AutismKB 2.0

Annotation Detail for NOTCH4


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Basic Information Top
Gene Symbol:NOTCH4 ( FLJ16302,INT3,MGC74442,NOTCH3 )
Gene Full Name: notch 4
Band: 6p21.32
Quick LinksEntrez ID:4855; OMIM: 164951; Uniprot ID:NOTC4_HUMAN; ENSEMBL ID: ENSG00000204301; HGNC ID: 7884
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus13 / 56401223
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult43 / 193912122
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor4 / 26384515
glioma2 / 10688318
head and neck tumor2 / 13630214
kidney tumor1 / 6895914
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor5 / 10312748
lymphoma0 / 717550 
non-neoplasia6 / 9725061
normal87 / 336030725
ovarian tumor1 / 7668213
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS2 / 12568015
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites0 / 400150 
bladder1 / 2975733
blood1 / 1234788
bone1 / 7165513
bone marrow0 / 488010 
brain29 / 110098926
cervix0 / 481710 
connective tissue2 / 14925513
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye0 / 2110540 
heart2 / 8962622
intestine2 / 2344728
kidney4 / 21177718
larynx1 / 2414541
liver0 / 2077430 
lung13 / 33697438
lymph0 / 442700 
lymph node2 / 9161021
mammary gland5 / 15327132
mouth1 / 6705214
muscle2 / 10771518
nerve1 / 1576863
ovary2 / 10205119
pancreas6 / 21481227
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta12 / 28082542
prostate2 / 18934510
salivary gland0 / 201550 
skin1 / 2105744
spleen2 / 5395237
stomach0 / 966190 
testis2 / 3304426
thymus2 / 8113124
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus3 / 23287812
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 205247_at
Cell line Expression level Expression bar
721_B_lymphoblasts48.65
Adipocyte87.05
AdrenalCortex118.2
Adrenalgland94.9
Amygdala97.45
Appendix131.7
AtrioventricularNode96.6
BDCA4+_DentriticCells137.05
Bonemarrow100.45
BronchialEpithelialCells68.65
CD105+_Endothelial91.65
CD14+_Monocytes70.7
CD19+_BCells(neg._sel.)71.6
CD33+_Myeloid96.55
CD34+47.1
CD4+_Tcells55.55
CD56+_NKCells73.5
CD71+_EarlyErythroid72.2
CD8+_Tcells59.45
CardiacMyocytes139.5
Caudatenucleus84.9
Cerebellum101.55
CerebellumPeduncles116.5
CiliaryGanglion100.6
CingulateCortex116.95
Colorectaladenocarcinoma90.4
DorsalRootGanglion92.95
FetalThyroid105.8
Fetalbrain101.4
Fetalliver84.45
Fetallung146.8
GlobusPallidus73.2
Heart191.15
Hypothalamus108.85
Kidney92.3
Leukemia_chronicMyelogenousK-56279.65
Leukemia_promyelocytic-HL-6070.6
Leukemialymphoblastic(MOLT-4)70.5
Liver128.7
Lung188.9
Lymphnode74.05
Lymphoma_burkitts(Daudi)121.6
Lymphoma_burkitts(Raji)134.3
MedullaOblongata86.25
OccipitalLobe83.8
OlfactoryBulb74.5
Ovary77.05
Pancreas87.2
PancreaticIslet156.75
ParietalLobe111.6
Pituitary110.85
Placenta117.65
Pons111.25
PrefrontalCortex115.25
Prostate121.05
Salivarygland72.65
SkeletalMuscle157.65
Skin78.1
SmoothMuscle88.5
Spinalcord99.1
SubthalamicNucleus74.45
SuperiorCervicalGanglion188.55
TemporalLobe148.95
Testis80.7
TestisGermCell77
TestisIntersitial79.35
TestisLeydigCell96.75
TestisSeminiferousTubule87.2
Thalamus98.15
Thymus59.75
Thyroid127.25
Tongue103.55
Tonsil88.95
Trachea78.55
TrigeminalGanglion122.15
Uterus76.35
UterusCorpus112.75
WholeBlood90.4
Wholebrain86.4
colon93.8
pineal_day80.32
pineal_night75.04
retina149.5
small_intestine89.8
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P26496
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.46 ± 0.49
Basal Forebrain4.5 ± 0.4
Basal Part of Pons4.9 ± 0.31
Cerebellar Cortex4.78 ± 0.4
Cerebellar Nuclei4.56 ± 0.49
Claustrum4.33 ± 0.65
Epithalamus4.32 ± 0.5
Frontal Lobe4.44 ± 0.46
Globus Pallidus5.01 ± 0.48
Hypothalamus4.48 ± 0.22
Insula4.45 ± 0.35
Limbic Lobe4.51 ± 0.53
Mesencephalon4.43 ± 0.46
Myelencephalon4.55 ± 0.49
Occipital Lobe4.56 ± 0.44
Parietal Lobe4.49 ± 0.42
Pontine Tegmentum4.4 ± 0.45
Striatum4.34 ± 0.53
Subthalamus4.68 ± 0.48
Temporal Lobe4.54 ± 0.47
Thalamus4.64 ± 0.45
White Matter5.03 ± 0.3
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Notch4CBCerebellum0
0
Notch4CTXCerebral cortex0
0
Notch4HIPHippocampal region0
0
Notch4HPFHippocampal formation0
0
Notch4HYHypothalamus0
0
Notch4LSXLateral septal complex0
0
Notch4MBMidbrain0
0
Notch4MYMedulla0
0
Notch4OLFOlfactory bulb0
0
Notch4PPons0
0
Notch4PALPallidum0
0
Notch4RHPRetrohippocampal region0
0
Notch4sAMYStriatum-like amygdalar nuclei0
0
Notch4STRStriatum0
0
Notch4STRdStriatum dorsal region0
0
Notch4STRvStriatum ventral region0
0
Notch4THThalamus0
0
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
NOTC4_HUMAN_1405 6 1405 1410 PGLLLR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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