Annotation Detail for PARN
Basic Information Top
| Gene Symbol: | PARN ( DAN ) |
|---|---|
| Gene Full Name: | poly(A)-specific ribonuclease (deadenylation nuclease) |
| Band: | 16p13.12 |
| Quick Links | Entrez ID:5073; OMIM: 604212; Uniprot ID:PARN_HUMAN; ENSEMBL ID: ENSG00000140694; HGNC ID: 8609 |
| Relate to Another Database: | SFARIGene; denovo-db |
- Unigene ID: Hs.253197
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
 | |||
| embryoid body | 3 / 70761 | 42 |  |
| blastocyst | 2 / 62319 | 32 | |
| fetus | 20 / 564012 | 35 | |
| neonate | 1 / 31097 | 32 | |
| infant | 0 / 23620 | 0 | |
| juvenile | 1 / 55556 | 17 | |
| adult | 87 / 1939121 | 44 | |
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
| |||
| adrenal tumor | 1 / 12794 | 78 |  |
| bladder carcinoma | 0 / 17475 | 0 | |
| breast (mammary gland) tumor | 5 / 94178 | 53 | |
| cervical tumor | 1 / 34366 | 29 | |
| chondrosarcoma | 10 / 82823 | 120 | |
| colorectal tumor | 2 / 114246 | 17 | |
| esophageal tumor | 1 / 17290 | 57 | |
| gastrointestinal tumor | 4 / 119369 | 33 | |
| germ cell tumor | 16 / 263845 | 60 | |
| glioma | 5 / 106883 | 46 | |
| head and neck tumor | 15 / 136302 | 110 | |
| kidney tumor | 3 / 68959 | 43 | |
| leukemia | 2 / 95842 | 20 | |
| liver tumor | 7 / 96359 | 72 | |
| lung tumor | 1 / 103127 | 9 |  |
| lymphoma | 5 / 71755 | 69 | |
| non-neoplasia | 6 / 97250 | 61 | |
| normal | 129 / 3360307 | 38 | |
| ovarian tumor | 1 / 76682 | 13 | |
| pancreatic tumor | 5 / 104616 | 47 | |
| primitive neuroectodermal tumor of the CNS | 5 / 125680 | 39 | |
| prostate cancer | 6 / 102680 | 58 | |
| retinoblastoma | 4 / 46356 | 86 | |
| skin tumor | 8 / 124949 | 64 | |
| soft tissue/muscle tissue tumor | 11 / 125191 | 87 | |
| uterine tumor | 6 / 90257 | 66 | |
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
| |||
| adipose tissue | 0 / 13106 | 0 | |
| adrenal gland | 3 / 33197 | 90 | |
| ascites | 3 / 40015 | 74 | |
| bladder | 2 / 29757 | 67 | |
| blood | 5 / 123478 | 40 | |
| bone | 7 / 71655 | 97 | |
| bone marrow | 3 / 48801 | 61 | |
| brain | 47 / 1100989 | 42 | |
| cervix | 1 / 48171 | 20 | |
| connective tissue | 16 / 149255 | 107 | |
| ear | 0 / 16212 | 0 | |
| embryonic tissue | 12 / 215722 | 55 | |
| esophagus | 1 / 20209 | 49 | |
| eye | 9 / 211054 | 42 | |
| heart | 2 / 89626 | 22 | |
| intestine | 8 / 234472 | 34 | |
| kidney | 10 / 211777 | 47 | |
| larynx | 1 / 24145 | 41 | |
| liver | 10 / 207743 | 48 | |
| lung | 9 / 336974 | 26 | |
| lymph | 4 / 44270 | 90 | |
| lymph node | 3 / 91610 | 32 | |
| mammary gland | 7 / 153271 | 45 | |
| mouth | 10 / 67052 | 149 | |
| muscle | 3 / 107715 | 27 | |
| nerve | 1 / 15768 | 63 | |
| ovary | 3 / 102051 | 29 | |
| pancreas | 7 / 214812 | 32 | |
| parathyroid | 0 / 20539 | 0 | |
| pharynx | 3 / 41328 | 72 | |
| pituitary gland | 0 / 16585 | 0 | |
| placenta | 10 / 280825 | 35 | |
| prostate | 9 / 189345 | 47 | |
| salivary gland | 0 / 20155 | 0 | |
| skin | 14 / 210574 | 66 | |
| spleen | 2 / 53952 | 37 | |
| stomach | 1 / 96619 | 10 | |
| testis | 33 / 330442 | 99 | |
| thymus | 10 / 81131 | 123 | |
| thyroid | 5 / 47473 | 105 | |
| tonsil | 1 / 16999 | 58 | |
| trachea | 2 / 52413 | 38 | |
| umbilical cord | 0 / 13680 | 0 | |
| uterus | 13 / 232878 | 55 | |
| vascular | 8 / 51780 | 154 | |
- Microarray Platform: GeneAtlas U133A, gcrma
- Affymatrix Probe ID: 203905_at
| Cell line | Expression level | Expression bar |
|---|---|---|
| ||
| 721_B_lymphoblasts | 20.25 | |
| Adipocyte | 3.6 | |
| AdrenalCortex | 3.65 | |
| Adrenalgland | 3 | |
| Amygdala | 4.95 | |
| Appendix | 3.65 | |
| AtrioventricularNode | 2.75 | |
| BDCA4+_DentriticCells | 7.05 | |
| Bonemarrow | 3.5 | |
| BronchialEpithelialCells | 3.75 | |
| CD105+_Endothelial | 3.5 | |
| CD14+_Monocytes | 3.85 | |
| CD19+_BCells(neg._sel.) | 4.4 | |
| CD33+_Myeloid | 4.55 | |
| CD34+ | 5.45 | |
| CD4+_Tcells | 6.2 | |
| CD56+_NKCells | 9.35 | |
| CD71+_EarlyErythroid | 3.3 | |
| CD8+_Tcells | 3.5 | |
| CardiacMyocytes | 4.5 | |
| Caudatenucleus | 3.45 | |
| Cerebellum | 2.9 | |
| CerebellumPeduncles | 4 | |
| CiliaryGanglion | 2.5 | |
| CingulateCortex | 3.65 | |
| Colorectaladenocarcinoma | 5.3 | |
| DorsalRootGanglion | 2.7 | |
| FetalThyroid | 3.4 | |
| Fetalbrain | 3.6 | |
| Fetalliver | 3.05 | |
| Fetallung | 2.85 | |
| GlobusPallidus | 2.6 | |
| Heart | 4.5 | |
| Hypothalamus | 4.65 | |
| Kidney | 3.45 | |
| Leukemia_chronicMyelogenousK-562 | 4.25 | |
| Leukemia_promyelocytic-HL-60 | 4.5 | |
| Leukemialymphoblastic(MOLT-4) | 3.5 | |
| Liver | 4.7 | |
| Lung | 3.8 | |
| Lymphnode | 3.25 | |
| Lymphoma_burkitts(Daudi) | 7.85 | |
| Lymphoma_burkitts(Raji) | 5 | |
| MedullaOblongata | 3.3 | |
| OccipitalLobe | 3.25 | |
| OlfactoryBulb | 2.85 | |
| Ovary | 2.4 | |
| Pancreas | 2.85 | |
| PancreaticIslet | 3.8 | |
| ParietalLobe | 3.75 | |
| Pituitary | 5.35 | |
| Placenta | 3.75 | |
| Pons | 3.4 | |
| PrefrontalCortex | 5.35 | |
| Prostate | 4.2 | |
| Salivarygland | 4.8 | |
| SkeletalMuscle | 4.05 | |
| Skin | 2.8 | |
| SmoothMuscle | 4.1 | |
| Spinalcord | 5.95 | |
| SubthalamicNucleus | 3.2 | |
| SuperiorCervicalGanglion | 4.2 | |
| TemporalLobe | 3.25 | |
| Testis | 4.25 | |
| TestisGermCell | 4.45 | |
| TestisIntersitial | 3.05 | |
| TestisLeydigCell | 3.55 | |
| TestisSeminiferousTubule | 5.3 | |
| Thalamus | 3.8 | |
| Thymus | 2.9 | |
| Thyroid | 4.75 | |
| Tongue | 3.45 | |
| Tonsil | 3.4 | |
| Trachea | 3 | |
| TrigeminalGanglion | 3.5 | |
| Uterus | 2.95 | |
| UterusCorpus | 3.15 | |
| WholeBlood | 3.95 | |
| Wholebrain | 2.85 | |
| colon | 3.6 | |
| pineal_day | 5 | |
| pineal_night | 4.38 | |
| retina | 4.65 | |
| small_intestine | 3.5 | |
- Probe name: A_23_P113026
- Donor H0351.2001
- Sex: Male Age: 24 years Race/Ethnicity: African American Handedness: Left
- Tissue Receipt Date: 7/29/2009 Serology: Pass Tissue pH :6.72 Additional Medical Information :History of asthma
- Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
- Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
| Tissue | Expression(mean ± stddev) | Expression Bar |
|---|---|---|
| Amygdala | 5.12 ± 0.45 | ![](../"images/bar_3.png"){kind=small}   |
| Basal Forebrain | 5.56 ± 0.3 | |
| Basal Part of Pons | 5.62 ± 0.22 | |
| Cerebellar Cortex | 5.37 ± 0.42 | |
| Cerebellar Nuclei | 5.44 ± 0.6 | |
| Claustrum | 5.13 ± 0.68 | |
| Epithalamus | 5.59 ± 0.3 | |
| Frontal Lobe | 5.43 ± 0.4 | |
| Globus Pallidus | 5.66 ± 0.3 | |
| Hypothalamus | 5.72 ± 0.31 | |
| Insula | 5.36 ± 0.32 | |
| Limbic Lobe | 5.29 ± 0.43 | |
| Mesencephalon | 5.48 ± 0.32 | |
| Myelencephalon | 5.37 ± 0.42 | |
| Occipital Lobe | 5.08 ± 0.43 | |
| Parietal Lobe | 5.47 ± 0.34 | |
| Pontine Tegmentum | 5.39 ± 0.46 | |
| Striatum | 5.14 ± 0.41 | |
| Subthalamus | 5.55 ± 0.45 | |
| Temporal Lobe | 5.43 ± 0.37 | |
| Thalamus | 5.35 ± 0.46 | |
| White Matter | 6.31 ± 0.28 | |
Mouse Brain ISH 
| Gene Symbol | Brain Structure ID | Brain Structure Name | Express Desity/Level (Meatured by ISH) | Express Bar |
|---|---|---|---|---|
| Parn | CB | Cerebellum | 3.66 | |
| 5.06 | | |||
| Parn | CTX | Cerebral cortex | 9.93 | |
| 7.92 | | |||
| Parn | HIP | Hippocampal region | 17.64 | |
| 19.96 | | |||
| Parn | HPF | Hippocampal formation | 12.94 | |
| 13.43 | | |||
| Parn | HY | Hypothalamus | 2.62 | |
| 2.2 | | |||
| Parn | LSX | Lateral septal complex | 0.75 | |
| 0.74 | | |||
| Parn | MB | Midbrain | 3.88 | |
| 4.42 | | |||
| Parn | MY | Medulla | 14.71 | |
| 18.5 | | |||
| Parn | OLF | Olfactory bulb | 11.7 | |
| 9 | | |||
| Parn | P | Pons | 10.2 | |
| 13.14 | | |||
| Parn | PAL | Pallidum | 4.38 | |
| 4.92 | | |||
| Parn | RHP | Retrohippocampal region | 4 | |
| 3.54 | | |||
| Parn | sAMY | Striatum-like amygdalar nuclei | 5.52 | |
| 3.88 | | |||
| Parn | STR | Striatum | 2.32 | |
| 1.98 | | |||
| Parn | STRd | Striatum dorsal region | 1.91 | |
| 1.78 | | |||
| Parn | STRv | Striatum ventral region | 2.4 | |
| 1.85 | | |||
| Parn | TH | Thalamus | 4.41 | |
| 4.57 | |
| Peptide Name | Peptide Lengh | Peptide Start | Peptide End | Peptide Sequence | Source |
|---|---|---|---|---|---|
| PARN_HUMAN_0 | 0 | 0 | 0 | FIDQVVEKIEDLLQSEENK | PRIDE |
| PAp00006739 | 17 | 477 | 493 | RLNPQCIPYTLQNHYYR | Peptide Atlas |