AutismKB 2.0

Annotation Detail for DUOX2


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Basic Information Top
Gene Symbol:DUOX2 ( LNOX2,NOXEF2,P138-TOX,TDH6,THOX2 )
Gene Full Name: dual oxidase 2
Band: 15q21.1
Quick LinksEntrez ID:50506; OMIM: 606759; Uniprot ID:DUOX2_HUMAN; ENSEMBL ID: ENSG00000140279; HGNC ID: 13273
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus0 / 5640120 
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult42 / 193912121
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor11 / 11424696
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor0 / 2638450 
glioma0 / 1068830 
head and neck tumor12 / 13630288
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia1 / 9725010
normal146 / 336030743
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain1 / 11009890 
cervix2 / 4817141
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye1 / 2110544
heart0 / 896260 
intestine15 / 23447263
kidney0 / 2117770 
larynx0 / 241450 
liver1 / 2077434
lung1 / 3369742
lymph0 / 442700 
lymph node0 / 916100 
mammary gland0 / 1532710 
mouth4 / 6705259
muscle1 / 1077159
nerve0 / 157680 
ovary0 / 1020510 
pancreas6 / 21481227
parathyroid0 / 205390 
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate4 / 18934521
salivary gland0 / 201550 
skin125 / 210574593
spleen0 / 539520 
stomach0 / 966190 
testis0 / 3304420 
thymus0 / 811310 
thyroid11 / 47473231
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord0 / 136800 
uterus3 / 23287812
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 219727_at
Cell line Expression level Expression bar
721_B_lymphoblasts5.65
Adipocyte4.85
AdrenalCortex5.8
Adrenalgland4.4
Amygdala5.1
Appendix6.15
AtrioventricularNode4.4
BDCA4+_DentriticCells5
Bonemarrow5.2
BronchialEpithelialCells4.85
CD105+_Endothelial5
CD14+_Monocytes5.3
CD19+_BCells(neg._sel.)5.2
CD33+_Myeloid6.15
CD34+5.95
CD4+_Tcells5.2
CD56+_NKCells5.6
CD71+_EarlyErythroid4.7
CD8+_Tcells4.6
CardiacMyocytes6.9
Caudatenucleus4.5
Cerebellum4.6
CerebellumPeduncles5.95
CiliaryGanglion3.75
CingulateCortex5.15
Colorectaladenocarcinoma5
DorsalRootGanglion4.25
FetalThyroid32.5
Fetalbrain4.9
Fetalliver4.45
Fetallung4
GlobusPallidus3.75
Heart7.55
Hypothalamus5.15
Kidney4.5
Leukemia_chronicMyelogenousK-5624.5
Leukemia_promyelocytic-HL-604.4
Leukemialymphoblastic(MOLT-4)3.9
Liver6.9
Lung5.4
Lymphnode4.35
Lymphoma_burkitts(Daudi)6.5
Lymphoma_burkitts(Raji)7.25
MedullaOblongata4.55
OccipitalLobe4.45
OlfactoryBulb3.9
Ovary3.4
Pancreas4.15
PancreaticIslet64.35
ParietalLobe5.45
Pituitary7.35
Placenta5
Pons4.75
PrefrontalCortex6
Prostate5.7
Salivarygland4.1
SkeletalMuscle7.4
Skin4.4
SmoothMuscle5.55
Spinalcord5.35
SubthalamicNucleus4.75
SuperiorCervicalGanglion12.95
TemporalLobe4.7
Testis4.3
TestisGermCell4.1
TestisIntersitial4.3
TestisLeydigCell5.1
TestisSeminiferousTubule4.3
Thalamus5.1
Thymus3.85
Thyroid411.65
Tongue5.9
Tonsil4.9
Trachea6.65
TrigeminalGanglion5.75
Uterus3.95
UterusCorpus4.65
WholeBlood5.35
Wholebrain4.05
colon5.05
pineal_day6.1
pineal_night6
retina6.025
small_intestine4.75
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P35905
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.16 ± 0.95
Basal Forebrain1.76 ± 0.18
Basal Part of Pons1.45 ± 0.33
Cerebellar Cortex1.59 ± 0.7
Cerebellar Nuclei2.11 ± 0.68
Claustrum2.67 ± 0.87
Epithalamus1.52 ± 0.78
Frontal Lobe1.59 ± 0.57
Globus Pallidus2.37 ± 0.36
Hypothalamus1.8 ± 0.62
Insula1.91 ± 1.06
Limbic Lobe1.77 ± 0.59
Mesencephalon1.91 ± 0.64
Myelencephalon1.79 ± 0.64
Occipital Lobe1.89 ± 0.75
Parietal Lobe1.72 ± 0.58
Pontine Tegmentum1.82 ± 0.67
Striatum1.98 ± 0.56
Subthalamus1.91 ± 0.62
Temporal Lobe1.68 ± 0.64
Thalamus1.77 ± 0.59
White Matter2.29 ± 0.43
Mouse Brain ISH
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018