AutismKB 2.0

Annotation Detail for DDR2


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Basic Information Top
Gene Symbol:DDR2 ( MIG20a,NTRKR3,TKT,TYRO10 )
Gene Full Name: discoidin domain receptor tyrosine kinase 2
Band: 1q23.3
Quick LinksEntrez ID:4921; OMIM: 191311; Uniprot ID:DDR2_HUMAN; ENSEMBL ID: ENSG00000162733; HGNC ID: 2731
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body4 / 7076156
blastocyst2 / 6231932
fetus57 / 564012101
neonate2 / 3109764
infant0 / 236200 
juvenile1 / 5555617
adult91 / 193912146
embryoid body3 / 7076142
blastocyst0 / 623190 
fetus21 / 56401237
neonate1 / 3109732
infant0 / 236200 
juvenile4 / 5555671
adult51 / 193912126
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor3 / 9417831
cervical tumor0 / 343660 
chondrosarcoma16 / 82823193
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor13 / 119369108
germ cell tumor10 / 26384537
glioma4 / 10688337
head and neck tumor3 / 13630222
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor1 / 9635910
lung tumor1 / 1031279
lymphoma1 / 7175513
non-neoplasia5 / 9725051
normal186 / 336030755
ovarian tumor4 / 7668252
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS3 / 12568023
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor2 / 12519115
uterine tumor4 / 9025744
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma4 / 8282348
colorectal tumor1 / 1142468
esophageal tumor0 / 172900 
gastrointestinal tumor7 / 11936958
germ cell tumor6 / 26384522
glioma1 / 1068839
head and neck tumor1 / 1363027
kidney tumor2 / 6895929
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia1 / 9725010
normal101 / 336030730
ovarian tumor4 / 7668252
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS5 / 12568039
prostate cancer2 / 10268019
retinoblastoma0 / 463560 
skin tumor5 / 12494940
soft tissue/muscle tissue tumor2 / 12519115
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland2 / 3319760
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone15 / 71655209
bone marrow1 / 4880120
brain24 / 110098921
cervix0 / 481710 
connective tissue19 / 149255127
ear9 / 16212555
embryonic tissue9 / 21572241
esophagus0 / 202090 
eye10 / 21105447
heart21 / 89626234
intestine2 / 2344728
kidney11 / 21177751
larynx1 / 2414541
liver1 / 2077434
lung10 / 33697429
lymph0 / 442700 
lymph node1 / 9161010
mammary gland4 / 15327126
mouth0 / 670520 
muscle3 / 10771527
nerve2 / 15768126
ovary4 / 10205139
pancreas1 / 2148124
parathyroid1 / 2053948
pharynx0 / 413280 
pituitary gland1 / 1658560
placenta3 / 28082510
prostate4 / 18934521
salivary gland0 / 201550 
skin24 / 210574113
spleen0 / 539520 
stomach12 / 96619124
testis3 / 3304429
thymus0 / 811310 
thyroid2 / 4747342
tonsil0 / 169990 
trachea10 / 52413190
umbilical cord2 / 13680146
uterus22 / 23287894
vascular3 / 5178057
adipose tissue3 / 13106228
adrenal gland6 / 33197180
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone3 / 7165541
bone marrow2 / 4880140
brain15 / 110098913
cervix0 / 481710 
connective tissue5 / 14925533
ear0 / 162120 
embryonic tissue4 / 21572218
esophagus0 / 202090 
eye4 / 21105418
heart4 / 8962644
intestine4 / 23447217
kidney6 / 21177728
larynx0 / 241450 
liver2 / 2077439
lung7 / 33697420
lymph0 / 442700 
lymph node3 / 9161032
mammary gland0 / 1532710 
mouth1 / 6705214
muscle10 / 10771592
nerve0 / 157680 
ovary4 / 10205139
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland1 / 1658560
placenta5 / 28082517
prostate3 / 18934515
salivary gland0 / 201550 
skin12 / 21057456
spleen0 / 539520 
stomach8 / 9661982
testis8 / 33044224
thymus1 / 8113112
thyroid0 / 474730 
tonsil0 / 169990 
trachea8 / 52413152
umbilical cord4 / 13680292
uterus7 / 23287830
vascular8 / 51780154
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 205168_at
Cell line Expression level Expression bar
721_B_lymphoblasts9.95
Adipocyte77.95
AdrenalCortex43
Adrenalgland51.6
Amygdala7.55
Appendix9.7
AtrioventricularNode9.65
BDCA4+_DentriticCells7.2
Bonemarrow8.65
BronchialEpithelialCells7.1
CD105+_Endothelial8.15
CD14+_Monocytes6.45
CD19+_BCells(neg._sel.)6.6
CD33+_Myeloid9.1
CD34+9.4
CD4+_Tcells7.4
CD56+_NKCells6.75
CD71+_EarlyErythroid7
CD8+_Tcells5.05
CardiacMyocytes15.35
Caudatenucleus6.95
Cerebellum6.5
CerebellumPeduncles9.2
CiliaryGanglion12.1
CingulateCortex8.25
Colorectaladenocarcinoma7.45
DorsalRootGanglion6.85
FetalThyroid7.85
Fetalbrain7.6
Fetalliver7.05
Fetallung6.6
GlobusPallidus6.3
Heart10
Hypothalamus8.7
Kidney7.1
Leukemia_chronicMyelogenousK-5627
Leukemia_promyelocytic-HL-606.95
Leukemialymphoblastic(MOLT-4)5.95
Liver8.9
Lung8.85
Lymphnode6.85
Lymphoma_burkitts(Daudi)10.45
Lymphoma_burkitts(Raji)11.15
MedullaOblongata7.25
OccipitalLobe7.05
OlfactoryBulb25.85
Ovary8.65
Pancreas6.3
PancreaticIslet8.35
ParietalLobe10.75
Pituitary13.8
Placenta7.35
Pons7.7
PrefrontalCortex9.9
Prostate9.65
Salivarygland6.55
SkeletalMuscle9.4
Skin7.25
SmoothMuscle54.4
Spinalcord8.6
SubthalamicNucleus7.55
SuperiorCervicalGanglion13.3
TemporalLobe7.35
Testis6.6
TestisGermCell6.55
TestisIntersitial6.8
TestisLeydigCell8
TestisSeminiferousTubule6.85
Thalamus7.95
Thymus6.35
Thyroid9
Tongue9.05
Tonsil8.5
Trachea12.15
TrigeminalGanglion15.75
Uterus19.65
UterusCorpus19.85
WholeBlood8.2
Wholebrain5.35
colon8.35
pineal_day21.42
pineal_night9.94
retina21.65
small_intestine7.8
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_11314_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.25 ± 0.55
Basal Forebrain4.35 ± 0.5
Basal Part of Pons4.21 ± 0.53
Cerebellar Cortex4.24 ± 0.49
Cerebellar Nuclei3.84 ± 0.4
Claustrum4.01 ± 0.61
Epithalamus5.69 ± 0.23
Frontal Lobe4.2 ± 0.6
Globus Pallidus5.54 ± 0.5
Hypothalamus4.48 ± 0.58
Insula4.09 ± 0.62
Limbic Lobe4.18 ± 0.69
Mesencephalon4.52 ± 0.56
Myelencephalon4.46 ± 0.59
Occipital Lobe4.4 ± 0.48
Parietal Lobe4.36 ± 0.56
Pontine Tegmentum3.95 ± 0.46
Striatum4.17 ± 0.71
Subthalamus3.88 ± 0.44
Temporal Lobe4.11 ± 0.51
Thalamus4.75 ± 0.46
White Matter4.55 ± 0.5
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Ddr2CBCerebellum1.02
1.62
Ddr2CTXCerebral cortex1.69
2.63
Ddr2HIPHippocampal region1.19
1.4
Ddr2HPFHippocampal formation1.23
1.27
Ddr2HYHypothalamus0.19
0.18
Ddr2LSXLateral septal complex2.96
2.08
Ddr2MBMidbrain0.69
1.41
Ddr2MYMedulla0.78
1.47
Ddr2OLFOlfactory bulb2.16
3.31
Ddr2PPons0.58
0.69
Ddr2PALPallidum0.27
0.29
Ddr2RHPRetrohippocampal region1.09
0.81
Ddr2sAMYStriatum-like amygdalar nuclei0.62
0.58
Ddr2STRStriatum2.81
3.29
Ddr2STRdStriatum dorsal region4.02
5.12
Ddr2STRvStriatum ventral region0.81
0.77
Ddr2THThalamus0.76
1.08
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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