AutismKB 2.0

Annotation Detail for P2RX4


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:P2RX4 ( P2X4,P2X4R )
Gene Full Name: purinergic receptor P2X, ligand-gated ion channel, 4
Band: 12q24.31
Quick LinksEntrez ID:5025; OMIM: 600846; Uniprot ID:P2RX4_HUMAN; ENSEMBL ID: ENSG00000135124; HGNC ID: 8535
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst0 / 623190 
fetus24 / 56401242
neonate0 / 310970 
infant0 / 236200 
juvenile2 / 5555635
adult82 / 193912142
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor3 / 9417831
cervical tumor0 / 343660 
chondrosarcoma2 / 8282324
colorectal tumor6 / 11424652
esophageal tumor0 / 172900 
gastrointestinal tumor8 / 11936967
germ cell tumor4 / 26384515
glioma0 / 1068830 
head and neck tumor2 / 13630214
kidney tumor3 / 6895943
leukemia4 / 9584241
liver tumor1 / 9635910
lung tumor6 / 10312758
lymphoma0 / 717550 
non-neoplasia5 / 9725051
normal129 / 336030738
ovarian tumor2 / 7668226
pancreatic tumor4 / 10461638
primitive neuroectodermal tumor of the CNS2 / 12568015
prostate cancer1 / 1026809
retinoblastoma0 / 463560 
skin tumor3 / 12494924
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor2 / 9025722
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites1 / 4001524
bladder1 / 2975733
blood15 / 123478121
bone1 / 7165513
bone marrow0 / 488010 
brain13 / 110098911
cervix0 / 481710 
connective tissue6 / 14925540
ear0 / 162120 
embryonic tissue4 / 21572218
esophagus0 / 202090 
eye2 / 2110549
heart3 / 8962633
intestine15 / 23447263
kidney10 / 21177747
larynx0 / 241450 
liver3 / 20774314
lung15 / 33697444
lymph0 / 442700 
lymph node0 / 916100 
mammary gland3 / 15327119
mouth1 / 6705214
muscle2 / 10771518
nerve0 / 157680 
ovary2 / 10205119
pancreas12 / 21481255
parathyroid2 / 2053997
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta23 / 28082581
prostate4 / 18934521
salivary gland0 / 201550 
skin3 / 21057414
spleen4 / 5395274
stomach6 / 9661962
testis8 / 33044224
thymus0 / 811310 
thyroid1 / 4747321
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord0 / 136800 
uterus3 / 23287812
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 204088_at
Cell line Expression level Expression bar
721_B_lymphoblasts22.45
Adipocyte4.05
AdrenalCortex4.15
Adrenalgland3.85
Amygdala4.1
Appendix5.3
AtrioventricularNode3
BDCA4+_DentriticCells13.55
Bonemarrow3.9
BronchialEpithelialCells3.8
CD105+_Endothelial3.85
CD14+_Monocytes27.35
CD19+_BCells(neg._sel.)5.75
CD33+_Myeloid50.55
CD34+5.05
CD4+_Tcells16.35
CD56+_NKCells7.95
CD71+_EarlyErythroid3.65
CD8+_Tcells11.2
CardiacMyocytes5.1
Caudatenucleus3.45
Cerebellum9
CerebellumPeduncles8.2
CiliaryGanglion2.8
CingulateCortex3.95
Colorectaladenocarcinoma10.8
DorsalRootGanglion3
FetalThyroid3.75
Fetalbrain3.9
Fetalliver6.45
Fetallung3.65
GlobusPallidus2.95
Heart6.65
Hypothalamus4.3
Kidney8.8
Leukemia_chronicMyelogenousK-5623.6
Leukemia_promyelocytic-HL-603.4
Leukemialymphoblastic(MOLT-4)3.95
Liver5.85
Lung84
Lymphnode4.75
Lymphoma_burkitts(Daudi)5.05
Lymphoma_burkitts(Raji)5.6
MedullaOblongata5.4
OccipitalLobe3.45
OlfactoryBulb3.2
Ovary2.65
Pancreas6.7
PancreaticIslet13.6
ParietalLobe4.15
Pituitary6.3
Placenta44.75
Pons3.8
PrefrontalCortex4.85
Prostate37.7
Salivarygland3.2
SkeletalMuscle4.65
Skin3.1
SmoothMuscle4.45
Spinalcord5.25
SubthalamicNucleus3.6
SuperiorCervicalGanglion4.5
TemporalLobe3.55
Testis4.45
TestisGermCell3.3
TestisIntersitial3.25
TestisLeydigCell3.9
TestisSeminiferousTubule3.3
Thalamus4
Thymus3.15
Thyroid9.8
Tongue3.9
Tonsil3.8
Trachea4.4
TrigeminalGanglion4.05
Uterus3.4
UterusCorpus3.55
WholeBlood6.55
Wholebrain3.65
colon21.05
pineal_day4.94
pineal_night4.78
retina4.825
small_intestine20.55
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_16153_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.04 ± 0.47
Basal Forebrain4.36 ± 0.4
Basal Part of Pons4.84 ± 0.42
Cerebellar Cortex5.29 ± 0.29
Cerebellar Nuclei4.94 ± 0.34
Claustrum5.06 ± 0.52
Epithalamus4.91 ± 0.59
Frontal Lobe4.47 ± 0.4
Globus Pallidus4.72 ± 0.45
Hypothalamus4.51 ± 0.3
Insula4.68 ± 0.32
Limbic Lobe4.68 ± 0.52
Mesencephalon4.55 ± 0.51
Myelencephalon4.68 ± 0.56
Occipital Lobe5.04 ± 0.55
Parietal Lobe4.71 ± 0.56
Pontine Tegmentum4.72 ± 0.55
Striatum4.28 ± 0.46
Subthalamus4.64 ± 0.68
Temporal Lobe4.77 ± 0.49
Thalamus4.66 ± 0.46
White Matter5.25 ± 0.16
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
P2rx4CBCerebellum34.23
44.26
P2rx4CTXCerebral cortex64.52
36.2
P2rx4HIPHippocampal region24.41
19.98
P2rx4HPFHippocampal formation37.8
24.95
P2rx4HYHypothalamus11.11
4.3
P2rx4LSXLateral septal complex58.47
25.98
P2rx4MBMidbrain17.1
9.88
P2rx4MYMedulla37.65
30.02
P2rx4OLFOlfactory bulb53.89
26.55
P2rx4PPons32.71
20.48
P2rx4PALPallidum26.77
11.81
P2rx4RHPRetrohippocampal region55.06
29.91
P2rx4sAMYStriatum-like amygdalar nuclei15.89
5.46
P2rx4STRStriatum38.52
14.29
P2rx4STRdStriatum dorsal region38.54
14.46
P2rx4STRvStriatum ventral region41.42
14.14
P2rx4THThalamus28.6
15.81
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00007022 21 128 148 SDASCTAGSAGTHSNGVSTGR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved