AutismKB 2.0

Annotation Detail for TAS2R8


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Basic Information Top
Gene Symbol:TAS2R8 ( T2R8,TRB5 )
Gene Full Name: taste receptor, type 2, member 8
Band: 12p13.2
Quick LinksEntrez ID:50836; OMIM: 604794; Uniprot ID:TA2R8_HUMAN; ENSEMBL ID: ENSG00000121314; HGNC ID: 14915
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Microarray in BioGPS Top
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  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 221398_at
Cell line Expression level Expression bar
721_B_lymphoblasts4.7
Adipocyte3.7
AdrenalCortex4
Adrenalgland3.2
Amygdala3.9
Appendix4.05
AtrioventricularNode3.05
BDCA4+_DentriticCells4.15
Bonemarrow3.8
BronchialEpithelialCells3.75
CD105+_Endothelial3.8
CD14+_Monocytes4.05
CD19+_BCells(neg._sel.)4.05
CD33+_Myeloid4.85
CD34+4.8
CD4+_Tcells4.1
CD56+_NKCells4.5
CD71+_EarlyErythroid3.55
CD8+_Tcells3.65
CardiacMyocytes4.9
Caudatenucleus3.35
Cerebellum3.05
CerebellumPeduncles4.3
CiliaryGanglion2.7
CingulateCortex3.85
Colorectaladenocarcinoma3.8
DorsalRootGanglion2.95
FetalThyroid3.65
Fetalbrain3.75
Fetalliver3.3
Fetallung3.1
GlobusPallidus2.8
Heart4.85
Hypothalamus4.15
Kidney3.05
Leukemia_chronicMyelogenousK-5623.4
Leukemia_promyelocytic-HL-603.3
Leukemialymphoblastic(MOLT-4)3.05
Liver5.05
Lung4.1
Lymphnode3.25
Lymphoma_burkitts(Daudi)4.85
Lymphoma_burkitts(Raji)5.35
MedullaOblongata3.45
OccipitalLobe3.4
OlfactoryBulb2.95
Ovary2.5
Pancreas3.05
PancreaticIslet4.05
ParietalLobe4.05
Pituitary4.45
Placenta3.9
Pons3.65
PrefrontalCortex4.65
Prostate4.4
Salivarygland3
SkeletalMuscle4.45
Skin2.9
SmoothMuscle4.25
Spinalcord4.05
SubthalamicNucleus3.45
SuperiorCervicalGanglion4.5
TemporalLobe3.5
Testis3.2
TestisGermCell3.15
TestisIntersitial3.15
TestisLeydigCell3.75
TestisSeminiferousTubule3.25
Thalamus3.85
Thymus3
Thyroid4.7
Tongue3.7
Tonsil3.7
Trachea3.2
TrigeminalGanglion3.8
Uterus3.1
UterusCorpus3.6
WholeBlood4.1
Wholebrain3.15
colon3.8
pineal_day4.72
pineal_night4.64
retina4.525
small_intestine3.6
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P48022
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.28 ± 1.06
Basal Forebrain1.98 ± 0.17
Basal Part of Pons1.62 ± 0.35
Cerebellar Cortex1.79 ± 0.68
Cerebellar Nuclei2.17 ± 0.7
Claustrum2.7 ± 0.87
Epithalamus1.78 ± 0.92
Frontal Lobe1.76 ± 0.7
Globus Pallidus2.35 ± 0.36
Hypothalamus1.88 ± 0.49
Insula1.7 ± 0.51
Limbic Lobe1.95 ± 0.68
Mesencephalon2.15 ± 0.71
Myelencephalon1.93 ± 0.65
Occipital Lobe2.15 ± 0.66
Parietal Lobe1.97 ± 0.7
Pontine Tegmentum2.03 ± 0.73
Striatum2.05 ± 0.49
Subthalamus2.05 ± 0.71
Temporal Lobe1.87 ± 0.68
Thalamus1.89 ± 0.58
White Matter2.44 ± 0.26
Mouse Brain ISH
Peptide Top

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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018