AutismKB 2.0

Annotation Detail for OAS1


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Basic Information Top
Gene Symbol:OAS1 ( IFI-4,OIAS,OIASI )
Gene Full Name: 2',5'-oligoadenylate synthetase 1, 40/46kDa
Band: 12q24.2
Quick LinksEntrez ID:4938; OMIM: 164350; Uniprot ID:OAS1_HUMAN; ENSEMBL ID: ENSG00000089127; HGNC ID: 8086
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus16 / 56401228
neonate1 / 3109732
infant0 / 236200 
juvenile2 / 5555635
adult151 / 193912177
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma1 / 1747557
breast (mammary gland) tumor22 / 94178233
cervical tumor4 / 34366116
chondrosarcoma4 / 8282348
colorectal tumor25 / 114246218
esophageal tumor0 / 172900 
gastrointestinal tumor8 / 11936967
germ cell tumor18 / 26384568
glioma8 / 10688374
head and neck tumor5 / 13630236
kidney tumor1 / 6895914
leukemia2 / 9584220
liver tumor9 / 9635993
lung tumor7 / 10312767
lymphoma11 / 71755153
non-neoplasia8 / 9725082
normal121 / 336030736
ovarian tumor0 / 766820 
pancreatic tumor2 / 10461619
primitive neuroectodermal tumor of the CNS4 / 12568031
prostate cancer1 / 1026809
retinoblastoma0 / 463560 
skin tumor13 / 124949104
soft tissue/muscle tissue tumor14 / 125191111
uterine tumor4 / 9025744
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue2 / 13106152
adrenal gland1 / 3319730
ascites6 / 40015149
bladder4 / 29757134
blood8 / 12347864
bone4 / 7165555
bone marrow1 / 4880120
brain35 / 110098931
cervix8 / 48171166
connective tissue7 / 14925546
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus1 / 2020949
eye2 / 2110549
heart2 / 8962622
intestine44 / 234472187
kidney6 / 21177728
larynx1 / 2414541
liver10 / 20774348
lung26 / 33697477
lymph4 / 4427090
lymph node5 / 9161054
mammary gland23 / 153271150
mouth3 / 6705244
muscle2 / 10771518
nerve0 / 157680 
ovary1 / 1020519
pancreas5 / 21481223
parathyroid0 / 205390 
pharynx2 / 4132848
pituitary gland0 / 165850 
placenta9 / 28082532
prostate4 / 18934521
salivary gland0 / 201550 
skin15 / 21057471
spleen2 / 5395237
stomach5 / 9661951
testis6 / 33044218
thymus4 / 8113149
thyroid2 / 4747342
tonsil4 / 16999235
trachea3 / 5241357
umbilical cord0 / 136800 
uterus21 / 23287890
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 205552_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts189.35
Adipocyte7.55
AdrenalCortex8.5
Adrenalgland6.6
Amygdala7.3
Appendix7.9
AtrioventricularNode6.4
BDCA4+_DentriticCells89.35
Bonemarrow7.95
BronchialEpithelialCells6.85
CD105+_Endothelial7.4
CD14+_Monocytes229.2
CD19+_BCells(neg._sel.)9.5
CD33+_Myeloid44.65
CD34+8.4
CD4+_Tcells9.05
CD56+_NKCells34.4
CD71+_EarlyErythroid7.05
CD8+_Tcells6.65
CardiacMyocytes12.35
Caudatenucleus6.65
Cerebellum6.1
CerebellumPeduncles8.75
CiliaryGanglion9.85
CingulateCortex7.55
Colorectaladenocarcinoma7.35
DorsalRootGanglion6.4
FetalThyroid7.35
Fetalbrain7.05
Fetalliver6.5
Fetallung5.5
GlobusPallidus5.85
Heart12.2
Hypothalamus7.9
Kidney6.65
Leukemia_chronicMyelogenousK-5626.4
Leukemia_promyelocytic-HL-606.45
Leukemialymphoblastic(MOLT-4)5.7
Liver10.95
Lung9.55
Lymphnode7.9
Lymphoma_burkitts(Daudi)87.75
Lymphoma_burkitts(Raji)11.2
MedullaOblongata6.65
OccipitalLobe6.5
OlfactoryBulb5.8
Ovary5.1
Pancreas65.55
PancreaticIslet7.75
ParietalLobe8.15
Pituitary8.65
Placenta7.75
Pons7.85
PrefrontalCortex9.3
Prostate8.3
Salivarygland6.25
SkeletalMuscle15.3
Skin6.5
SmoothMuscle7.95
Spinalcord7.75
SubthalamicNucleus6.95
SuperiorCervicalGanglion10.75
TemporalLobe6.9
Testis6.25
TestisGermCell6.05
TestisIntersitial6.35
TestisLeydigCell7.6
TestisSeminiferousTubule6.35
Thalamus7.65
Thymus6.1
Thyroid8.7
Tongue7.9
Tonsil11.85
Trachea7.45
TrigeminalGanglion8.75
Uterus5.95
UterusCorpus7.2
WholeBlood28.3
Wholebrain6.15
colon23.8
pineal_day8.96
pineal_night8.84
retina9.25
small_intestine26.7
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_12964_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.21 ± 1.32
Basal Forebrain6.05 ± 0.79
Basal Part of Pons5.13 ± 1.57
Cerebellar Cortex4.47 ± 0.59
Cerebellar Nuclei5.1 ± 1.13
Claustrum7.05 ± 1.24
Epithalamus4.9 ± 1.13
Frontal Lobe4.78 ± 1.16
Globus Pallidus7.63 ± 0.83
Hypothalamus4.69 ± 0.84
Insula5.01 ± 1.31
Limbic Lobe5.9 ± 1.56
Mesencephalon5.76 ± 1.13
Myelencephalon5.61 ± 1.39
Occipital Lobe6.16 ± 1.21
Parietal Lobe5.61 ± 1.36
Pontine Tegmentum5.35 ± 1.32
Striatum6.36 ± 1.52
Subthalamus6.1 ± 1.03
Temporal Lobe5.36 ± 1.32
Thalamus5.2 ± 0.96
White Matter6.97 ± 1.23
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Oas1gCBCerebellum1.96
2.68
Oas1gCTXCerebral cortex4.09
3.42
Oas1gHIPHippocampal region2.62
2.56
Oas1gHPFHippocampal formation2.19
2.17
Oas1gHYHypothalamus3.22
4.98
Oas1gLSXLateral septal complex0.58
0.53
Oas1gMBMidbrain1.4
1.95
Oas1gMYMedulla17.99
23.6
Oas1gOLFOlfactory bulb8.22
7.04
Oas1gPPons7.81
9.72
Oas1gPALPallidum3.16
2.7
Oas1gRHPRetrohippocampal region0.99
1.3
Oas1gsAMYStriatum-like amygdalar nuclei5.17
4.06
Oas1gSTRStriatum7.28
5.45
Oas1gSTRdStriatum dorsal region8.01
5.86
Oas1gSTRvStriatum ventral region10.5
7.92
Oas1gTHThalamus0.97
0.79
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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