AutismKB 2.0

Annotation Detail for PARK2


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Basic Information Top
Gene Symbol:PARK2 ( AR-JP,LPRS2,PDJ,PRKN )
Gene Full Name: parkinson protein 2, E3 ubiquitin protein ligase (parkin)
Band: 6q25.2-q27
Quick LinksEntrez ID:5071; OMIM: 602544; Uniprot ID:PRKN2_HUMAN; ENSEMBL ID: ENSG00000185345; HGNC ID:
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus6 / 56401210
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult7 / 19391213
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor0 / 2638450 
glioma0 / 1068830 
head and neck tumor2 / 13630214
kidney tumor1 / 6895914
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia2 / 9725020
normal49 / 336030714
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor2 / 12519115
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain34 / 110098930
cervix0 / 481710 
connective tissue3 / 14925520
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye4 / 21105418
heart0 / 896260 
intestine0 / 2344720 
kidney1 / 2117774
larynx0 / 241450 
liver0 / 2077430 
lung0 / 3369740 
lymph0 / 442700 
lymph node0 / 916100 
mammary gland0 / 1532710 
mouth2 / 6705229
muscle0 / 1077150 
nerve0 / 157680 
ovary0 / 1020510 
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta2 / 2808257
prostate2 / 18934510
salivary gland0 / 201550 
skin0 / 2105740 
spleen0 / 539520 
stomach1 / 9661910
testis9 / 33044227
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus4 / 23287817
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 207058_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts6.7
Adipocyte5.85
AdrenalCortex6.5
Adrenalgland5.25
Amygdala6
Appendix6.8
AtrioventricularNode4.9
BDCA4+_DentriticCells5.65
Bonemarrow6
BronchialEpithelialCells5.75
CD105+_Endothelial5.7
CD14+_Monocytes6.25
CD19+_BCells(neg._sel.)5.95
CD33+_Myeloid6.95
CD34+6.9
CD4+_Tcells6.05
CD56+_NKCells6.5
CD71+_EarlyErythroid5.5
CD8+_Tcells5.3
CardiacMyocytes7.7
Caudatenucleus5.25
Cerebellum4.75
CerebellumPeduncles6.9
CiliaryGanglion5.1
CingulateCortex6.1
Colorectaladenocarcinoma5.85
DorsalRootGanglion4.9
FetalThyroid5.7
Fetalbrain5.9
Fetalliver5.2
Fetallung4.65
GlobusPallidus5
Heart7.55
Hypothalamus6.45
Kidney5.5
Leukemia_chronicMyelogenousK-5625.3
Leukemia_promyelocytic-HL-605.15
Leukemialymphoblastic(MOLT-4)4.7
Liver7.85
Lung6.4
Lymphnode5.2
Lymphoma_burkitts(Daudi)7.55
Lymphoma_burkitts(Raji)8.25
MedullaOblongata5.4
OccipitalLobe5.75
OlfactoryBulb4.65
Ovary4.2
Pancreas5
PancreaticIslet6.3
ParietalLobe6.7
Pituitary6.9
Placenta5.8
Pons5.9
PrefrontalCortex7.25
Prostate6.8
Salivarygland4.75
SkeletalMuscle7.4
Skin5.6
SmoothMuscle6.65
Spinalcord6.15
SubthalamicNucleus5.45
SuperiorCervicalGanglion7.75
TemporalLobe5.4
Testis5.05
TestisGermCell4.85
TestisIntersitial4.95
TestisLeydigCell6.25
TestisSeminiferousTubule5.05
Thalamus6.05
Thymus4.6
Thyroid6.95
Tongue5.95
Tonsil5.75
Trachea4.9
TrigeminalGanglion6
Uterus4.7
UterusCorpus5.45
WholeBlood6.5
Wholebrain4.85
colon5.9
pineal_day7.04
pineal_night7.18
retina7.075
small_intestine5.6
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P147465
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.82 ± 0.4
Basal Forebrain5.83 ± 0.35
Basal Part of Pons5.67 ± 0.25
Cerebellar Cortex5.58 ± 0.26
Cerebellar Nuclei5.45 ± 0.33
Claustrum5.81 ± 0.36
Epithalamus5.59 ± 0.37
Frontal Lobe5.67 ± 0.36
Globus Pallidus5.82 ± 0.28
Hypothalamus5.62 ± 0.39
Insula5.71 ± 0.16
Limbic Lobe5.86 ± 0.31
Mesencephalon5.66 ± 0.43
Myelencephalon5.71 ± 0.36
Occipital Lobe5.62 ± 0.28
Parietal Lobe5.72 ± 0.35
Pontine Tegmentum5.61 ± 0.36
Striatum5.95 ± 0.36
Subthalamus5.57 ± 0.44
Temporal Lobe5.79 ± 0.29
Thalamus5.66 ± 0.31
White Matter6.18 ± 0.42
Mouse Brain ISH
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018