176
fetus35 / 56401262
neonate2 / 3109764
infant1 / 2362042
juvenile1 / 5555617
adult102 / 193912152
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma3 / 17475171
breast (mammary gland) tumor3 / 9417831
cervical tumor0 / 343660 
chondrosarcoma3 / 8282336
colorectal tumor9 / 11424678
esophageal tumor0 / 172900 
gastrointestinal tumor11 / 11936992
germ cell tumor21 / 26384579
glioma14 / 106883130
head and neck tumor14 / 136302102
kidney tumor3 / 6895943
leukemia1 / 9584210
liver tumor4 / 9635941
lung tumor6 / 10312758
lymphoma5 / 7175569
non-neoplasia2 / 9725020
normal138 / 336030741
ovarian tumor7 / 7668291
pancreatic tumor4 / 10461638
primitive neuroectodermal tumor of the CNS6 / 12568047
prostate cancer6 / 10268058
retinoblastoma2 / 4635643
skin tumor21 / 124949168
soft tissue/muscle tissue tumor7 / 12519155
uterine tumor9 / 9025799
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites2 / 4001549
bladder3 / 29757100
blood2 / 12347816
bone2 / 7165527
bone marrow0 / 488010 
brain58 / 110098952
cervix0 / 481710 
connective tissue3 / 14925520
ear0 / 162120 
embryonic tissue21 / 21572297
esophagus0 / 202090 
eye12 / 21105456
heart4 / 8962644
intestine19 / 23447281
kidney8 / 21177737
larynx6 / 24145248
liver7 / 20774333
lung15 / 33697444
lymph3 / 4427067
lymph node3 / 9161032
mammary gland4 / 15327126
mouth5 / 6705274
muscle0 / 1077150 
nerve1 / 1576863
ovary16 / 102051156
pancreas8 / 21481237
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland2 / 16585120
placenta5 / 28082517
prostate10 / 18934552
salivary gland1 / 2015549
skin22 / 210574104
spleen1 / 5395218
stomach8 / 9661982
testis7 / 33044221
thymus9 / 81131110
thyroid4 / 4747384
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord0 / 136800 
uterus18 / 23287877
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 203239_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts106.2
Adipocyte11.6
AdrenalCortex16.9
Adrenalgland13.1
Amygdala22.05
Appendix13.15
AtrioventricularNode8.15
BDCA4+_DentriticCells23.6
Bonemarrow11.3
BronchialEpithelialCells10.75
CD105+_Endothelial10.6
CD14+_Monocytes16.2
CD19+_BCells(neg._sel.)22.9
CD33+_Myeloid13.5
CD34+13.4
CD4+_Tcells18.95
CD56+_NKCells12.4
CD71+_EarlyErythroid11.15
CD8+_Tcells20.65
CardiacMyocytes19.6
Caudatenucleus10.8
Cerebellum16.65
CerebellumPeduncles14.8
CiliaryGanglion5.2
CingulateCortex14.85
Colorectaladenocarcinoma77.6
DorsalRootGanglion9.3
FetalThyroid12.15
Fetalbrain10.5
Fetalliver7.5
Fetallung11.1
GlobusPallidus6.35
Heart22.95
Hypothalamus11.9
Kidney10.6
Leukemia_chronicMyelogenousK-56226.4
Leukemia_promyelocytic-HL-6014.7
Leukemialymphoblastic(MOLT-4)40.7
Liver28.9
Lung37.15
Lymphnode10
Lymphoma_burkitts(Daudi)16.65
Lymphoma_burkitts(Raji)102.5
MedullaOblongata11.9
OccipitalLobe10.8
OlfactoryBulb8.95
Ovary11.75
Pancreas9.3
PancreaticIslet11.8
ParietalLobe14
Pituitary14
Placenta25.45
Pons22.75
PrefrontalCortex35.65
Prostate26.85
Salivarygland8.85
SkeletalMuscle18.8
Skin8.75
SmoothMuscle13.9
Spinalcord12.65
SubthalamicNucleus10.75
SuperiorCervicalGanglion17.1
TemporalLobe11
Testis29.6
TestisGermCell79.8
TestisIntersitial38.4
TestisLeydigCell29
TestisSeminiferousTubule20.1
Thalamus10
Thymus23.55
Thyroid38.45
Tongue13.7
Tonsil12
Trachea9.45
TrigeminalGanglion11.1
Uterus10.7
UterusCorpus13.35
WholeBlood85.9
Wholebrain12.7
colon11
pineal_day30.24
pineal_night21.54
retina19.525
small_intestine11.3
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_1687_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.26 ± 0.75
Basal Forebrain3.12 ± 0.5
Basal Part of Pons3.35 ± 0.63
Cerebellar Cortex3.7 ± 0.38
Cerebellar Nuclei3.12 ± 0.52
Claustrum2.98 ± 0.6
Epithalamus3.13 ± 0.63
Frontal Lobe3.28 ± 0.66
Globus Pallidus2.42 ± 0.77
Hypothalamus2.87 ± 0.57
Insula3.55 ± 0.38
Limbic Lobe3.2 ± 0.6
Mesencephalon3.3 ± 0.87
Myelencephalon3.23 ± 0.61
Occipital Lobe2.99 ± 0.65
Parietal Lobe3.14 ± 0.61
Pontine Tegmentum3.17 ± 0.61
Striatum2.66 ± 0.75
Subthalamus3.22 ± 0.6
Temporal Lobe3.36 ± 0.63
Thalamus3.13 ± 0.6
White Matter3.3 ± 0.23
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Cnot3LSXLateral septal complex90.22
62.01
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00062906 19 517 535 AAGALLNGPPQFSTAPEIK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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