AutismKB 2.0

Annotation Detail for NOX4


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Basic Information Top
Gene Symbol:NOX4 ( KOX,KOX-1,RENOX )
Gene Full Name: NADPH oxidase 4
Band: 11q14.3
Quick LinksEntrez ID:50507; OMIM: 605261; Uniprot ID:NOX4_HUMAN; ENSEMBL ID: ENSG00000086991; HGNC ID: 7891
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body2 / 7076128
blastocyst1 / 6231916
fetus2 / 5640123
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult23 / 193912111
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor2 / 9417821
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor2 / 11936916
germ cell tumor3 / 26384511
glioma1 / 1068839
head and neck tumor6 / 13630244
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia2 / 9725020
normal58 / 336030717
ovarian tumor0 / 766820 
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor3 / 12519123
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain4 / 11009893
cervix0 / 481710 
connective tissue5 / 14925533
ear0 / 162120 
embryonic tissue4 / 21572218
esophagus0 / 202090 
eye2 / 2110549
heart0 / 896260 
intestine1 / 2344724
kidney39 / 211777184
larynx0 / 241450 
liver0 / 2077430 
lung0 / 3369740 
lymph0 / 442700 
lymph node0 / 916100 
mammary gland2 / 15327113
mouth6 / 6705289
muscle0 / 1077150 
nerve0 / 157680 
ovary3 / 10205129
pancreas1 / 2148124
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta1 / 2808253
prostate0 / 1893450 
salivary gland0 / 201550 
skin0 / 2105740 
spleen0 / 539520 
stomach2 / 9661920
testis1 / 3304423
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus5 / 23287821
vascular3 / 5178057
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 219773_at
Cell line Expression level Expression bar
721_B_lymphoblasts6.05
Adipocyte5.15
AdrenalCortex6
Adrenalgland4.65
Amygdala5.4
Appendix6.55
AtrioventricularNode4.5
BDCA4+_DentriticCells5.45
Bonemarrow5.5
BronchialEpithelialCells5.2
CD105+_Endothelial5.2
CD14+_Monocytes5.5
CD19+_BCells(neg._sel.)5.55
CD33+_Myeloid6.5
CD34+6.35
CD4+_Tcells5.45
CD56+_NKCells5.95
CD71+_EarlyErythroid5.05
CD8+_Tcells4.9
CardiacMyocytes7.95
Caudatenucleus4.75
Cerebellum4.35
CerebellumPeduncles6.35
CiliaryGanglion4.35
CingulateCortex5.5
Colorectaladenocarcinoma5.3
DorsalRootGanglion4.2
FetalThyroid5.15
Fetalbrain5.2
Fetalliver4.65
Fetallung4.25
GlobusPallidus4.05
Heart7.15
Hypothalamus5.55
Kidney130.2
Leukemia_chronicMyelogenousK-5624.75
Leukemia_promyelocytic-HL-604.65
Leukemialymphoblastic(MOLT-4)4.15
Liver7.25
Lung5.7
Lymphnode4.45
Lymphoma_burkitts(Daudi)6.9
Lymphoma_burkitts(Raji)7.85
MedullaOblongata4.75
OccipitalLobe4.65
OlfactoryBulb4.1
Ovary3.65
Pancreas4.3
PancreaticIslet5.7
ParietalLobe5.75
Pituitary6.1
Placenta5.35
Pons7.4
PrefrontalCortex6.5
Prostate6.05
Salivarygland8.3
SkeletalMuscle7.35
Skin4.4
SmoothMuscle9.05
Spinalcord5.6
SubthalamicNucleus4.9
SuperiorCervicalGanglion8.35
TemporalLobe4.9
Testis4.5
TestisGermCell4.35
TestisIntersitial4.5
TestisLeydigCell5.35
TestisSeminiferousTubule4.5
Thalamus5.45
Thymus4.1
Thyroid6.55
Tongue5.5
Tonsil5.2
Trachea4.4
TrigeminalGanglion6.2
Uterus4.3
UterusCorpus6.3
WholeBlood5.7
Wholebrain4.25
colon5.3
pineal_day6.56
pineal_night6.4
retina6.4
small_intestine5.05
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_17000_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.39 ± 1.03
Basal Forebrain2.01 ± 0.23
Basal Part of Pons1.63 ± 0.35
Cerebellar Cortex1.75 ± 0.61
Cerebellar Nuclei2.23 ± 0.67
Claustrum2.9 ± 0.93
Epithalamus1.67 ± 0.78
Frontal Lobe1.8 ± 0.62
Globus Pallidus2.66 ± 0.54
Hypothalamus1.96 ± 0.64
Insula2.22 ± 1.51
Limbic Lobe1.95 ± 0.63
Mesencephalon2.15 ± 0.69
Myelencephalon1.98 ± 0.65
Occipital Lobe2.07 ± 0.62
Parietal Lobe2.01 ± 0.68
Pontine Tegmentum2.01 ± 0.7
Striatum2.14 ± 0.63
Subthalamus2.14 ± 0.74
Temporal Lobe1.83 ± 0.58
Thalamus1.94 ± 0.62
White Matter2.76 ± 0.54
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Nox4CBCerebellum0.28
0.81
Nox4CTXCerebral cortex0.91
0.9
Nox4HIPHippocampal region1.09
0.98
Nox4HPFHippocampal formation0.85
0.82
Nox4HYHypothalamus1.65
2.38
Nox4LSXLateral septal complex0.05
0
Nox4MBMidbrain0.98
1.8
Nox4MYMedulla0.08
0.11
Nox4OLFOlfactory bulb0.2
0.29
Nox4PPons0.47
2.08
Nox4PALPallidum0.07
0.05
Nox4RHPRetrohippocampal region0.46
0.61
Nox4sAMYStriatum-like amygdalar nuclei0.23
0.31
Nox4STRStriatum0.25
0.6
Nox4STRdStriatum dorsal region0.33
0.87
Nox4STRvStriatum ventral region0.11
0.12
Nox4THThalamus1.02
1.32
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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