AutismKB 2.0

Annotation Detail for IRX4


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Basic Information Top
Gene Symbol:IRX4 ( IRXA3,MGC131996 )
Gene Full Name: iroquois homeobox 4
Band: 5p15.33
Quick LinksEntrez ID:50805; OMIM: 606199; Uniprot ID:IRX4_HUMAN; ENSEMBL ID: ENSG00000113430; HGNC ID: 6129
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus1 / 5640121
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult3 / 19391211
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor10 / 26384537
glioma2 / 10688318
head and neck tumor1 / 1363027
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal2 / 33603070 
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer1 / 1026809
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain2 / 11009891
cervix0 / 481710 
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye1 / 2110544
heart0 / 896260 
intestine0 / 2344720 
kidney0 / 2117770 
larynx1 / 2414541
liver0 / 2077430 
lung1 / 3369742
lymph0 / 442700 
lymph node0 / 916100 
mammary gland0 / 1532710 
mouth0 / 670520 
muscle0 / 1077150 
nerve0 / 157680 
ovary0 / 1020510 
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta7 / 28082524
prostate1 / 1893455
salivary gland0 / 201550 
skin0 / 2105740 
spleen0 / 539520 
stomach0 / 966190 
testis0 / 3304420 
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus0 / 2328780 
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 220225_at
Cell line Expression level Expression bar
721_B_lymphoblasts8.7
Adipocyte8.55
AdrenalCortex14.75
Adrenalgland7.7
Amygdala8.45
Appendix8.6
AtrioventricularNode10.5
BDCA4+_DentriticCells8.35
Bonemarrow8.65
BronchialEpithelialCells8.45
CD105+_Endothelial8.65
CD14+_Monocytes9.15
CD19+_BCells(neg._sel.)9.1
CD33+_Myeloid10.3
CD34+10.8
CD4+_Tcells9.25
CD56+_NKCells9.5
CD71+_EarlyErythroid8.15
CD8+_Tcells7
CardiacMyocytes10.9
Caudatenucleus7.7
Cerebellum7.05
CerebellumPeduncles10.3
CiliaryGanglion6.65
CingulateCortex9.25
Colorectaladenocarcinoma8.4
DorsalRootGanglion9.3
FetalThyroid8.4
Fetalbrain8.5
Fetalliver7.5
Fetallung7
GlobusPallidus6.4
Heart14.4
Hypothalamus8.7
Kidney7.75
Leukemia_chronicMyelogenousK-5627.85
Leukemia_promyelocytic-HL-607.65
Leukemialymphoblastic(MOLT-4)7
Liver11.35
Lung9.4
Lymphnode7.35
Lymphoma_burkitts(Daudi)11.1
Lymphoma_burkitts(Raji)12.15
MedullaOblongata7.8
OccipitalLobe7.75
OlfactoryBulb6.8
Ovary7.8
Pancreas7.5
PancreaticIslet9.2
ParietalLobe14.1
Pituitary10.05
Placenta8.8
Pons8.25
PrefrontalCortex10
Prostate12.05
Salivarygland7
SkeletalMuscle11.95
Skin16.7
SmoothMuscle9.7
Spinalcord9.25
SubthalamicNucleus8.25
SuperiorCervicalGanglion10.1
TemporalLobe7.95
Testis7.4
TestisGermCell7.05
TestisIntersitial7.3
TestisLeydigCell8.6
TestisSeminiferousTubule8.85
Thalamus8.95
Thymus6.75
Thyroid10.7
Tongue10
Tonsil8.4
Trachea7.2
TrigeminalGanglion8.8
Uterus7
UterusCorpus8.05
WholeBlood9.4
Wholebrain7.2
colon8.65
pineal_day10.44
pineal_night10.14
retina10.45
small_intestine8.3
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P20795
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala8.28 ± 0.77
Basal Forebrain8 ± 0.24
Basal Part of Pons7.99 ± 0.46
Cerebellar Cortex7.6 ± 0.49
Cerebellar Nuclei8.29 ± 0.38
Claustrum8.44 ± 0.64
Epithalamus7.46 ± 0.59
Frontal Lobe7.97 ± 0.53
Globus Pallidus8.46 ± 0.45
Hypothalamus7.82 ± 0.37
Insula7.84 ± 0.5
Limbic Lobe8.07 ± 0.57
Mesencephalon8.13 ± 0.47
Myelencephalon8 ± 0.57
Occipital Lobe7.88 ± 0.63
Parietal Lobe7.88 ± 0.5
Pontine Tegmentum7.77 ± 0.4
Striatum8.15 ± 0.51
Subthalamus7.98 ± 0.25
Temporal Lobe7.82 ± 0.52
Thalamus8.01 ± 0.44
White Matter8.01 ± 0.27
Mouse Brain ISH
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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