AutismKB 2.0

Annotation Detail for NPPA


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Basic Information Top
Gene Symbol:NPPA ( ANF,ANP,ATFB6,CDD-ANF,PND )
Gene Full Name: natriuretic peptide precursor A
Band: 1p36.22
Quick LinksEntrez ID:4878; OMIM: 108780; Uniprot ID:ANF_HUMAN; ENSEMBL ID: ENSG00000175206; HGNC ID: 7939
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus150 / 564012265
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult22 / 193912111
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor0 / 2638450 
glioma4 / 10688337
head and neck tumor0 / 1363020 
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal177 / 336030752
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor3 / 12519123
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain4 / 11009893
cervix0 / 481710 
connective tissue3 / 14925520
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye2 / 2110549
heart180 / 896262008
intestine0 / 2344720 
kidney0 / 2117770 
larynx0 / 241450 
liver0 / 2077430 
lung38 / 336974112
lymph0 / 442700 
lymph node0 / 916100 
mammary gland0 / 1532710 
mouth0 / 670520 
muscle0 / 1077150 
nerve0 / 157680 
ovary0 / 1020510 
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate1 / 1893455
salivary gland0 / 201550 
skin0 / 2105740 
spleen0 / 539520 
stomach0 / 966190 
testis1 / 3304423
thymus1 / 8113112
thyroid0 / 474730 
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord0 / 136800 
uterus2 / 2328788
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 209957_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts24.25
Adipocyte38.5
AdrenalCortex40.35
Adrenalgland35.75
Amygdala56.1
Appendix50.6
AtrioventricularNode36.45
BDCA4+_DentriticCells22.2
Bonemarrow48.25
BronchialEpithelialCells24.5
CD105+_Endothelial34.75
CD14+_Monocytes22.25
CD19+_BCells(neg._sel.)22.35
CD33+_Myeloid35.3
CD34+37.25
CD4+_Tcells37.6
CD56+_NKCells28.65
CD71+_EarlyErythroid35.45
CD8+_Tcells25.2
CardiacMyocytes39.8
Caudatenucleus44.6
Cerebellum31.95
CerebellumPeduncles62
CiliaryGanglion28.45
CingulateCortex44.1
Colorectaladenocarcinoma40.3
DorsalRootGanglion34.8
FetalThyroid55
Fetalbrain42.25
Fetalliver41.3
Fetallung56.05
GlobusPallidus28.35
Heart2573.5
Hypothalamus40.9
Kidney48.2
Leukemia_chronicMyelogenousK-56235.1
Leukemia_promyelocytic-HL-6032.1
Leukemialymphoblastic(MOLT-4)31.6
Liver50.8
Lung39.85
Lymphnode36.95
Lymphoma_burkitts(Daudi)51.75
Lymphoma_burkitts(Raji)48.65
MedullaOblongata44.85
OccipitalLobe36.6
OlfactoryBulb32.15
Ovary31.4
Pancreas31.4
PancreaticIslet41.8
ParietalLobe48.65
Pituitary44.5
Placenta36.5
Pons62.45
PrefrontalCortex45.45
Prostate43.1
Salivarygland43.95
SkeletalMuscle62.2
Skin32.15
SmoothMuscle33.3
Spinalcord41.7
SubthalamicNucleus49.85
SuperiorCervicalGanglion62.35
TemporalLobe42.3
Testis34.25
TestisGermCell31.55
TestisIntersitial32.8
TestisLeydigCell39.6
TestisSeminiferousTubule36
Thalamus59.6
Thymus24.35
Thyroid48.6
Tongue44.1
Tonsil38.1
Trachea45.15
TrigeminalGanglion59.6
Uterus23.25
UterusCorpus40.2
WholeBlood25.65
Wholebrain34.4
colon40.95
pineal_day38.36
pineal_night35.06
retina50.3
small_intestine45.95
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_16295_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.83 ± 0.94
Basal Forebrain3.42 ± 0.41
Basal Part of Pons3.31 ± 0.78
Cerebellar Cortex3.22 ± 0.61
Cerebellar Nuclei3.64 ± 0.62
Claustrum3.55 ± 0.82
Epithalamus3.24 ± 0.64
Frontal Lobe3.72 ± 0.8
Globus Pallidus3.45 ± 1.3
Hypothalamus3.45 ± 0.74
Insula4.28 ± 0.54
Limbic Lobe3.59 ± 0.75
Mesencephalon3.66 ± 0.8
Myelencephalon3.66 ± 0.85
Occipital Lobe2.84 ± 0.92
Parietal Lobe3.62 ± 0.67
Pontine Tegmentum3.54 ± 0.83
Striatum2.66 ± 1
Subthalamus4.15 ± 1.36
Temporal Lobe4.15 ± 0.58
Thalamus3.39 ± 0.71
White Matter2.37 ± 0.07
Mouse Brain ISH
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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