AutismKB 2.0

Annotation Detail for PBX2


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Basic Information Top
Gene Symbol:PBX2 ( G17,HOX12,PBX2MHC )
Gene Full Name: pre-B-cell leukemia homeobox 2
Band: 6p21.32
Quick LinksEntrez ID:5089; OMIM: 176311; Uniprot ID:PBX2_HUMAN; ENSEMBL ID: ENSG00000204304; HGNC ID: 8633
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst3 / 6231948
fetus10 / 56401217
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult93 / 193912147
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor4 / 9417842
cervical tumor0 / 343660 
chondrosarcoma3 / 8282336
colorectal tumor7 / 11424661
esophageal tumor0 / 172900 
gastrointestinal tumor1 / 1193698
germ cell tumor6 / 26384522
glioma1 / 1068839
head and neck tumor5 / 13630236
kidney tumor3 / 6895943
leukemia4 / 9584241
liver tumor0 / 963590 
lung tumor9 / 10312787
lymphoma4 / 7175555
non-neoplasia3 / 9725030
normal84 / 336030724
ovarian tumor7 / 7668291
pancreatic tumor2 / 10461619
primitive neuroectodermal tumor of the CNS3 / 12568023
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor3 / 12494924
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor2 / 9025722
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland0 / 331970 
ascites1 / 4001524
bladder0 / 297570 
blood4 / 12347832
bone5 / 7165569
bone marrow1 / 4880120
brain13 / 110098911
cervix0 / 481710 
connective tissue1 / 1492556
ear0 / 162120 
embryonic tissue8 / 21572237
esophagus0 / 202090 
eye8 / 21105437
heart0 / 896260 
intestine8 / 23447234
kidney7 / 21177733
larynx2 / 2414582
liver1 / 2077434
lung16 / 33697447
lymph3 / 4427067
lymph node4 / 9161043
mammary gland5 / 15327132
mouth0 / 670520 
muscle0 / 1077150 
nerve0 / 157680 
ovary8 / 10205178
pancreas9 / 21481241
parathyroid2 / 2053997
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta20 / 28082571
prostate0 / 1893450 
salivary gland0 / 201550 
skin8 / 21057437
spleen2 / 5395237
stomach0 / 966190 
testis2 / 3304426
thymus2 / 8113124
thyroid5 / 47473105
tonsil1 / 1699958
trachea0 / 524130 
umbilical cord0 / 136800 
uterus5 / 23287821
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 202875_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts41.85
Adipocyte17.2
AdrenalCortex45.9
Adrenalgland21.25
Amygdala9.25
Appendix17.6
AtrioventricularNode33.05
BDCA4+_DentriticCells96.35
Bonemarrow17.65
BronchialEpithelialCells13.7
CD105+_Endothelial36.95
CD14+_Monocytes21.35
CD19+_BCells(neg._sel.)38.95
CD33+_Myeloid27.7
CD34+28.15
CD4+_Tcells27.55
CD56+_NKCells31.9
CD71+_EarlyErythroid28.55
CD8+_Tcells17.15
CardiacMyocytes20.55
Caudatenucleus15.95
Cerebellum14.1
CerebellumPeduncles20.25
CiliaryGanglion12.8
CingulateCortex32.75
Colorectaladenocarcinoma13.05
DorsalRootGanglion13.8
FetalThyroid21.6
Fetalbrain17.25
Fetalliver18.6
Fetallung25.9
GlobusPallidus21.85
Heart23.1
Hypothalamus18.55
Kidney16.35
Leukemia_chronicMyelogenousK-56215.8
Leukemia_promyelocytic-HL-6015.75
Leukemialymphoblastic(MOLT-4)14.65
Liver22.65
Lung24.9
Lymphnode14.75
Lymphoma_burkitts(Daudi)22.35
Lymphoma_burkitts(Raji)24.25
MedullaOblongata22
OccipitalLobe15.7
OlfactoryBulb14.7
Ovary19.3
Pancreas23.05
PancreaticIslet18.25
ParietalLobe18.45
Pituitary22.05
Placenta33.8
Pons53.8
PrefrontalCortex21.2
Prostate19.45
Salivarygland14.1
SkeletalMuscle26.15
Skin13.9
SmoothMuscle15.75
Spinalcord16.95
SubthalamicNucleus38.15
SuperiorCervicalGanglion24.6
TemporalLobe20.9
Testis14.5
TestisGermCell17.7
TestisIntersitial13.7
TestisLeydigCell19.75
TestisSeminiferousTubule20.5
Thalamus36.25
Thymus16
Thyroid15.9
Tongue18.85
Tonsil17.25
Trachea18.85
TrigeminalGanglion18.05
Uterus12.4
UterusCorpus16.05
WholeBlood180.4
Wholebrain11.2
colon14.25
pineal_day29.14
pineal_night24.44
retina19.775
small_intestine16.3
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_32_P141664
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.52 ± 0.24
Basal Forebrain7.31 ± 0.13
Basal Part of Pons7.2 ± 0.25
Cerebellar Cortex7.24 ± 0.28
Cerebellar Nuclei7.13 ± 0.28
Claustrum7.45 ± 0.41
Epithalamus7.26 ± 0.43
Frontal Lobe7.23 ± 0.3
Globus Pallidus7.35 ± 0.22
Hypothalamus7 ± 0.36
Insula7.37 ± 0.31
Limbic Lobe7.52 ± 0.26
Mesencephalon7.24 ± 0.26
Myelencephalon7.38 ± 0.31
Occipital Lobe7.51 ± 0.25
Parietal Lobe7.37 ± 0.27
Pontine Tegmentum7.3 ± 0.31
Striatum7.63 ± 0.31
Subthalamus6.96 ± 0.07
Temporal Lobe7.41 ± 0.25
Thalamus7.34 ± 0.24
White Matter7.84 ± 0.17
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Pbx2CBCerebellum90.33
100
Pbx2CTXCerebral cortex100
100
Pbx2HIPHippocampal region99.25
100
Pbx2HPFHippocampal formation100
100
Pbx2HYHypothalamus38.75
35.18
Pbx2LSXLateral septal complex65.74
51.27
Pbx2MBMidbrain61.36
65.29
Pbx2MYMedulla59.55
75.45
Pbx2OLFOlfactory bulb100
100
Pbx2PPons42.44
52.23
Pbx2PALPallidum57.52
57.24
Pbx2RHPRetrohippocampal region100
100
Pbx2sAMYStriatum-like amygdalar nuclei88.01
81.98
Pbx2STRStriatum100
100
Pbx2STRdStriatum dorsal region100
100
Pbx2STRvStriatum ventral region100
93.83
Pbx2THThalamus60.21
60.42
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00009474 15 284 298 CGITVSQVSNWFGNK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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