AutismKB 2.0

Annotation Detail for LAP3


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Basic Information Top
Gene Symbol:LAP3 ( LAP,LAPEP,PEPS )
Gene Full Name: leucine aminopeptidase 3
Band: 4p15.32
Quick LinksEntrez ID:51056; OMIM: 170250; Uniprot ID:AMPL_HUMAN; ENSEMBL ID: ENSG00000002549; HGNC ID: 18449
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body8 / 70761113
blastocyst6 / 6231996
fetus39 / 56401269
neonate6 / 31097192
infant14 / 23620592
juvenile12 / 55556215
adult203 / 1939121104
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma1 / 1747557
breast (mammary gland) tumor12 / 94178127
cervical tumor8 / 34366232
chondrosarcoma12 / 82823144
colorectal tumor10 / 11424687
esophageal tumor16 / 17290925
gastrointestinal tumor9 / 11936975
germ cell tumor26 / 26384598
glioma11 / 106883102
head and neck tumor5 / 13630236
kidney tumor8 / 68959116
leukemia5 / 9584252
liver tumor21 / 96359217
lung tumor6 / 10312758
lymphoma9 / 71755125
non-neoplasia38 / 97250390
normal489 / 3360307145
ovarian tumor6 / 7668278
pancreatic tumor5 / 10461647
primitive neuroectodermal tumor of the CNS37 / 125680294
prostate cancer5 / 10268048
retinoblastoma12 / 46356258
skin tumor13 / 124949104
soft tissue/muscle tissue tumor8 / 12519163
uterine tumor11 / 90257121
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue2 / 13106152
adrenal gland9 / 33197271
ascites2 / 4001549
bladder21 / 29757705
blood22 / 123478178
bone9 / 71655125
bone marrow5 / 48801102
brain169 / 1100989153
cervix17 / 48171352
connective tissue47 / 149255314
ear1 / 1621261
embryonic tissue23 / 215722106
esophagus16 / 20209791
eye23 / 211054108
heart23 / 89626256
intestine27 / 234472115
kidney40 / 211777188
larynx1 / 2414541
liver33 / 207743158
lung32 / 33697494
lymph5 / 44270112
lymph node5 / 9161054
mammary gland16 / 153271104
mouth1 / 6705214
muscle8 / 10771574
nerve0 / 157680 
ovary6 / 10205158
pancreas11 / 21481251
parathyroid0 / 205390 
pharynx19 / 41328459
pituitary gland0 / 165850 
placenta31 / 280825110
prostate14 / 18934573
salivary gland0 / 201550 
skin33 / 210574156
spleen20 / 53952370
stomach14 / 96619144
testis51 / 330442154
thymus20 / 81131246
thyroid3 / 4747363
tonsil1 / 1699958
trachea5 / 5241395
umbilical cord4 / 13680292
uterus65 / 232878279
vascular9 / 51780173
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 217933_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts1424.65
Adipocyte209.75
AdrenalCortex33.45
Adrenalgland126.1
Amygdala193.1
Appendix31.2
AtrioventricularNode36.55
BDCA4+_DentriticCells1270.75
Bonemarrow51.6
BronchialEpithelialCells187.85
CD105+_Endothelial314.75
CD14+_Monocytes723.7
CD19+_BCells(neg._sel.)107.8
CD33+_Myeloid435.65
CD34+357.25
CD4+_Tcells113.5
CD56+_NKCells203.7
CD71+_EarlyErythroid66.4
CD8+_Tcells126.05
CardiacMyocytes114.85
Caudatenucleus121.85
Cerebellum25.3
CerebellumPeduncles36.65
CiliaryGanglion52.85
CingulateCortex31.65
Colorectaladenocarcinoma129.4
DorsalRootGanglion54.5
FetalThyroid93.7
Fetalbrain81.6
Fetalliver121.45
Fetallung273.1
GlobusPallidus48.3
Heart84.85
Hypothalamus262.7
Kidney153.05
Leukemia_chronicMyelogenousK-562115.5
Leukemia_promyelocytic-HL-60246.7
Leukemialymphoblastic(MOLT-4)176.05
Liver203
Lung269.25
Lymphnode665.7
Lymphoma_burkitts(Daudi)693.8
Lymphoma_burkitts(Raji)173.3
MedullaOblongata64.05
OccipitalLobe126.6
OlfactoryBulb102.15
Ovary54.6
Pancreas81.55
PancreaticIslet178.05
ParietalLobe78.45
Pituitary127.3
Placenta223.65
Pons20.4
PrefrontalCortex150.9
Prostate114.3
Salivarygland177.8
SkeletalMuscle43.15
Skin23.45
SmoothMuscle292.4
Spinalcord290.25
SubthalamicNucleus42.6
SuperiorCervicalGanglion26.4
TemporalLobe53.4
Testis254.45
TestisGermCell303.4
TestisIntersitial207.9
TestisLeydigCell176.8
TestisSeminiferousTubule106.2
Thalamus159.35
Thymus180.75
Thyroid252.15
Tongue67.75
Tonsil462.65
Trachea173.35
TrigeminalGanglion27.2
Uterus80.95
UterusCorpus18.1
WholeBlood279.3
Wholebrain78.1
colon397.3
pineal_day103
pineal_night110.56
retina216.85
small_intestine492.55
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_8124_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.27 ± 0.42
Basal Forebrain7.19 ± 0.21
Basal Part of Pons7.01 ± 0.22
Cerebellar Cortex7.03 ± 0.2
Cerebellar Nuclei7.83 ± 0.28
Claustrum6.94 ± 0.31
Epithalamus7.56 ± 0.33
Frontal Lobe7.32 ± 0.39
Globus Pallidus8.29 ± 0.24
Hypothalamus7.11 ± 0.72
Insula7.22 ± 0.25
Limbic Lobe7.21 ± 0.32
Mesencephalon7.4 ± 0.34
Myelencephalon7.41 ± 0.41
Occipital Lobe7.47 ± 0.3
Parietal Lobe7.26 ± 0.31
Pontine Tegmentum7.49 ± 0.38
Striatum7.77 ± 0.38
Subthalamus7.55 ± 0.01
Temporal Lobe7.25 ± 0.35
Thalamus7.6 ± 0.3
White Matter8.25 ± 0.37
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Lap3CBCerebellum8.47
11.27
Lap3CTXCerebral cortex2.59
2.41
Lap3HIPHippocampal region4.68
4.37
Lap3HPFHippocampal formation4.17
3.7
Lap3HYHypothalamus8.58
6.95
Lap3LSXLateral septal complex3.77
6.19
Lap3MBMidbrain3.59
3.54
Lap3MYMedulla8.01
9.29
Lap3OLFOlfactory bulb19.31
15.78
Lap3PPons11.44
12.89
Lap3PALPallidum6.53
5.69
Lap3RHPRetrohippocampal region2.32
2.05
Lap3sAMYStriatum-like amygdalar nuclei6.09
4.53
Lap3STRStriatum4.97
4.13
Lap3STRdStriatum dorsal region3.31
2.74
Lap3STRvStriatum ventral region11.2
7.88
Lap3THThalamus2.55
2.09
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
AMPL_HUMAN_0 0 0 0 GSPNANEPPLVFVGK PRIDE
AMPL_HUMAN_0 0 0 0 GVLFASGQNLAR PRIDE
AMPL_HUMAN_0 0 0 0 TFYGLHQDFPSVVLVGLGK PRIDE
AMPL_HUMAN_103 19 103 121 KAAGIDEQENWHEGKENIR PRIDE
AMPL_HUMAN_105 14 105 118 AAGIDEQENWHEGK PRIDE
AMPL_HUMAN_123 8 123 130 AAVAAGCR PRIDE
AMPL_HUMAN_169 14 169 182 QLMETPANEMTPTR PRIDE
AMPL_HUMAN_188 12 188 199 GVLFASGQNLAR PRIDE
AMPL_HUMAN_200 14 200 213 QLMETPANEMTPTR PRIDE
AMPL_HUMAN_201 14 201 214 QLMETPANEMTPTR PRIDE
AMPL_HUMAN_321 21 321 341 LNLPINIIGLAPLCENMPSGK PRIDE
AMPL_HUMAN_343 9 343 351 ANKPGDVVR PRIDE
AMPL_HUMAN_356 12 356 367 TIQVDNTDAEGR PRIDE
AMPL_HUMAN_357 12 357 368 TIQVDNTDAEGR PRIDE
AMPL_HUMAN_368 16 368 383 LILADALCYAHTFNPK PRIDE
AMPL_HUMAN_369 16 369 384 LILADALCYAHTFNPK PRIDE
AMPL_HUMAN_400 9 400 408 MPLFEHYTR PRIDE
AMPL_HUMAN_417 11 417 427 LFEASIETGDR PRIDE
AMPL_HUMAN_46 21 46 66 EDDVPQFTSAGENFDKLLAGK PRIDE
AMPL_HUMAN_498 8 498 505 GMTGRPTR PRIDE
AMPL_HUMAN_505 8 505 512 TLIEFLLR PRIDE
AMPL_HUMAN_506 8 506 513 TLIEFLLR PRIDE
AMPL_HUMAN_84 19 84 102 TFYGLHQDFPSVVLVGLGK PRIDE
AMPL_HUMAN_85 19 85 103 TFYGLHQDFPSVVLVGLGK PRIDE
PAp00000262 18 304 321 ADMGGAATICSAIVSAAK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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