AutismKB 2.0

Annotation Detail for P2RX1


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Basic Information Top
Gene Symbol:P2RX1 ( P2X1 )
Gene Full Name: purinergic receptor P2X, ligand-gated ion channel, 1
Band: 17p13.3
Quick LinksEntrez ID:5023; OMIM: 600845; Uniprot ID:P2RX1_HUMAN; ENSEMBL ID: ENSG00000108405; HGNC ID: 8533
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus0 / 5640120 
neonate4 / 31097128
infant0 / 236200 
juvenile0 / 555560 
adult20 / 193912110
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor1 / 2638453
glioma0 / 1068830 
head and neck tumor0 / 1363020 
kidney tumor0 / 689590 
leukemia12 / 95842125
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal40 / 336030711
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood14 / 123478113
bone0 / 716550 
bone marrow4 / 4880181
brain1 / 11009890 
cervix0 / 481710 
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye0 / 2110540 
heart1 / 8962611
intestine6 / 23447225
kidney1 / 2117774
larynx0 / 241450 
liver0 / 2077430 
lung1 / 3369742
lymph0 / 442700 
lymph node1 / 9161010
mammary gland0 / 1532710 
mouth0 / 670520 
muscle0 / 1077150 
nerve0 / 157680 
ovary2 / 10205119
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta4 / 28082514
prostate5 / 18934526
salivary gland0 / 201550 
skin0 / 2105740 
spleen6 / 53952111
stomach0 / 966190 
testis2 / 3304426
thymus2 / 8113124
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord3 / 13680219
uterus8 / 23287834
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 210401_at
Cell line Expression level Expression bar
721_B_lymphoblasts7.35
Adipocyte5.8
AdrenalCortex6.05
Adrenalgland4.9
Amygdala6.2
Appendix5.9
AtrioventricularNode4.75
BDCA4+_DentriticCells38.1
Bonemarrow10.8
BronchialEpithelialCells5.55
CD105+_Endothelial5.9
CD14+_Monocytes38
CD19+_BCells(neg._sel.)17
CD33+_Myeloid73.3
CD34+67.95
CD4+_Tcells6.15
CD56+_NKCells8
CD71+_EarlyErythroid5.5
CD8+_Tcells5.65
CardiacMyocytes7.3
Caudatenucleus5.15
Cerebellum4.65
CerebellumPeduncles6.55
CiliaryGanglion4.2
CingulateCortex6.75
Colorectaladenocarcinoma5.8
DorsalRootGanglion4.55
FetalThyroid5.6
Fetalbrain5.8
Fetalliver5.05
Fetallung4.75
GlobusPallidus4.25
Heart7.4
Hypothalamus6.05
Kidney4.7
Leukemia_chronicMyelogenousK-5625.9
Leukemia_promyelocytic-HL-605.15
Leukemialymphoblastic(MOLT-4)4.7
Liver7.6
Lung6.4
Lymphnode9.2
Lymphoma_burkitts(Daudi)12.05
Lymphoma_burkitts(Raji)8.15
MedullaOblongata5.2
OccipitalLobe5.1
OlfactoryBulb5.9
Ovary3.85
Pancreas20.7
PancreaticIslet7.9
ParietalLobe6.9
Pituitary6.8
Placenta6.05
Pons5.5
PrefrontalCortex6.7
Prostate6.75
Salivarygland4.7
SkeletalMuscle8.7
Skin4.45
SmoothMuscle6.55
Spinalcord6.15
SubthalamicNucleus5.3
SuperiorCervicalGanglion8
TemporalLobe5
Testis5.05
TestisGermCell7.65
TestisIntersitial5.2
TestisLeydigCell5.75
TestisSeminiferousTubule5
Thalamus5.9
Thymus4.95
Thyroid7.35
Tongue6.35
Tonsil5.65
Trachea4.85
TrigeminalGanglion6.05
Uterus4.8
UterusCorpus8.15
WholeBlood19.85
Wholebrain4.6
colon5.75
pineal_day6.86
pineal_night6.88
retina5.925
small_intestine5.65
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_9497_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.22 ± 1.08
Basal Forebrain1.79 ± 0.21
Basal Part of Pons1.51 ± 0.39
Cerebellar Cortex1.63 ± 0.73
Cerebellar Nuclei2.13 ± 0.74
Claustrum2.63 ± 0.87
Epithalamus1.61 ± 0.89
Frontal Lobe1.64 ± 0.69
Globus Pallidus2.56 ± 0.55
Hypothalamus1.81 ± 0.78
Insula1.84 ± 0.9
Limbic Lobe1.79 ± 0.6
Mesencephalon1.98 ± 0.68
Myelencephalon1.84 ± 0.74
Occipital Lobe1.99 ± 0.61
Parietal Lobe1.81 ± 0.83
Pontine Tegmentum1.87 ± 0.83
Striatum2.03 ± 0.55
Subthalamus1.9 ± 0.71
Temporal Lobe1.69 ± 0.66
Thalamus1.84 ± 0.68
White Matter2.45 ± 0.56
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
P2rx1CBCerebellum1.08
1.97
P2rx1CTXCerebral cortex0.33
0.37
P2rx1HIPHippocampal region0.23
0.24
P2rx1HPFHippocampal formation0.25
0.29
P2rx1HYHypothalamus0.31
0.56
P2rx1LSXLateral septal complex0.12
0.04
P2rx1MBMidbrain0.32
0.38
P2rx1MYMedulla1.45
1.94
P2rx1OLFOlfactory bulb2.01
2.63
P2rx1PPons0.29
0.36
P2rx1PALPallidum0.27
0.21
P2rx1RHPRetrohippocampal region0.27
0.36
P2rx1sAMYStriatum-like amygdalar nuclei0.34
0.22
P2rx1STRStriatum0.22
0.21
P2rx1STRdStriatum dorsal region0.18
0.24
P2rx1STRvStriatum ventral region0.37
0.21
P2rx1THThalamus0.46
0.78
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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