AutismKB 2.0

Annotation Detail for OAS3


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Basic Information Top
Gene Symbol:OAS3 ( MGC133260,p100 )
Gene Full Name: 2'-5'-oligoadenylate synthetase 3, 100kDa
Band: 12q24.13
Quick LinksEntrez ID:4940; OMIM: 603351; Uniprot ID:OAS3_HUMAN; ENSEMBL ID: ENSG00000111331; HGNC ID: 8088
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus9 / 56401215
neonate0 / 310970 
infant0 / 236200 
juvenile3 / 5555653
adult134 / 193912169
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma1 / 1747557
breast (mammary gland) tumor29 / 94178307
cervical tumor1 / 3436629
chondrosarcoma3 / 8282336
colorectal tumor11 / 11424696
esophageal tumor2 / 17290115
gastrointestinal tumor9 / 11936975
germ cell tumor6 / 26384522
glioma5 / 10688346
head and neck tumor14 / 136302102
kidney tumor4 / 6895958
leukemia5 / 9584252
liver tumor4 / 9635941
lung tumor3 / 10312729
lymphoma2 / 7175527
non-neoplasia1 / 9725010
normal88 / 336030726
ovarian tumor1 / 7668213
pancreatic tumor4 / 10461638
primitive neuroectodermal tumor of the CNS6 / 12568047
prostate cancer3 / 10268029
retinoblastoma0 / 463560 
skin tumor33 / 124949264
soft tissue/muscle tissue tumor39 / 125191311
uterine tumor15 / 90257166
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue2 / 13106152
adrenal gland0 / 331970 
ascites1 / 4001524
bladder4 / 29757134
blood3 / 12347824
bone2 / 7165527
bone marrow0 / 488010 
brain25 / 110098922
cervix1 / 4817120
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus2 / 2020998
eye8 / 21105437
heart4 / 8962644
intestine13 / 23447255
kidney5 / 21177723
larynx0 / 241450 
liver5 / 20774324
lung26 / 33697477
lymph0 / 442700 
lymph node7 / 9161076
mammary gland31 / 153271202
mouth12 / 67052178
muscle6 / 10771555
nerve1 / 1576863
ovary1 / 1020519
pancreas9 / 21481241
parathyroid0 / 205390 
pharynx3 / 4132872
pituitary gland0 / 165850 
placenta7 / 28082524
prostate5 / 18934526
salivary gland0 / 201550 
skin38 / 210574180
spleen1 / 5395218
stomach7 / 9661972
testis4 / 33044212
thymus6 / 8113173
thyroid0 / 474730 
tonsil0 / 169990 
trachea4 / 5241376
umbilical cord0 / 136800 
uterus60 / 232878257
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 218400_at
Cell line Expression level Expression bar
721_B_lymphoblasts14.95
Adipocyte8
AdrenalCortex10.2
Adrenalgland9.8
Amygdala8.25
Appendix9.9
AtrioventricularNode7.5
BDCA4+_DentriticCells10.95
Bonemarrow8.3
BronchialEpithelialCells8.15
CD105+_Endothelial7
CD14+_Monocytes41.55
CD19+_BCells(neg._sel.)7.25
CD33+_Myeloid91.95
CD34+8.45
CD4+_Tcells19.9
CD56+_NKCells9.15
CD71+_EarlyErythroid6.55
CD8+_Tcells9.05
CardiacMyocytes9.85
Caudatenucleus7.05
Cerebellum6.65
CerebellumPeduncles9.3
CiliaryGanglion5.7
CingulateCortex9.2
Colorectaladenocarcinoma7.7
DorsalRootGanglion7.35
FetalThyroid8
Fetalbrain8.25
Fetalliver6.85
Fetallung6.6
GlobusPallidus6.1
Heart11.85
Hypothalamus9
Kidney6.55
Leukemia_chronicMyelogenousK-5627.1
Leukemia_promyelocytic-HL-606.7
Leukemialymphoblastic(MOLT-4)9.75
Liver10.75
Lung8.7
Lymphnode10.2
Lymphoma_burkitts(Daudi)11.35
Lymphoma_burkitts(Raji)11
MedullaOblongata9.75
OccipitalLobe7.4
OlfactoryBulb6.55
Ovary5.55
Pancreas14.25
PancreaticIslet8.4
ParietalLobe8.6
Pituitary10.6
Placenta8.8
Pons10.7
PrefrontalCortex9.6
Prostate9.3
Salivarygland6.5
SkeletalMuscle11.75
Skin6.95
SmoothMuscle9.55
Spinalcord8.75
SubthalamicNucleus9
SuperiorCervicalGanglion9.25
TemporalLobe7.45
Testis7.05
TestisGermCell6.9
TestisIntersitial6.9
TestisLeydigCell8
TestisSeminiferousTubule6.95
Thalamus7.85
Thymus9.7
Thyroid10.4
Tongue10.65
Tonsil13.5
Trachea6.9
TrigeminalGanglion8.8
Uterus6.75
UterusCorpus7.3
WholeBlood15.65
Wholebrain7.05
colon8.05
pineal_day8.6
pineal_night8.8
retina9.25
small_intestine8.5
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P335305
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.84 ± 0.42
Basal Forebrain5.32 ± 0.58
Basal Part of Pons4.61 ± 0.35
Cerebellar Cortex4.61 ± 0.28
Cerebellar Nuclei5.09 ± 0.59
Claustrum5.19 ± 0.67
Epithalamus5.02 ± 0.4
Frontal Lobe4.8 ± 0.55
Globus Pallidus6.5 ± 0.3
Hypothalamus4.62 ± 0.6
Insula4.65 ± 0.39
Limbic Lobe4.92 ± 0.67
Mesencephalon5.01 ± 0.55
Myelencephalon5.16 ± 0.64
Occipital Lobe5.26 ± 0.5
Parietal Lobe4.95 ± 0.57
Pontine Tegmentum5.04 ± 0.62
Striatum5.41 ± 0.54
Subthalamus4.55 ± 1.01
Temporal Lobe4.85 ± 0.5
Thalamus5.3 ± 0.36
White Matter6.07 ± 0.51
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Oas3CBCerebellum5
5.61
Oas3CTXCerebral cortex0.97
1.01
Oas3HIPHippocampal region1.29
1.45
Oas3HPFHippocampal formation1.1
1.5
Oas3HYHypothalamus0.16
0.32
Oas3LSXLateral septal complex0.04
0
Oas3MBMidbrain0.27
0.42
Oas3MYMedulla2.72
2.23
Oas3OLFOlfactory bulb1.64
1.18
Oas3PPons0.45
0.45
Oas3PALPallidum0.2
0.23
Oas3RHPRetrohippocampal region0.79
1.72
Oas3sAMYStriatum-like amygdalar nuclei0.6
0.53
Oas3STRStriatum0.38
0.38
Oas3STRdStriatum dorsal region0.39
0.42
Oas3STRvStriatum ventral region0.46
0.39
Oas3THThalamus0.42
0.47
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
OAS3_HUMAN_1 13 1 13 MDLYSTPAAALDR PRIDE
OAS3_HUMAN_1036 18 1036 1053 PIILDPADPTGNLGHNAR PRIDE
OAS3_HUMAN_1041 13 1041 1053 PADPTGNLGHNAR PRIDE
PAp00000338 17 348 364 AGCSGLGHPIQLDPNQK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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