AutismKB 2.0

Annotation Detail for PDE11A


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:PDE11A ( FLJ23693,MGC133355,MGC133356,PPNAD2 )
Gene Full Name: phosphodiesterase 11A
Band: 2q31.2
Quick LinksEntrez ID:50940; OMIM: 604961; Uniprot ID:PDE11_HUMAN; ENSEMBL ID: ENSG00000128655; HGNC ID: 8773
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus1 / 5640121
neonate0 / 310970 
infant0 / 236200 
juvenile1 / 5555617
adult7 / 19391213
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor5 / 26384518
glioma0 / 1068830 
head and neck tumor3 / 13630222
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia3 / 9725030
normal18 / 33603075
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain18 / 110098916
cervix0 / 481710 
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye0 / 2110540 
heart0 / 896260 
intestine0 / 2344720 
kidney0 / 2117770 
larynx2 / 2414582
liver0 / 2077430 
lung0 / 3369740 
lymph0 / 442700 
lymph node0 / 916100 
mammary gland0 / 1532710 
mouth1 / 6705214
muscle1 / 1077159
nerve1 / 1576863
ovary0 / 1020510 
pancreas0 / 2148120 
parathyroid1 / 2053948
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate1 / 1893455
salivary gland0 / 201550 
skin0 / 2105740 
spleen0 / 539520 
stomach0 / 966190 
testis4 / 33044212
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus0 / 2328780 
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 221110_x_at
Cell line Expression level Expression bar
721_B_lymphoblasts8.15
Adipocyte6.65
AdrenalCortex7.05
Adrenalgland5.55
Amygdala7.2
Appendix7.75
AtrioventricularNode5.1
BDCA4+_DentriticCells5.75
Bonemarrow6.75
BronchialEpithelialCells6.4
CD105+_Endothelial6.7
CD14+_Monocytes6.95
CD19+_BCells(neg._sel.)7
CD33+_Myeloid8.15
CD34+7.25
CD4+_Tcells6.5
CD56+_NKCells8.1
CD71+_EarlyErythroid6.25
CD8+_Tcells6.45
CardiacMyocytes8.3
Caudatenucleus6
Cerebellum6.75
CerebellumPeduncles7.5
CiliaryGanglion4.65
CingulateCortex8.05
Colorectaladenocarcinoma6.75
DorsalRootGanglion5
FetalThyroid6.5
Fetalbrain6.75
Fetalliver5.75
Fetallung5.45
GlobusPallidus5.15
Heart8.9
Hypothalamus7.4
Kidney5.35
Leukemia_chronicMyelogenousK-5625.85
Leukemia_promyelocytic-HL-605.85
Leukemialymphoblastic(MOLT-4)5.35
Liver10.4
Lung7.25
Lymphnode5.7
Lymphoma_burkitts(Daudi)8.5
Lymphoma_burkitts(Raji)9.3
MedullaOblongata6.25
OccipitalLobe6.1
OlfactoryBulb5.25
Ovary4.35
Pancreas5.6
PancreaticIslet7.45
ParietalLobe7.95
Pituitary7.85
Placenta7.05
Pons6.35
PrefrontalCortex8.55
Prostate7.95
Salivarygland5.45
SkeletalMuscle8.25
Skin5
SmoothMuscle6.7
Spinalcord7.3
SubthalamicNucleus6
SuperiorCervicalGanglion7.55
TemporalLobe6.05
Testis7.85
TestisGermCell5.75
TestisIntersitial5.65
TestisLeydigCell6.55
TestisSeminiferousTubule5.8
Thalamus6.8
Thymus5.2
Thyroid8.15
Tongue7
Tonsil6.5
Trachea5.75
TrigeminalGanglion6.55
Uterus5.55
UterusCorpus6.15
WholeBlood6.7
Wholebrain5.8
colon6.75
pineal_day8.42
pineal_night8.24
retina8.225
small_intestine6.6
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P394367
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.44 ± 0.93
Basal Forebrain2.31 ± 0.68
Basal Part of Pons2.26 ± 0.7
Cerebellar Cortex1.81 ± 0.62
Cerebellar Nuclei2.69 ± 0.85
Claustrum2.74 ± 0.91
Epithalamus2.3 ± 1.18
Frontal Lobe1.95 ± 0.79
Globus Pallidus3.73 ± 0.68
Hypothalamus2.52 ± 0.74
Insula1.9 ± 0.51
Limbic Lobe2.06 ± 0.71
Mesencephalon2.61 ± 0.77
Myelencephalon2.19 ± 0.79
Occipital Lobe2.22 ± 0.95
Parietal Lobe2.29 ± 0.95
Pontine Tegmentum2.21 ± 0.91
Striatum2.26 ± 0.69
Subthalamus2.65 ± 0.68
Temporal Lobe2.03 ± 0.71
Thalamus2.06 ± 0.67
White Matter4.66 ± 0.87
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Pde11aCBCerebellum1.15
0.93
Pde11aCTXCerebral cortex4.85
2.21
Pde11aHIPHippocampal region8.77
7.89
Pde11aHPFHippocampal formation10.93
7.11
Pde11aHYHypothalamus2.84
1.02
Pde11aLSXLateral septal complex0.62
0.39
Pde11aMBMidbrain0.92
0.43
Pde11aMYMedulla1.67
0.74
Pde11aOLFOlfactory bulb9.22
4.5
Pde11aPPons1.57
0.75
Pde11aPALPallidum3.87
1.9
Pde11aRHPRetrohippocampal region12.91
6.11
Pde11asAMYStriatum-like amygdalar nuclei5.99
2.48
Pde11aSTRStriatum2.07
1.21
Pde11aSTRdStriatum dorsal region0.67
0.42
Pde11aSTRvStriatum ventral region4.64
3.06
Pde11aTHThalamus1.43
1.22
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved