AutismKB 2.0

Annotation Detail for SERPINE1


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Basic Information Top
Gene Symbol:SERPINE1 ( PAI,PAI-1,PAI1,PLANH1 )
Gene Full Name: serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
Band: 7q22.1
Quick LinksEntrez ID:5054; OMIM: 173360; Uniprot ID:PAI1_HUMAN; ENSEMBL ID: ENSG00000106366; HGNC ID: 8583
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body114 / 707611611
blastocyst6 / 6231996
fetus44 / 56401278
neonate31 / 31097996
infant0 / 236200 
juvenile7 / 55556125
adult453 / 1939121233
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma3 / 17475171
breast (mammary gland) tumor2 / 9417821
cervical tumor2 / 3436658
chondrosarcoma59 / 82823712
colorectal tumor5 / 11424643
esophageal tumor1 / 1729057
gastrointestinal tumor10 / 11936983
germ cell tumor4 / 26384515
glioma8 / 10688374
head and neck tumor13 / 13630295
kidney tumor5 / 6895972
leukemia2 / 9584220
liver tumor35 / 96359363
lung tumor14 / 103127135
lymphoma1 / 7175513
non-neoplasia24 / 97250246
normal699 / 3360307208
ovarian tumor3 / 7668239
pancreatic tumor47 / 104616449
primitive neuroectodermal tumor of the CNS6 / 12568047
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor2 / 12494916
soft tissue/muscle tissue tumor5 / 12519139
uterine tumor4 / 9025744
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland0 / 331970 
ascites0 / 400150 
bladder1 / 2975733
blood2 / 12347816
bone32 / 71655446
bone marrow19 / 48801389
brain21 / 110098919
cervix3 / 4817162
connective tissue41 / 149255274
ear0 / 162120 
embryonic tissue122 / 215722565
esophagus1 / 2020949
eye16 / 21105475
heart1 / 8962611
intestine11 / 23447246
kidney11 / 21177751
larynx1 / 2414541
liver62 / 207743298
lung59 / 336974175
lymph0 / 442700 
lymph node1 / 9161010
mammary gland6 / 15327139
mouth0 / 670520 
muscle4 / 10771537
nerve3 / 15768190
ovary5 / 10205148
pancreas55 / 214812256
parathyroid0 / 205390 
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta210 / 280825747
prostate0 / 1893450 
salivary gland0 / 201550 
skin105 / 210574498
spleen0 / 539520 
stomach11 / 96619113
testis2 / 3304426
thymus3 / 8113136
thyroid15 / 47473315
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord34 / 136802485
uterus15 / 23287864
vascular68 / 517801313
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 202628_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts10.4
Adipocyte570.7
AdrenalCortex11.8
Adrenalgland19.4
Amygdala8.35
Appendix9.15
AtrioventricularNode8.75
BDCA4+_DentriticCells8.4
Bonemarrow9.1
BronchialEpithelialCells574.3
CD105+_Endothelial8.7
CD14+_Monocytes9.15
CD19+_BCells(neg._sel.)8.85
CD33+_Myeloid10.25
CD34+10.45
CD4+_Tcells9
CD56+_NKCells9.55
CD71+_EarlyErythroid8.4
CD8+_Tcells8.05
CardiacMyocytes7175.15
Caudatenucleus8.05
Cerebellum7.3
CerebellumPeduncles10.8
CiliaryGanglion10.9
CingulateCortex9.4
Colorectaladenocarcinoma5486.1
DorsalRootGanglion7.15
FetalThyroid8.85
Fetalbrain10.15
Fetalliver15.1
Fetallung349.3
GlobusPallidus6.85
Heart11.85
Hypothalamus9.35
Kidney8.3
Leukemia_chronicMyelogenousK-5628.15
Leukemia_promyelocytic-HL-607.8
Leukemialymphoblastic(MOLT-4)8.5
Liver13.45
Lung34.45
Lymphnode7.7
Lymphoma_burkitts(Daudi)11.65
Lymphoma_burkitts(Raji)12.65
MedullaOblongata8.2
OccipitalLobe8
OlfactoryBulb7.1
Ovary11.55
Pancreas13.05
PancreaticIslet77.6
ParietalLobe9.6
Pituitary10.55
Placenta1829.65
Pons8.7
PrefrontalCortex10.4
Prostate10.2
Salivarygland7.25
SkeletalMuscle11.3
Skin7.1
SmoothMuscle9856.85
Spinalcord12.55
SubthalamicNucleus8.3
SuperiorCervicalGanglion11.1
TemporalLobe8.25
Testis7.65
TestisGermCell7.4
TestisIntersitial7.5
TestisLeydigCell8.95
TestisSeminiferousTubule10.35
Thalamus9.2
Thymus7.2
Thyroid11.35
Tongue9.05
Tonsil8.8
Trachea9.4
TrigeminalGanglion11.2
Uterus6.45
UterusCorpus8.3
WholeBlood9.25
Wholebrain7.15
colon8.65
pineal_day10.26
pineal_night10.2
retina11.25
small_intestine8.2
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P158089
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.2 ± 0.97
Basal Forebrain1.76 ± 0.21
Basal Part of Pons1.7 ± 0.6
Cerebellar Cortex1.63 ± 0.58
Cerebellar Nuclei2.03 ± 0.66
Claustrum2.59 ± 0.87
Epithalamus1.5 ± 0.79
Frontal Lobe1.71 ± 0.66
Globus Pallidus2.22 ± 0.35
Hypothalamus1.95 ± 0.65
Insula1.68 ± 0.47
Limbic Lobe1.92 ± 0.6
Mesencephalon1.98 ± 0.69
Myelencephalon1.91 ± 0.67
Occipital Lobe2 ± 0.77
Parietal Lobe1.86 ± 0.67
Pontine Tegmentum1.77 ± 0.63
Striatum2.16 ± 0.74
Subthalamus1.96 ± 0.64
Temporal Lobe1.76 ± 0.69
Thalamus1.86 ± 0.79
White Matter2.5 ± 0.64
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Serpine1CBCerebellum6.15
7.67
Serpine1CTXCerebral cortex4.84
3.74
Serpine1HIPHippocampal region5.04
4.81
Serpine1HPFHippocampal formation4.46
3.84
Serpine1HYHypothalamus2.04
1.53
Serpine1LSXLateral septal complex1.29
0.86
Serpine1MBMidbrain2.36
2.65
Serpine1MYMedulla3.27
3.44
Serpine1OLFOlfactory bulb4.97
3.34
Serpine1PPons4.73
5.5
Serpine1PALPallidum3.22
2.84
Serpine1RHPRetrohippocampal region3.54
2.51
Serpine1sAMYStriatum-like amygdalar nuclei5.46
4.04
Serpine1STRStriatum2.33
1.68
Serpine1STRdStriatum dorsal region1.61
1.19
Serpine1STRvStriatum ventral region3.77
2.47
Serpine1THThalamus5.03
3.61
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAI1_HUMAN_128 11 128 138 LVQGFMPHFFR PRIDE
PAI1_HUMAN_146 9 146 154 QVDFSEVER PRIDE
PAI1_HUMAN_311 13 311 323 KPLENLGMTDMFR PRIDE
PAI1_HUMAN_370 17 370 386 MAPEEIIMDRPFLFVVR PRIDE
PAp00132344 20 267 286 EVPLSALTNILSAQLISHWK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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