AutismKB 2.0

Annotation Detail for NTRK2


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Basic Information Top
Gene Symbol:NTRK2 ( GP145-TrkB,TRKB )
Gene Full Name: neurotrophic tyrosine kinase, receptor, type 2
Band: 9q21.33
Quick LinksEntrez ID:4915; OMIM: 600456; Uniprot ID:NTRK2_HUMAN; ENSEMBL ID: ENSG00000148053; HGNC ID: 8032
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body3 / 7076142
blastocyst0 / 623190 
fetus45 / 56401279
neonate0 / 310970 
infant3 / 23620127
juvenile1 / 5555617
adult181 / 193912193
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma1 / 1747557
breast (mammary gland) tumor1 / 9417810
cervical tumor0 / 343660 
chondrosarcoma6 / 8282372
colorectal tumor3 / 11424626
esophageal tumor9 / 17290520
gastrointestinal tumor1 / 1193698
germ cell tumor61 / 263845231
glioma31 / 106883290
head and neck tumor84 / 136302616
kidney tumor14 / 68959203
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor5 / 10312748
lymphoma0 / 717550 
non-neoplasia24 / 97250246
normal394 / 3360307117
ovarian tumor4 / 7668252
pancreatic tumor2 / 10461619
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland1 / 3319730
ascites0 / 400150 
bladder1 / 2975733
blood0 / 1234780 
bone6 / 7165583
bone marrow0 / 488010 
brain325 / 1100989295
cervix0 / 481710 
connective tissue14 / 14925593
ear4 / 16212246
embryonic tissue5 / 21572223
esophagus9 / 20209445
eye23 / 211054108
heart13 / 89626145
intestine9 / 23447238
kidney16 / 21177775
larynx0 / 241450 
liver2 / 2077439
lung8 / 33697423
lymph0 / 442700 
lymph node0 / 916100 
mammary gland6 / 15327139
mouth80 / 670521193
muscle5 / 10771546
nerve1 / 1576863
ovary1 / 1020519
pancreas6 / 21481227
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland1 / 1658560
placenta0 / 2808250 
prostate3 / 18934515
salivary gland0 / 201550 
skin0 / 2105740 
spleen3 / 5395255
stomach2 / 9661920
testis42 / 330442127
thymus2 / 8113124
thyroid10 / 47473210
tonsil0 / 169990 
trachea9 / 52413171
umbilical cord0 / 136800 
uterus3 / 23287812
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 207152_at
Cell line Expression level Expression bar
721_B_lymphoblasts5.65
Adipocyte4.75
AdrenalCortex5.25
Adrenalgland4.25
Amygdala6.3
Appendix6.15
AtrioventricularNode4.05
BDCA4+_DentriticCells5
Bonemarrow5.6
BronchialEpithelialCells4.75
CD105+_Endothelial4.85
CD14+_Monocytes5.15
CD19+_BCells(neg._sel.)5.05
CD33+_Myeloid5.95
CD34+6.6
CD4+_Tcells5.8
CD56+_NKCells5.55
CD71+_EarlyErythroid4.5
CD8+_Tcells4.55
CardiacMyocytes7
Caudatenucleus4.4
Cerebellum6.45
CerebellumPeduncles5.65
CiliaryGanglion3.7
CingulateCortex5.3
Colorectaladenocarcinoma4.95
DorsalRootGanglion4.1
FetalThyroid4.9
Fetalbrain4.85
Fetalliver4.3
Fetallung4
GlobusPallidus3.85
Heart6.35
Hypothalamus5.05
Kidney4.25
Leukemia_chronicMyelogenousK-5624.45
Leukemia_promyelocytic-HL-604.3
Leukemialymphoblastic(MOLT-4)4.6
Liver6.85
Lung5.15
Lymphnode4.15
Lymphoma_burkitts(Daudi)6.45
Lymphoma_burkitts(Raji)7.2
MedullaOblongata4.95
OccipitalLobe5.05
OlfactoryBulb4.05
Ovary5.15
Pancreas4.05
PancreaticIslet5.3
ParietalLobe5.4
Pituitary6.5
Placenta5
Pons5.75
PrefrontalCortex5.95
Prostate5.75
Salivarygland4.25
SkeletalMuscle6.3
Skin4.9
SmoothMuscle5.5
Spinalcord5.25
SubthalamicNucleus4.6
SuperiorCervicalGanglion6.65
TemporalLobe4.65
Testis4.2
TestisGermCell4
TestisIntersitial4.15
TestisLeydigCell5.1
TestisSeminiferousTubule5.95
Thalamus5.05
Thymus3.85
Thyroid6.05
Tongue5.05
Tonsil4.8
Trachea4.1
TrigeminalGanglion4.95
Uterus4
UterusCorpus4.4
WholeBlood5.35
Wholebrain11.45
colon5
pineal_day5.96
pineal_night5.78
retina6
small_intestine4.75
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_486_PI416408490
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala11.7 ± 0.36
Basal Forebrain11.7 ± 0.23
Basal Part of Pons10.33 ± 0.35
Cerebellar Cortex10.62 ± 0.26
Cerebellar Nuclei10.46 ± 0.54
Claustrum11.21 ± 0.39
Epithalamus11.92 ± 0.15
Frontal Lobe11.11 ± 0.47
Globus Pallidus12.62 ± 0.43
Hypothalamus11.61 ± 0.2
Insula11.31 ± 0.37
Limbic Lobe11.14 ± 0.61
Mesencephalon11.48 ± 0.53
Myelencephalon11.34 ± 0.6
Occipital Lobe11.19 ± 0.37
Parietal Lobe11.22 ± 0.53
Pontine Tegmentum11.39 ± 0.37
Striatum11.89 ± 0.44
Subthalamus10.61 ± 0.3
Temporal Lobe11.22 ± 0.38
Thalamus11.61 ± 0.39
White Matter10.45 ± 0.18
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Ntrk2CBCerebellum68.39
71.91
Ntrk2CTXCerebral cortex100
100
Ntrk2HIPHippocampal region93.22
89.87
Ntrk2HPFHippocampal formation98.52
92.47
Ntrk2HYHypothalamus87.72
77.43
Ntrk2LSXLateral septal complex100
100
Ntrk2MBMidbrain71.12
65.29
Ntrk2MYMedulla67.54
65.3
Ntrk2OLFOlfactory bulb100
100
Ntrk2PPons70.8
64.63
Ntrk2PALPallidum82.26
73.37
Ntrk2RHPRetrohippocampal region100
94.01
Ntrk2sAMYStriatum-like amygdalar nuclei100
97.15
Ntrk2STRStriatum89.88
78.89
Ntrk2STRdStriatum dorsal region80.81
71.78
Ntrk2STRvStriatum ventral region87.57
73.78
Ntrk2THThalamus81.35
68.63
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00618362 16 167 182 SSPDTQDLYCLNESSK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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