AutismKB 2.0

Annotation Detail for PAM


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Basic Information Top
Gene Symbol:PAM ( PAL,PHM )
Gene Full Name: peptidylglycine alpha-amidating monooxygenase
Band: 5q21.1
Quick LinksEntrez ID:5066; OMIM: 170270; Uniprot ID:AMD_HUMAN; ENSEMBL ID: ENSG00000145730; HGNC ID: 8596
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body19 / 70761268
blastocyst4 / 6231964
fetus64 / 564012113
neonate13 / 31097418
infant2 / 2362084
juvenile5 / 5555689
adult288 / 1939121148
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor5 / 12794390
bladder carcinoma0 / 174750 
breast (mammary gland) tumor8 / 9417884
cervical tumor1 / 3436629
chondrosarcoma22 / 82823265
colorectal tumor1 / 1142468
esophageal tumor0 / 172900 
gastrointestinal tumor32 / 119369268
germ cell tumor36 / 263845136
glioma7 / 10688365
head and neck tumor33 / 136302242
kidney tumor7 / 68959101
leukemia1 / 9584210
liver tumor5 / 9635951
lung tumor7 / 10312767
lymphoma1 / 7175513
non-neoplasia20 / 97250205
normal634 / 3360307188
ovarian tumor2 / 7668226
pancreatic tumor62 / 104616592
primitive neuroectodermal tumor of the CNS6 / 12568047
prostate cancer14 / 102680136
retinoblastoma0 / 463560 
skin tumor6 / 12494948
soft tissue/muscle tissue tumor3 / 12519123
uterine tumor27 / 90257299
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue2 / 13106152
adrenal gland9 / 33197271
ascites5 / 40015124
bladder0 / 297570 
blood5 / 12347840
bone6 / 7165583
bone marrow0 / 488010 
brain287 / 1100989260
cervix1 / 4817120
connective tissue46 / 149255308
ear7 / 16212431
embryonic tissue29 / 215722134
esophagus0 / 202090 
eye12 / 21105456
heart25 / 89626278
intestine11 / 23447246
kidney24 / 211777113
larynx2 / 2414582
liver9 / 20774343
lung32 / 33697494
lymph0 / 442700 
lymph node0 / 916100 
mammary gland18 / 153271117
mouth21 / 67052313
muscle10 / 10771592
nerve4 / 15768253
ovary3 / 10205129
pancreas109 / 214812507
parathyroid7 / 20539340
pharynx4 / 4132896
pituitary gland9 / 16585542
placenta56 / 280825199
prostate23 / 189345121
salivary gland0 / 201550 
skin26 / 210574123
spleen9 / 53952166
stomach22 / 96619227
testis42 / 330442127
thymus5 / 8113161
thyroid11 / 47473231
tonsil0 / 169990 
trachea84 / 524131602
umbilical cord1 / 1368073
uterus88 / 232878377
vascular19 / 51780366
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 202336_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts140.25
Adipocyte522.75
AdrenalCortex349.85
Adrenalgland480.05
Amygdala694.15
Appendix214.2
AtrioventricularNode62
BDCA4+_DentriticCells16.25
Bonemarrow23.1
BronchialEpithelialCells244.9
CD105+_Endothelial16.65
CD14+_Monocytes42.05
CD19+_BCells(neg._sel.)11.05
CD33+_Myeloid92.65
CD34+20.6
CD4+_Tcells45.95
CD56+_NKCells296.55
CD71+_EarlyErythroid9.65
CD8+_Tcells63.1
CardiacMyocytes241.55
Caudatenucleus620.15
Cerebellum114.6
CerebellumPeduncles95.3
CiliaryGanglion115.65
CingulateCortex254.5
Colorectaladenocarcinoma571.9
DorsalRootGanglion90.35
FetalThyroid396.1
Fetalbrain78.65
Fetalliver21.6
Fetallung217.35
GlobusPallidus130.2
Heart324.6
Hypothalamus931.45
Kidney219.8
Leukemia_chronicMyelogenousK-56218.5
Leukemia_promyelocytic-HL-609.25
Leukemialymphoblastic(MOLT-4)8.3
Liver24.3
Lung304.7
Lymphnode178.5
Lymphoma_burkitts(Daudi)16.35
Lymphoma_burkitts(Raji)41.15
MedullaOblongata257.55
OccipitalLobe214.9
OlfactoryBulb253.45
Ovary66.55
Pancreas199.7
PancreaticIslet1190.75
ParietalLobe130.8
Pituitary958.55
Placenta1092.7
Pons150.2
PrefrontalCortex360.2
Prostate247.6
Salivarygland762.3
SkeletalMuscle31.25
Skin58.9
SmoothMuscle697.5
Spinalcord216.45
SubthalamicNucleus158.8
SuperiorCervicalGanglion122.1
TemporalLobe154.85
Testis33.55
TestisGermCell112.9
TestisIntersitial39.8
TestisLeydigCell131.6
TestisSeminiferousTubule22.75
Thalamus388.9
Thymus38.3
Thyroid778.35
Tongue187.1
Tonsil23.3
Trachea817.85
TrigeminalGanglion75.75
Uterus573.9
UterusCorpus299.15
WholeBlood40.75
Wholebrain225.45
colon569.5
pineal_day1419.6
pineal_night1615.94
retina323.5
small_intestine481.25
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P933704
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.44 ± 0.4
Basal Forebrain7.36 ± 0.25
Basal Part of Pons7.99 ± 0.27
Cerebellar Cortex7.08 ± 0.15
Cerebellar Nuclei7.23 ± 0.57
Claustrum6.23 ± 0.45
Epithalamus7.3 ± 0.67
Frontal Lobe7.21 ± 0.4
Globus Pallidus7.04 ± 0.25
Hypothalamus8.19 ± 0.63
Insula7.45 ± 0.39
Limbic Lobe7.43 ± 0.48
Mesencephalon7.36 ± 0.48
Myelencephalon7.41 ± 0.55
Occipital Lobe7.92 ± 0.47
Parietal Lobe7.57 ± 0.37
Pontine Tegmentum7.47 ± 0.59
Striatum8.56 ± 0.45
Subthalamus7.77 ± 0.13
Temporal Lobe7.44 ± 0.33
Thalamus7.67 ± 0.32
White Matter5.45 ± 0.34
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
PamCBCerebellum23.02
31.98
PamCTXCerebral cortex100
100
PamHIPHippocampal region84.73
100
PamHPFHippocampal formation93.17
100
PamHYHypothalamus100
100
PamLSXLateral septal complex100
100
PamMBMidbrain100
100
PamMYMedulla71.54
100
PamOLFOlfactory bulb100
100
PamPPons69.34
96.95
PamPALPallidum77.53
98.68
PamRHPRetrohippocampal region100
100
PamsAMYStriatum-like amygdalar nuclei100
100
PamSTRStriatum84.04
93.44
PamSTRdStriatum dorsal region73.18
77.8
PamSTRvStriatum ventral region87.67
86.68
PamTHThalamus76.33
88.42
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00076308 27 261 287 QSPQLPQAFYPVGHPVDVSFGDLLAAR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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