AutismKB 2.0

Annotation Detail for NTRK3


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Basic Information Top
Gene Symbol:NTRK3 ( TRKC,gp145(trkC) )
Gene Full Name: neurotrophic tyrosine kinase, receptor, type 3
Band: 15q25.3
Quick LinksEntrez ID:4916; OMIM: 191316; Uniprot ID:NTRK3_HUMAN; ENSEMBL ID: ENSG00000140538; HGNC ID: 8033
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst0 / 623190 
fetus17 / 56401230
neonate0 / 310970 
infant1 / 2362042
juvenile0 / 555560 
adult34 / 193912117
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor1 / 1193698
germ cell tumor6 / 26384522
glioma4 / 10688337
head and neck tumor2 / 13630214
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal74 / 336030722
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor5 / 12519139
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain51 / 110098946
cervix0 / 481710 
connective tissue3 / 14925520
ear0 / 162120 
embryonic tissue1 / 2157224
esophagus0 / 202090 
eye6 / 21105428
heart0 / 896260 
intestine1 / 2344724
kidney3 / 21177714
larynx2 / 2414582
liver0 / 2077430 
lung1 / 3369742
lymph0 / 442700 
lymph node0 / 916100 
mammary gland0 / 1532710 
mouth0 / 670520 
muscle1 / 1077159
nerve0 / 157680 
ovary1 / 1020519
pancreas2 / 2148129
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland1 / 1658560
placenta0 / 2808250 
prostate2 / 18934510
salivary gland0 / 201550 
skin1 / 2105744
spleen0 / 539520 
stomach1 / 9661910
testis15 / 33044245
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus0 / 2328780 
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 206462_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts6.8
Adipocyte5.9
AdrenalCortex6.75
Adrenalgland5.3
Amygdala6.55
Appendix6.5
AtrioventricularNode4.95
BDCA4+_DentriticCells6.1
Bonemarrow6.7
BronchialEpithelialCells5.8
CD105+_Endothelial6.3
CD14+_Monocytes6.35
CD19+_BCells(neg._sel.)6.4
CD33+_Myeloid7.55
CD34+7.2
CD4+_Tcells6.45
CD56+_NKCells7.1
CD71+_EarlyErythroid5.8
CD8+_Tcells5.65
CardiacMyocytes7.85
Caudatenucleus5.5
Cerebellum5.05
CerebellumPeduncles17.75
CiliaryGanglion6.45
CingulateCortex45.1
Colorectaladenocarcinoma6.15
DorsalRootGanglion6.75
FetalThyroid5.95
Fetalbrain5.9
Fetalliver5.5
Fetallung4.65
GlobusPallidus17.45
Heart7.9
Hypothalamus6.7
Kidney5.35
Leukemia_chronicMyelogenousK-5625.6
Leukemia_promyelocytic-HL-605.4
Leukemialymphoblastic(MOLT-4)4.95
Liver8.25
Lung6.55
Lymphnode5.15
Lymphoma_burkitts(Daudi)8.1
Lymphoma_burkitts(Raji)8.85
MedullaOblongata34.2
OccipitalLobe19.7
OlfactoryBulb24.3
Ovary4.45
Pancreas5.1
PancreaticIslet6.5
ParietalLobe16.9
Pituitary7.05
Placenta6.1
Pons16.3
PrefrontalCortex21.45
Prostate7
Salivarygland5
SkeletalMuscle11.5
Skin5.3
SmoothMuscle6.85
Spinalcord6.6
SubthalamicNucleus26.1
SuperiorCervicalGanglion8.35
TemporalLobe22.65
Testis5.25
TestisGermCell4.8
TestisIntersitial5.2
TestisLeydigCell6.65
TestisSeminiferousTubule5.3
Thalamus6.3
Thymus4.55
Thyroid7.3
Tongue6.15
Tonsil6.25
Trachea5.1
TrigeminalGanglion7.55
Uterus4.8
UterusCorpus5.65
WholeBlood6.6
Wholebrain5.35
colon6.1
pineal_day7.72
pineal_night7.64
retina13.575
small_intestine5.8
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_487_PI416408490
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.22 ± 0.43
Basal Forebrain6.33 ± 0.39
Basal Part of Pons6.13 ± 0.24
Cerebellar Cortex5.85 ± 0.36
Cerebellar Nuclei5.67 ± 0.35
Claustrum6.16 ± 0.48
Epithalamus5.56 ± 0.33
Frontal Lobe5.76 ± 0.41
Globus Pallidus5.74 ± 0.37
Hypothalamus5.79 ± 0.54
Insula5.89 ± 0.51
Limbic Lobe6.18 ± 0.47
Mesencephalon5.84 ± 0.56
Myelencephalon5.96 ± 0.5
Occipital Lobe6.24 ± 0.49
Parietal Lobe5.93 ± 0.45
Pontine Tegmentum5.81 ± 0.41
Striatum6.64 ± 0.43
Subthalamus6.05 ± 0.82
Temporal Lobe5.95 ± 0.38
Thalamus5.58 ± 0.47
White Matter4.5 ± 0.25
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Ntrk3CBCerebellum1.58
1.98
Ntrk3CTXCerebral cortex7.56
2.74
Ntrk3HIPHippocampal region15.25
10.7
Ntrk3HPFHippocampal formation11.7
6.67
Ntrk3HYHypothalamus0.64
0.47
Ntrk3LSXLateral septal complex0.94
0.76
Ntrk3MBMidbrain4.64
5.34
Ntrk3MYMedulla2.61
1.48
Ntrk3OLFOlfactory bulb7.33
3.93
Ntrk3PPons1.69
1.18
Ntrk3PALPallidum2.12
2.39
Ntrk3RHPRetrohippocampal region7.9
2.86
Ntrk3sAMYStriatum-like amygdalar nuclei0.13
0.1
Ntrk3STRStriatum0.81
0.56
Ntrk3STRdStriatum dorsal region0.62
0.24
Ntrk3STRvStriatum ventral region1.76
1.74
Ntrk3THThalamus1.12
0.78
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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