AutismKB 2.0

Annotation Detail for KLHL5


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Basic Information Top
Gene Symbol:KLHL5 ( DKFZp586M1418,FLJ11313 )
Gene Full Name: kelch-like 5 (Drosophila)
Band: 4p14
Quick LinksEntrez ID:51088; OMIM: 608064; Uniprot ID:KLHL5_HUMAN; ENSEMBL ID: ENSG00000109790; HGNC ID: 6356
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body5 / 7076170
blastocyst0 / 623190 
fetus19 / 56401233
neonate0 / 310970 
infant0 / 236200 
juvenile2 / 5555635
adult115 / 193912159
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor1 / 9417810
cervical tumor2 / 3436658
chondrosarcoma5 / 8282360
colorectal tumor1 / 1142468
esophageal tumor1 / 1729057
gastrointestinal tumor3 / 11936925
germ cell tumor5 / 26384518
glioma8 / 10688374
head and neck tumor9 / 13630266
kidney tumor7 / 68959101
leukemia1 / 9584210
liver tumor5 / 9635951
lung tumor2 / 10312719
lymphoma2 / 7175527
non-neoplasia8 / 9725082
normal173 / 336030751
ovarian tumor3 / 7668239
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS1 / 1256807
prostate cancer25 / 102680243
retinoblastoma0 / 463560 
skin tumor2 / 12494916
soft tissue/muscle tissue tumor7 / 12519155
uterine tumor2 / 9025722
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites1 / 4001524
bladder0 / 297570 
blood2 / 12347816
bone4 / 7165555
bone marrow1 / 4880120
brain63 / 110098957
cervix2 / 4817141
connective tissue7 / 14925546
ear0 / 162120 
embryonic tissue8 / 21572237
esophagus1 / 2020949
eye3 / 21105414
heart0 / 896260 
intestine4 / 23447217
kidney14 / 21177766
larynx0 / 241450 
liver9 / 20774343
lung8 / 33697423
lymph2 / 4427045
lymph node19 / 91610207
mammary gland17 / 153271110
mouth1 / 6705214
muscle2 / 10771518
nerve1 / 1576863
ovary3 / 10205129
pancreas7 / 21481232
parathyroid0 / 205390 
pharynx7 / 41328169
pituitary gland0 / 165850 
placenta24 / 28082585
prostate30 / 189345158
salivary gland1 / 2015549
skin7 / 21057433
spleen3 / 5395255
stomach1 / 9661910
testis8 / 33044224
thymus1 / 8113112
thyroid1 / 4747321
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord0 / 136800 
uterus12 / 23287851
vascular3 / 5178057
Microarray in BioGPS Top
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P17710
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.41 ± 0.2
Basal Forebrain7.55 ± 0.43
Basal Part of Pons7.12 ± 0.21
Cerebellar Cortex7.56 ± 0.28
Cerebellar Nuclei7.42 ± 0.2
Claustrum7.02 ± 0.17
Epithalamus7.9 ± 0.19
Frontal Lobe7.53 ± 0.32
Globus Pallidus8.54 ± 0.17
Hypothalamus7.38 ± 0.36
Insula7.56 ± 0.25
Limbic Lobe7.68 ± 0.3
Mesencephalon7.66 ± 0.29
Myelencephalon7.56 ± 0.38
Occipital Lobe7.51 ± 0.36
Parietal Lobe7.54 ± 0.35
Pontine Tegmentum7.67 ± 0.3
Striatum7.62 ± 0.38
Subthalamus7.74 ± 0.06
Temporal Lobe7.52 ± 0.28
Thalamus7.7 ± 0.22
White Matter8.43 ± 0.37
Mouse Brain ISH
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018