AutismKB 2.0

Annotation Detail for NRL


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Basic Information Top
Gene Symbol:NRL ( D14S46E,NRL-MAF,RP27 )
Gene Full Name: neural retina leucine zipper
Band: 14q11.2-q12
Quick LinksEntrez ID:4901; OMIM: 162080; Uniprot ID:NRL_HUMAN; ENSEMBL ID: ENSG00000129535; HGNC ID: 8002
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus4 / 5640127
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult44 / 193912122
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor5 / 26384518
glioma0 / 1068830 
head and neck tumor0 / 1363020 
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma2 / 7175527
non-neoplasia0 / 972500 
normal58 / 336030717
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS4 / 12568031
prostate cancer0 / 1026800 
retinoblastoma12 / 46356258
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood2 / 12347816
bone0 / 716550 
bone marrow0 / 488010 
brain7 / 11009896
cervix0 / 481710 
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue1 / 2157224
esophagus0 / 202090 
eye56 / 211054265
heart0 / 896260 
intestine0 / 2344720 
kidney0 / 2117770 
larynx0 / 241450 
liver3 / 20774314
lung0 / 3369740 
lymph0 / 442700 
lymph node0 / 916100 
mammary gland0 / 1532710 
mouth0 / 670520 
muscle0 / 1077150 
nerve0 / 157680 
ovary0 / 1020510 
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate0 / 1893450 
salivary gland0 / 201550 
skin0 / 2105740 
spleen0 / 539520 
stomach1 / 9661910
testis1 / 3304423
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus1 / 2328784
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 206597_at
Cell line Expression level Expression bar
721_B_lymphoblasts7.4
Adipocyte5.85
AdrenalCortex6.15
Adrenalgland5.1
Amygdala6.05
Appendix5.75
AtrioventricularNode6
BDCA4+_DentriticCells6.5
Bonemarrow5.8
BronchialEpithelialCells5.9
CD105+_Endothelial5.85
CD14+_Monocytes6
CD19+_BCells(neg._sel.)6.2
CD33+_Myeloid7.05
CD34+7.25
CD4+_Tcells6.35
CD56+_NKCells8.15
CD71+_EarlyErythroid8.7
CD8+_Tcells5.4
CardiacMyocytes8.6
Caudatenucleus5.45
Cerebellum4.75
CerebellumPeduncles6.7
CiliaryGanglion4.2
CingulateCortex6.65
Colorectaladenocarcinoma5.75
DorsalRootGanglion6
FetalThyroid5.75
Fetalbrain5.85
Fetalliver10.8
Fetallung4.9
GlobusPallidus4.25
Heart7.5
Hypothalamus6.15
Kidney4.75
Leukemia_chronicMyelogenousK-5625.25
Leukemia_promyelocytic-HL-605.1
Leukemialymphoblastic(MOLT-4)5.65
Liver8.95
Lung6.15
Lymphnode4.95
Lymphoma_burkitts(Daudi)7.5
Lymphoma_burkitts(Raji)8
MedullaOblongata5.15
OccipitalLobe6.15
OlfactoryBulb4.9
Ovary3.9
Pancreas4.65
PancreaticIslet6.25
ParietalLobe5.95
Pituitary10.7
Placenta6.2
Pons7.1
PrefrontalCortex7.1
Prostate6.85
Salivarygland6.35
SkeletalMuscle7.75
Skin6.8
SmoothMuscle10.2
Spinalcord6.3
SubthalamicNucleus5.65
SuperiorCervicalGanglion6.6
TemporalLobe5.3
Testis5.95
TestisGermCell4.75
TestisIntersitial5.3
TestisLeydigCell5.7
TestisSeminiferousTubule7.5
Thalamus5.85
Thymus4.6
Thyroid7.3
Tongue9.85
Tonsil5.7
Trachea5
TrigeminalGanglion5.95
Uterus4.5
UterusCorpus5.25
WholeBlood6.5
Wholebrain5.6
colon5.65
pineal_day7.64
pineal_night6.92
retina102.175
small_intestine5.7
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_12621_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.42 ± 1.02
Basal Forebrain1.96 ± 0.19
Basal Part of Pons1.7 ± 0.41
Cerebellar Cortex1.88 ± 0.76
Cerebellar Nuclei2.24 ± 0.73
Claustrum2.89 ± 0.89
Epithalamus1.73 ± 0.71
Frontal Lobe1.84 ± 0.65
Globus Pallidus2.51 ± 0.33
Hypothalamus2.11 ± 0.69
Insula2.01 ± 0.58
Limbic Lobe1.96 ± 0.59
Mesencephalon2.16 ± 0.72
Myelencephalon2.02 ± 0.65
Occipital Lobe2.01 ± 0.56
Parietal Lobe1.95 ± 0.7
Pontine Tegmentum2.05 ± 0.65
Striatum2.16 ± 0.49
Subthalamus2.16 ± 0.47
Temporal Lobe1.95 ± 0.67
Thalamus1.98 ± 0.58
White Matter2.35 ± 0.13
Mouse Brain ISH
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018