AutismKB 2.0

Annotation Detail for SLC11A2


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Basic Information Top
Gene Symbol:SLC11A2 ( DCT1,DMT1,FLJ37416,NRAMP2 )
Gene Full Name: solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
Band: 12q13.12
Quick LinksEntrez ID:4891; OMIM: 600523; Uniprot ID:NRAM2_HUMAN; ENSEMBL ID: ENSG00000110911; HGNC ID: 10908
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body7 / 7076198
blastocyst5 / 6231980
fetus60 / 564012106
neonate5 / 31097160
infant3 / 23620127
juvenile6 / 55556107
adult179 / 193912192
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma1 / 1747557
breast (mammary gland) tumor10 / 94178106
cervical tumor2 / 3436658
chondrosarcoma8 / 8282396
colorectal tumor15 / 114246131
esophageal tumor3 / 17290173
gastrointestinal tumor4 / 11936933
germ cell tumor37 / 263845140
glioma1 / 1068839
head and neck tumor10 / 13630273
kidney tumor7 / 68959101
leukemia3 / 9584231
liver tumor5 / 9635951
lung tumor5 / 10312748
lymphoma4 / 7175555
non-neoplasia9 / 9725092
normal360 / 3360307107
ovarian tumor0 / 766820 
pancreatic tumor3 / 10461628
primitive neuroectodermal tumor of the CNS15 / 125680119
prostate cancer11 / 102680107
retinoblastoma5 / 46356107
skin tumor6 / 12494948
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor12 / 90257132
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites2 / 4001549
bladder5 / 29757168
blood6 / 12347848
bone4 / 7165555
bone marrow3 / 4880161
brain203 / 1100989184
cervix2 / 4817141
connective tissue7 / 14925546
ear0 / 162120 
embryonic tissue15 / 21572269
esophagus3 / 20209148
eye16 / 21105475
heart0 / 896260 
intestine18 / 23447276
kidney14 / 21177766
larynx0 / 241450 
liver7 / 20774333
lung29 / 33697486
lymph0 / 442700 
lymph node2 / 9161021
mammary gland10 / 15327165
mouth9 / 67052134
muscle8 / 10771574
nerve1 / 1576863
ovary1 / 1020519
pancreas8 / 21481237
parathyroid2 / 2053997
pharynx3 / 4132872
pituitary gland1 / 1658560
placenta40 / 280825142
prostate12 / 18934563
salivary gland2 / 2015599
skin18 / 21057485
spleen3 / 5395255
stomach1 / 9661910
testis52 / 330442157
thymus16 / 81131197
thyroid2 / 4747342
tonsil0 / 169990 
trachea31 / 52413591
umbilical cord0 / 136800 
uterus30 / 232878128
vascular6 / 51780115
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 210047_at
Cell line Expression level Expression bar
721_B_lymphoblasts8.25
Adipocyte7.9
AdrenalCortex11.6
Adrenalgland7.3
Amygdala7.6
Appendix13.3
AtrioventricularNode9.35
BDCA4+_DentriticCells8.65
Bonemarrow8.9
BronchialEpithelialCells7.5
CD105+_Endothelial8.6
CD14+_Monocytes8.9
CD19+_BCells(neg._sel.)8.65
CD33+_Myeloid13.65
CD34+10.55
CD4+_Tcells7.95
CD56+_NKCells10
CD71+_EarlyErythroid7.9
CD8+_Tcells7.15
CardiacMyocytes10.2
Caudatenucleus7.25
Cerebellum6.75
CerebellumPeduncles10
CiliaryGanglion7.2
CingulateCortex8.75
Colorectaladenocarcinoma8.15
DorsalRootGanglion8.35
FetalThyroid9
Fetalbrain7.65
Fetalliver6.9
Fetallung6.9
GlobusPallidus6.65
Heart10.2
Hypothalamus8.05
Kidney7.85
Leukemia_chronicMyelogenousK-5627.05
Leukemia_promyelocytic-HL-606.95
Leukemialymphoblastic(MOLT-4)6.35
Liver13.4
Lung8.9
Lymphnode6.45
Lymphoma_burkitts(Daudi)10.5
Lymphoma_burkitts(Raji)12.45
MedullaOblongata7.2
OccipitalLobe7.1
OlfactoryBulb6.85
Ovary7.2
Pancreas6.55
PancreaticIslet8.95
ParietalLobe9.15
Pituitary9.6
Placenta8
Pons8.2
PrefrontalCortex9.75
Prostate9.45
Salivarygland7.35
SkeletalMuscle17.7
Skin10.7
SmoothMuscle9.2
Spinalcord8.6
SubthalamicNucleus8.05
SuperiorCervicalGanglion22.65
TemporalLobe8.2
Testis7.05
TestisGermCell6.95
TestisIntersitial7.35
TestisLeydigCell8.4
TestisSeminiferousTubule7
Thalamus8.4
Thymus6.35
Thyroid10.35
Tongue9.45
Tonsil8.1
Trachea6.75
TrigeminalGanglion12.7
Uterus6.15
UterusCorpus11.05
WholeBlood8.3
Wholebrain6.4
colon7.95
pineal_day9.78
pineal_night9.52
retina9.95
small_intestine7.65
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P139820
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.21 ± 0.36
Basal Forebrain7.45 ± 0.25
Basal Part of Pons7.78 ± 0.48
Cerebellar Cortex7.7 ± 0.26
Cerebellar Nuclei7.81 ± 0.25
Claustrum7.12 ± 0.46
Epithalamus7.73 ± 0.35
Frontal Lobe7.54 ± 0.36
Globus Pallidus7.44 ± 0.28
Hypothalamus7.74 ± 0.24
Insula7.4 ± 0.34
Limbic Lobe7.32 ± 0.42
Mesencephalon7.4 ± 0.44
Myelencephalon7.47 ± 0.42
Occipital Lobe7.44 ± 0.43
Parietal Lobe7.5 ± 0.37
Pontine Tegmentum7.44 ± 0.33
Striatum7.1 ± 0.32
Subthalamus7.49 ± 0.16
Temporal Lobe7.47 ± 0.33
Thalamus7.6 ± 0.37
White Matter8.78 ± 0.12
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Slc11a2CBCerebellum3.4
2.51
Slc11a2CTXCerebral cortex0.88
0.66
Slc11a2HIPHippocampal region1.7
0.81
Slc11a2HPFHippocampal formation1.43
0.72
Slc11a2HYHypothalamus2.18
1.13
Slc11a2LSXLateral septal complex0.18
0.12
Slc11a2MBMidbrain1.67
1.16
Slc11a2MYMedulla14.63
10.31
Slc11a2OLFOlfactory bulb1.65
1.33
Slc11a2PPons7.73
5.42
Slc11a2PALPallidum1.4
0.82
Slc11a2RHPRetrohippocampal region0.91
0.55
Slc11a2sAMYStriatum-like amygdalar nuclei0.85
0.76
Slc11a2STRStriatum0.45
0.33
Slc11a2STRdStriatum dorsal region0.28
0.26
Slc11a2STRvStriatum ventral region1.19
0.57
Slc11a2THThalamus1.16
0.63
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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