AutismKB 2.0

Annotation Detail for NRGN


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Basic Information Top
Gene Symbol:NRGN ( RC3,hng )
Gene Full Name: neurogranin (protein kinase C substrate, RC3)
Band: 11q24.2
Quick LinksEntrez ID:4900; OMIM: 602350; Uniprot ID:NEUG_HUMAN; ENSEMBL ID: ENSG00000154146; HGNC ID: 8000
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst1 / 6231916
fetus10 / 56401217
neonate0 / 310970 
infant0 / 236200 
juvenile2 / 5555635
adult143 / 193912173
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma4 / 8282348
colorectal tumor2 / 11424617
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor7 / 26384526
glioma9 / 10688384
head and neck tumor1 / 1363027
kidney tumor0 / 689590 
leukemia5 / 9584252
liver tumor0 / 963590 
lung tumor1 / 1031279
lymphoma0 / 717550 
non-neoplasia2 / 9725020
normal162 / 336030748
ovarian tumor4 / 7668252
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor1 / 1249498
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites0 / 400150 
bladder0 / 297570 
blood3 / 12347824
bone3 / 7165541
bone marrow0 / 488010 
brain147 / 1100989133
cervix0 / 481710 
connective tissue2 / 14925513
ear0 / 162120 
embryonic tissue1 / 2157224
esophagus0 / 202090 
eye7 / 21105433
heart0 / 896260 
intestine4 / 23447217
kidney1 / 2117774
larynx0 / 241450 
liver0 / 2077430 
lung6 / 33697417
lymph0 / 442700 
lymph node1 / 9161010
mammary gland0 / 1532710 
mouth0 / 670520 
muscle0 / 1077150 
nerve0 / 157680 
ovary4 / 10205139
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate0 / 1893450 
salivary gland0 / 201550 
skin1 / 2105744
spleen0 / 539520 
stomach0 / 966190 
testis2 / 3304426
thymus0 / 811310 
thyroid1 / 4747321
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus3 / 23287812
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 204081_at
Cell line Expression level Expression bar
721_B_lymphoblasts24.65
Adipocyte15.65
AdrenalCortex16.05
Adrenalgland15.7
Amygdala7078.35
Appendix18
AtrioventricularNode11.9
BDCA4+_DentriticCells65.8
Bonemarrow125
BronchialEpithelialCells14.85
CD105+_Endothelial18
CD14+_Monocytes1577.55
CD19+_BCells(neg._sel.)167.6
CD33+_Myeloid424.65
CD34+52.25
CD4+_Tcells17.65
CD56+_NKCells21.6
CD71+_EarlyErythroid15.85
CD8+_Tcells12.7
CardiacMyocytes21.4
Caudatenucleus8531.2
Cerebellum14.45
CerebellumPeduncles19.7
CiliaryGanglion11.25
CingulateCortex7864.55
Colorectaladenocarcinoma18.6
DorsalRootGanglion8.95
FetalThyroid19.7
Fetalbrain886.3
Fetalliver38.9
Fetallung163
GlobusPallidus4640.45
Heart119.4
Hypothalamus155.4
Kidney15.05
Leukemia_chronicMyelogenousK-56222.9
Leukemia_promyelocytic-HL-6019.9
Leukemialymphoblastic(MOLT-4)12.75
Liver70.6
Lung641.2
Lymphnode15.5
Lymphoma_burkitts(Daudi)94.5
Lymphoma_burkitts(Raji)26.65
MedullaOblongata9998.4
OccipitalLobe6879.75
OlfactoryBulb12
Ovary11.65
Pancreas11.8
PancreaticIslet15.65
ParietalLobe7982.05
Pituitary20.8
Placenta18.55
Pons6330.25
PrefrontalCortex14409.95
Prostate18.65
Salivarygland13.1
SkeletalMuscle19.5
Skin12.25
SmoothMuscle19.45
Spinalcord75.4
SubthalamicNucleus6728.45
SuperiorCervicalGanglion22
TemporalLobe8836.3
Testis22.35
TestisGermCell13.6
TestisIntersitial13.5
TestisLeydigCell17.5
TestisSeminiferousTubule15.4
Thalamus291.6
Thymus14.5
Thyroid27.4
Tongue14.7
Tonsil17.85
Trachea15.1
TrigeminalGanglion15.25
Uterus22.75
UterusCorpus15.9
WholeBlood2939.55
Wholebrain10078.45
colon18
pineal_day17.82
pineal_night14.78
retina21.65
small_intestine16
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P116264
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala13.1 ± 1.44
Basal Forebrain11.62 ± 0.79
Basal Part of Pons13.01 ± 0.61
Cerebellar Cortex9.2 ± 1.09
Cerebellar Nuclei8.31 ± 1.51
Claustrum11.68 ± 1.91
Epithalamus9.63 ± 1.09
Frontal Lobe11.96 ± 0.85
Globus Pallidus9.45 ± 3.12
Hypothalamus10.17 ± 1.29
Insula11.7 ± 0.88
Limbic Lobe12.11 ± 1.85
Mesencephalon10.58 ± 1.12
Myelencephalon11.04 ± 1.49
Occipital Lobe10.45 ± 1.19
Parietal Lobe11.8 ± 0.96
Pontine Tegmentum10.9 ± 1.24
Striatum12.29 ± 1.55
Subthalamus10.06 ± 0.69
Temporal Lobe11.84 ± 0.89
Thalamus9.75 ± 0.93
White Matter9.14 ± 2.63
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
NrgnCBCerebellum43.56
53.37
NrgnCTXCerebral cortex100
100
NrgnHIPHippocampal region100
100
NrgnHPFHippocampal formation100
100
NrgnHYHypothalamus44.56
51.82
NrgnLSXLateral septal complex69.96
71.17
NrgnMBMidbrain63.76
71.03
NrgnMYMedulla27.38
30.41
NrgnOLFOlfactory bulb95.52
100
NrgnPPons26.2
27.53
NrgnPALPallidum52.81
63.4
NrgnRHPRetrohippocampal region100
100
NrgnsAMYStriatum-like amygdalar nuclei85.77
94.61
NrgnSTRStriatum98.43
100
NrgnSTRdStriatum dorsal region100
100
NrgnSTRvStriatum ventral region73.37
74.35
NrgnTHThalamus47.77
50.52
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00136824 15 54 68 KGPGPGGPGGAGVAR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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