AutismKB 2.0

Annotation Detail for NR4A2


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Basic Information Top
Gene Symbol:NR4A2 ( HZF-3,NOT,NURR1,RNR1,TINUR )
Gene Full Name: nuclear receptor subfamily 4, group A, member 2
Band: 2q22-q23
Quick LinksEntrez ID:4929; OMIM: 601828; Uniprot ID:NR4A2_HUMAN; ENSEMBL ID: ENSG00000153234; HGNC ID: 7981
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus93 / 564012164
neonate1 / 3109732
infant0 / 236200 
juvenile3 / 5555653
adult58 / 193912129
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor1 / 9417810
cervical tumor0 / 343660 
chondrosarcoma3 / 8282336
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor5 / 11936941
germ cell tumor3 / 26384511
glioma0 / 1068830 
head and neck tumor15 / 136302110
kidney tumor2 / 6895929
leukemia1 / 9584210
liver tumor3 / 9635931
lung tumor1 / 1031279
lymphoma0 / 717550 
non-neoplasia2 / 9725020
normal237 / 336030770
ovarian tumor5 / 7668265
pancreatic tumor2 / 10461619
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer5 / 10268048
retinoblastoma0 / 463560 
skin tumor1 / 1249498
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland6 / 33197180
ascites0 / 400150 
bladder1 / 2975733
blood16 / 123478129
bone0 / 716550 
bone marrow5 / 48801102
brain149 / 1100989135
cervix1 / 4817120
connective tissue4 / 14925526
ear1 / 1621261
embryonic tissue1 / 2157224
esophagus0 / 202090 
eye8 / 21105437
heart1 / 8962611
intestine2 / 2344728
kidney5 / 21177723
larynx0 / 241450 
liver9 / 20774343
lung23 / 33697468
lymph0 / 442700 
lymph node0 / 916100 
mammary gland2 / 15327113
mouth14 / 67052208
muscle1 / 1077159
nerve4 / 15768253
ovary5 / 10205148
pancreas3 / 21481213
parathyroid1 / 2053948
pharynx0 / 413280 
pituitary gland1 / 1658560
placenta0 / 2808250 
prostate7 / 18934536
salivary gland0 / 201550 
skin2 / 2105749
spleen1 / 5395218
stomach5 / 9661951
testis8 / 33044224
thymus2 / 8113124
thyroid6 / 47473126
tonsil0 / 169990 
trachea23 / 52413438
umbilical cord0 / 136800 
uterus4 / 23287817
vascular2 / 5178038
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 204622_x_at
Cell line Expression level Expression bar
721_B_lymphoblasts8.35
Adipocyte7.85
AdrenalCortex583.45
Adrenalgland106
Amygdala45.8
Appendix49.45
AtrioventricularNode12.55
BDCA4+_DentriticCells93.45
Bonemarrow9.05
BronchialEpithelialCells8.45
CD105+_Endothelial10.2
CD14+_Monocytes14.25
CD19+_BCells(neg._sel.)10.2
CD33+_Myeloid753.9
CD34+25.35
CD4+_Tcells12
CD56+_NKCells31.35
CD71+_EarlyErythroid8.95
CD8+_Tcells12.45
CardiacMyocytes11.05
Caudatenucleus7.95
Cerebellum103.35
CerebellumPeduncles19.45
CiliaryGanglion8.65
CingulateCortex9.8
Colorectaladenocarcinoma8.15
DorsalRootGanglion14.25
FetalThyroid9.25
Fetalbrain34.05
Fetalliver8.65
Fetallung12.35
GlobusPallidus8.05
Heart11.15
Hypothalamus10.65
Kidney9.2
Leukemia_chronicMyelogenousK-5628.25
Leukemia_promyelocytic-HL-606.65
Leukemialymphoblastic(MOLT-4)6.15
Liver12
Lung11.85
Lymphnode9.3
Lymphoma_burkitts(Daudi)11.05
Lymphoma_burkitts(Raji)13.15
MedullaOblongata9.1
OccipitalLobe8.9
OlfactoryBulb52.75
Ovary71.5
Pancreas6.75
PancreaticIslet14
ParietalLobe10.95
Pituitary16.45
Placenta7.25
Pons9.7
PrefrontalCortex11.45
Prostate31.75
Salivarygland33
SkeletalMuscle12.45
Skin7.75
SmoothMuscle8.6
Spinalcord41
SubthalamicNucleus9.4
SuperiorCervicalGanglion51.45
TemporalLobe8.85
Testis6.6
TestisGermCell7.1
TestisIntersitial6.85
TestisLeydigCell9.05
TestisSeminiferousTubule7.65
Thalamus9.3
Thymus7.05
Thyroid13.05
Tongue8.95
Tonsil7.8
Trachea80.4
TrigeminalGanglion10.65
Uterus8.25
UterusCorpus9.3
WholeBlood10.8
Wholebrain27.6
colon10
pineal_day100.28
pineal_night30.96
retina12.225
small_intestine9.55
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_482_PI416408490
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.65 ± 0.91
Basal Forebrain3.04 ± 0.4
Basal Part of Pons3.21 ± 0.77
Cerebellar Cortex3.62 ± 0.79
Cerebellar Nuclei3.19 ± 0.41
Claustrum5.54 ± 0.4
Epithalamus3.42 ± 0.67
Frontal Lobe3.38 ± 0.82
Globus Pallidus3.05 ± 1.03
Hypothalamus3.02 ± 0.71
Insula3.84 ± 0.54
Limbic Lobe3.75 ± 0.76
Mesencephalon3.74 ± 1.07
Myelencephalon3.48 ± 0.81
Occipital Lobe3.38 ± 0.93
Parietal Lobe3.34 ± 0.79
Pontine Tegmentum3.38 ± 0.67
Striatum2.97 ± 0.81
Subthalamus3.9 ± 0.24
Temporal Lobe3.56 ± 0.72
Thalamus3.1 ± 0.69
White Matter4.09 ± 0.73
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Nr4a2CBCerebellum100
91.64
Nr4a2CTXCerebral cortex97.31
79.16
Nr4a2HIPHippocampal region85.59
86.87
Nr4a2HPFHippocampal formation99.82
100
Nr4a2HYHypothalamus86.69
74.05
Nr4a2LSXLateral septal complex95.96
46.72
Nr4a2MBMidbrain83.48
66.58
Nr4a2MYMedulla81.7
80.5
Nr4a2OLFOlfactory bulb100
100
Nr4a2PPons76.79
74.27
Nr4a2PALPallidum88.4
67.11
Nr4a2RHPRetrohippocampal region100
100
Nr4a2sAMYStriatum-like amygdalar nuclei100
68.27
Nr4a2STRStriatum88.08
59.36
Nr4a2STRdStriatum dorsal region78.83
51.26
Nr4a2STRvStriatum ventral region100
79.16
Nr4a2THThalamus81.71
71.1
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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