AutismKB 2.0

Annotation Detail for PC


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:PC ( PCB )
Gene Full Name: pyruvate carboxylase
Band: 11q13.2
Quick LinksEntrez ID:5091; OMIM: 608786; Uniprot ID:PYC_HUMAN; ENSEMBL ID: ENSG00000173599; HGNC ID: 8636
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body3 / 7076142
blastocyst2 / 6231932
fetus5 / 5640128
neonate0 / 310970 
infant0 / 236200 
juvenile1 / 5555617
adult30 / 193912115
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor3 / 9417831
cervical tumor3 / 3436687
chondrosarcoma5 / 8282360
colorectal tumor1 / 1142468
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor4 / 26384515
glioma5 / 10688346
head and neck tumor0 / 1363020 
kidney tumor0 / 689590 
leukemia3 / 9584231
liver tumor2 / 9635920
lung tumor8 / 10312777
lymphoma0 / 717550 
non-neoplasia3 / 9725030
normal50 / 336030714
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS3 / 12568023
prostate cancer1 / 1026809
retinoblastoma4 / 4635686
skin tumor4 / 12494932
soft tissue/muscle tissue tumor3 / 12519123
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue2 / 13106152
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood3 / 12347824
bone5 / 7165569
bone marrow1 / 4880120
brain19 / 110098917
cervix5 / 48171103
connective tissue1 / 1492556
ear0 / 162120 
embryonic tissue5 / 21572223
esophagus0 / 202090 
eye12 / 21105456
heart0 / 896260 
intestine3 / 23447212
kidney4 / 21177718
larynx0 / 241450 
liver4 / 20774319
lung15 / 33697444
lymph0 / 442700 
lymph node0 / 916100 
mammary gland3 / 15327119
mouth0 / 670520 
muscle0 / 1077150 
nerve1 / 1576863
ovary0 / 1020510 
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate2 / 18934510
salivary gland0 / 201550 
skin5 / 21057423
spleen0 / 539520 
stomach0 / 966190 
testis4 / 33044212
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus4 / 23287817
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 204476_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts9.8
Adipocyte29.55
AdrenalCortex10.4
Adrenalgland10.4
Amygdala19.15
Appendix9.9
AtrioventricularNode7.35
BDCA4+_DentriticCells8.2
Bonemarrow9.2
BronchialEpithelialCells17.75
CD105+_Endothelial10.1
CD14+_Monocytes9.75
CD19+_BCells(neg._sel.)8.45
CD33+_Myeloid10.15
CD34+7.45
CD4+_Tcells8.05
CD56+_NKCells8.95
CD71+_EarlyErythroid13.65
CD8+_Tcells6.05
CardiacMyocytes10.9
Caudatenucleus22.65
Cerebellum19.4
CerebellumPeduncles13.7
CiliaryGanglion6.8
CingulateCortex14.9
Colorectaladenocarcinoma10.35
DorsalRootGanglion7.65
FetalThyroid8.8
Fetalbrain10.05
Fetalliver24.55
Fetallung9.05
GlobusPallidus8.15
Heart10.95
Hypothalamus21.25
Kidney21.05
Leukemia_chronicMyelogenousK-5628.2
Leukemia_promyelocytic-HL-608.35
Leukemialymphoblastic(MOLT-4)8.8
Liver60.6
Lung11.45
Lymphnode8.8
Lymphoma_burkitts(Daudi)11.15
Lymphoma_burkitts(Raji)13.05
MedullaOblongata14.1
OccipitalLobe9.35
OlfactoryBulb16.1
Ovary6.6
Pancreas6.55
PancreaticIslet9.95
ParietalLobe11.25
Pituitary11.9
Placenta10.7
Pons15.3
PrefrontalCortex28.95
Prostate20.2
Salivarygland7.05
SkeletalMuscle11.35
Skin7.45
SmoothMuscle11.1
Spinalcord50.9
SubthalamicNucleus12.75
SuperiorCervicalGanglion11.05
TemporalLobe13.5
Testis12.55
TestisGermCell10.6
TestisIntersitial9.2
TestisLeydigCell10
TestisSeminiferousTubule9
Thalamus19.8
Thymus8
Thyroid13.1
Tongue9.6
Tonsil9.8
Trachea9.05
TrigeminalGanglion9.45
Uterus7.5
UterusCorpus7.95
WholeBlood11.4
Wholebrain20.95
colon5.2
pineal_day11.5
pineal_night11.96
retina17.725
small_intestine4.35
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_9170_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.95 ± 0.8
Basal Forebrain5.32 ± 0.42
Basal Part of Pons5.8 ± 0.48
Cerebellar Cortex5.55 ± 0.72
Cerebellar Nuclei4.79 ± 0.41
Claustrum4.33 ± 0.87
Epithalamus5.74 ± 0.78
Frontal Lobe5.51 ± 0.66
Globus Pallidus5.18 ± 0.22
Hypothalamus5.31 ± 0.7
Insula5.47 ± 0.44
Limbic Lobe5.01 ± 0.74
Mesencephalon5.29 ± 0.56
Myelencephalon5.35 ± 0.61
Occipital Lobe5.04 ± 0.59
Parietal Lobe5.36 ± 0.56
Pontine Tegmentum5.13 ± 0.65
Striatum5.17 ± 0.54
Subthalamus5.37 ± 0.7
Temporal Lobe5.38 ± 0.49
Thalamus5.56 ± 0.54
White Matter4.57 ± 0.44
Mouse Brain ISH
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00003370 20 244 263 HIEVQILGDQYGNILHLYER Peptide Atlas
PYC_HUMAN_559 13 559 571 NHPGLLLMDTTFR PRIDE
PYC_HUMAN_78 11 78 88 QKADEAYLIGR PRIDE
PYC_HUMAN_913 16 913 928 IVGDLAQFMVQNGLSR PRIDE
PYC_HUMAN_978 20 978 997 PGASLPPLDLQALEKELVDR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved