AutismKB 2.0

Annotation Detail for OGDH


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Basic Information Top
Gene Symbol:OGDH ( AKGDH,E1k,OGDC )
Gene Full Name: oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
Band: 7p13
Quick LinksEntrez ID:4967; OMIM: 613022; Uniprot ID:ODO1_HUMAN; ENSEMBL ID: ENSG00000105953; HGNC ID: 8124
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body6 / 7076184
blastocyst8 / 62319128
fetus73 / 564012129
neonate11 / 31097353
infant2 / 2362084
juvenile5 / 5555689
adult335 / 1939121172
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor2 / 12794156
bladder carcinoma2 / 17475114
breast (mammary gland) tumor53 / 94178562
cervical tumor9 / 34366261
chondrosarcoma11 / 82823132
colorectal tumor13 / 114246113
esophageal tumor0 / 172900 
gastrointestinal tumor15 / 119369125
germ cell tumor53 / 263845200
glioma18 / 106883168
head and neck tumor64 / 136302469
kidney tumor19 / 68959275
leukemia9 / 9584293
liver tumor28 / 96359290
lung tumor26 / 103127252
lymphoma10 / 71755139
non-neoplasia12 / 97250123
normal690 / 3360307205
ovarian tumor7 / 7668291
pancreatic tumor31 / 104616296
primitive neuroectodermal tumor of the CNS15 / 125680119
prostate cancer41 / 102680399
retinoblastoma6 / 46356129
skin tumor18 / 124949144
soft tissue/muscle tissue tumor13 / 125191103
uterine tumor7 / 9025777
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue2 / 13106152
adrenal gland6 / 33197180
ascites3 / 4001574
bladder1 / 2975733
blood11 / 12347889
bone4 / 7165555
bone marrow2 / 4880140
brain457 / 1100989415
cervix11 / 48171228
connective tissue15 / 149255100
ear0 / 162120 
embryonic tissue22 / 215722101
esophagus0 / 202090 
eye31 / 211054146
heart16 / 89626178
intestine27 / 234472115
kidney37 / 211777174
larynx5 / 24145207
liver38 / 207743182
lung58 / 336974172
lymph7 / 44270158
lymph node5 / 9161054
mammary gland58 / 153271378
mouth47 / 67052700
muscle19 / 107715176
nerve1 / 1576863
ovary14 / 102051137
pancreas45 / 214812209
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta56 / 280825199
prostate57 / 189345301
salivary gland10 / 20155496
skin29 / 210574137
spleen4 / 5395274
stomach11 / 96619113
testis120 / 330442363
thymus13 / 81131160
thyroid17 / 47473358
tonsil1 / 1699958
trachea39 / 52413744
umbilical cord16 / 136801169
uterus38 / 232878163
vascular3 / 5178057
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 201282_at
Cell line Expression level Expression bar
721_B_lymphoblasts136.9
Adipocyte11.45
AdrenalCortex32.9
Adrenalgland46.05
Amygdala22.75
Appendix7.4
AtrioventricularNode6.4
BDCA4+_DentriticCells36.45
Bonemarrow9
BronchialEpithelialCells13.75
CD105+_Endothelial7.05
CD14+_Monocytes83.75
CD19+_BCells(neg._sel.)8.3
CD33+_Myeloid42.3
CD34+11.5
CD4+_Tcells31.3
CD56+_NKCells29.45
CD71+_EarlyErythroid123.1
CD8+_Tcells36.1
CardiacMyocytes9.45
Caudatenucleus8.4
Cerebellum16.8
CerebellumPeduncles13.35
CiliaryGanglion5.2
CingulateCortex8.85
Colorectaladenocarcinoma83.9
DorsalRootGanglion5.75
FetalThyroid9.65
Fetalbrain7.4
Fetalliver5.75
Fetallung6.1
GlobusPallidus6.1
Heart283.7
Hypothalamus8.7
Kidney60.6
Leukemia_chronicMyelogenousK-5626.8
Leukemia_promyelocytic-HL-6010.45
Leukemialymphoblastic(MOLT-4)4.85
Liver23.75
Lung39.8
Lymphnode6.4
Lymphoma_burkitts(Daudi)10.85
Lymphoma_burkitts(Raji)122.85
MedullaOblongata8.6
OccipitalLobe15.85
OlfactoryBulb7.95
Ovary4.15
Pancreas5.25
PancreaticIslet8.2
ParietalLobe8.7
Pituitary9.35
Placenta62.65
Pons8
PrefrontalCortex102.7
Prostate45.15
Salivarygland5.3
SkeletalMuscle57.9
Skin5.55
SmoothMuscle9.15
Spinalcord7.7
SubthalamicNucleus9.05
SuperiorCervicalGanglion8.9
TemporalLobe13.65
Testis7.6
TestisGermCell8
TestisIntersitial4.85
TestisLeydigCell6.8
TestisSeminiferousTubule6.9
Thalamus7.8
Thymus15.75
Thyroid144.65
Tongue11.4
Tonsil9.05
Trachea6.3
TrigeminalGanglion8.8
Uterus34.45
UterusCorpus5.2
WholeBlood31.15
Wholebrain59.9
colon15.25
pineal_day65.34
pineal_night44.8
retina81.65
small_intestine21.35
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_7702_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala8.08 ± 0.51
Basal Forebrain7.89 ± 0.39
Basal Part of Pons7.83 ± 0.44
Cerebellar Cortex7.86 ± 0.41
Cerebellar Nuclei8.23 ± 0.37
Claustrum8.22 ± 0.56
Epithalamus7.81 ± 0.36
Frontal Lobe7.8 ± 0.46
Globus Pallidus8.39 ± 0.22
Hypothalamus7.72 ± 0.42
Insula7.67 ± 0.38
Limbic Lobe8 ± 0.48
Mesencephalon8.05 ± 0.51
Myelencephalon7.98 ± 0.4
Occipital Lobe8.2 ± 0.46
Parietal Lobe7.97 ± 0.43
Pontine Tegmentum8 ± 0.33
Striatum8.07 ± 0.48
Subthalamus8.26 ± 0.08
Temporal Lobe7.77 ± 0.37
Thalamus7.95 ± 0.37
White Matter8.21 ± 0.41
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
OgdhCBCerebellum63.04
100
OgdhCTXCerebral cortex100
100
OgdhHIPHippocampal region100
100
OgdhHPFHippocampal formation100
100
OgdhHYHypothalamus100
100
OgdhLSXLateral septal complex100
100
OgdhMBMidbrain100
100
OgdhMYMedulla100
100
OgdhOLFOlfactory bulb100
100
OgdhPPons94.77
100
OgdhPALPallidum100
100
OgdhRHPRetrohippocampal region100
100
OgdhsAMYStriatum-like amygdalar nuclei100
100
OgdhSTRStriatum100
100
OgdhSTRdStriatum dorsal region100
100
OgdhSTRvStriatum ventral region100
100
OgdhTHThalamus100
100
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
ODO1_HUMAN_0 0 0 0 IEQLSPFPFDLLLK PRIDE
ODO1_HUMAN_0 0 0 0 SMSCPSTGLTEDILTHIGNVASSVPVENFTIHGGLSR PRIDE
ODO1_HUMAN_236 16 236 251 QKFETPGIMQFTNEEK PRIDE
ODO1_HUMAN_238 14 238 251 FETPGIMQFTNEEK PRIDE
ODO1_HUMAN_277 14 277 290 FGLEGCEVLIPALK PRIDE
ODO1_HUMAN_364 23 364 386 NITLSLVANPSHLEAADPVVMGK PRIDE
ODO1_HUMAN_457 10 457 466 SSPYPTDVAR PRIDE
ODO1_HUMAN_565 8 565 572 ICEEAFAR PRIDE
ODO1_HUMAN_600 37 600 636 SMSCPSTGLTEDILTHIGNVASSVPVENFTIHGGLSR PRIDE
ODO1_HUMAN_772 26 772 797 QNGIVLLLPHGMEGMGPEHSSARPER PRIDE
ODO1_HUMAN_870 14 870 883 SSFDEMLPGTHFQR PRIDE
ODO1_HUMAN_883 16 883 898 VIPEDGPAAQNPENVK PRIDE
ODO1_HUMAN_919 10 919 928 DMVGQVAITR PRIDE
ODO1_HUMAN_929 14 929 942 IEQLSPFPFDLLLK PRIDE
PAp00000300 13 390 402 AEQFYCGDTEGKK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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