AutismKB 2.0

Annotation Detail for PCMT1


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Basic Information Top
Gene Symbol:PCMT1 ( - )
Gene Full Name: protein-L-isoaspartate (D-aspartate) O-methyltransferase
Band: 6q25.1
Quick LinksEntrez ID:5110; OMIM: 176851; Uniprot ID:PIMT_HUMAN; ENSEMBL ID: ENSG00000120265; HGNC ID: 8728
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body4 / 7076156
blastocyst6 / 6231996
fetus46 / 56401281
neonate1 / 3109732
infant18 / 23620762
juvenile5 / 5555689
adult213 / 1939121109
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma1 / 1747557
breast (mammary gland) tumor13 / 94178138
cervical tumor2 / 3436658
chondrosarcoma11 / 82823132
colorectal tumor10 / 11424687
esophageal tumor3 / 17290173
gastrointestinal tumor16 / 119369134
germ cell tumor11 / 26384541
glioma5 / 10688346
head and neck tumor15 / 136302110
kidney tumor5 / 6895972
leukemia12 / 95842125
liver tumor8 / 9635983
lung tumor9 / 10312787
lymphoma4 / 7175555
non-neoplasia35 / 97250359
normal424 / 3360307126
ovarian tumor6 / 7668278
pancreatic tumor12 / 104616114
primitive neuroectodermal tumor of the CNS35 / 125680278
prostate cancer12 / 102680116
retinoblastoma4 / 4635686
skin tumor31 / 124949248
soft tissue/muscle tissue tumor16 / 125191127
uterine tumor8 / 9025788
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue4 / 13106305
adrenal gland1 / 3319730
ascites7 / 40015174
bladder1 / 2975733
blood11 / 12347889
bone12 / 71655167
bone marrow7 / 48801143
brain304 / 1100989276
cervix4 / 4817183
connective tissue19 / 149255127
ear2 / 16212123
embryonic tissue22 / 215722101
esophagus5 / 20209247
eye23 / 211054108
heart20 / 89626223
intestine27 / 234472115
kidney15 / 21177770
larynx1 / 2414541
liver20 / 20774396
lung33 / 33697497
lymph3 / 4427067
lymph node3 / 9161032
mammary gland23 / 153271150
mouth10 / 67052149
muscle12 / 107715111
nerve3 / 15768190
ovary7 / 10205168
pancreas19 / 21481288
parathyroid3 / 20539146
pharynx3 / 4132872
pituitary gland4 / 16585241
placenta25 / 28082589
prostate17 / 18934589
salivary gland3 / 20155148
skin39 / 210574185
spleen3 / 5395255
stomach8 / 9661982
testis42 / 330442127
thymus0 / 811310 
thyroid3 / 4747363
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord1 / 1368073
uterus24 / 232878103
vascular4 / 5178077
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 210156_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts445.25
Adipocyte156.05
AdrenalCortex139.9
Adrenalgland94.5
Amygdala264.6
Appendix122.25
AtrioventricularNode117.6
BDCA4+_DentriticCells186.3
Bonemarrow159.95
BronchialEpithelialCells280.85
CD105+_Endothelial238.05
CD14+_Monocytes395.05
CD19+_BCells(neg._sel.)167
CD33+_Myeloid533.15
CD34+218.4
CD4+_Tcells194.65
CD56+_NKCells206.75
CD71+_EarlyErythroid503.7
CD8+_Tcells144.55
CardiacMyocytes245.55
Caudatenucleus151.6
Cerebellum104.85
CerebellumPeduncles161.1
CiliaryGanglion108.6
CingulateCortex187.05
Colorectaladenocarcinoma168.5
DorsalRootGanglion126.65
FetalThyroid119.1
Fetalbrain174.3
Fetalliver124.45
Fetallung100
GlobusPallidus202.2
Heart106.4
Hypothalamus229.05
Kidney79.65
Leukemia_chronicMyelogenousK-562224
Leukemia_promyelocytic-HL-60217.1
Leukemialymphoblastic(MOLT-4)143.35
Liver102.15
Lung144.6
Lymphnode76.75
Lymphoma_burkitts(Daudi)199
Lymphoma_burkitts(Raji)267.05
MedullaOblongata157.55
OccipitalLobe313.3
OlfactoryBulb136.95
Ovary85.25
Pancreas107.35
PancreaticIslet160.9
ParietalLobe251.35
Pituitary160.5
Placenta150.4
Pons150.1
PrefrontalCortex213.1
Prostate155.5
Salivarygland106.05
SkeletalMuscle95.3
Skin114.5
SmoothMuscle271.6
Spinalcord145.55
SubthalamicNucleus192.9
SuperiorCervicalGanglion133.9
TemporalLobe202.85
Testis191.05
TestisGermCell315.75
TestisIntersitial355.4
TestisLeydigCell266.1
TestisSeminiferousTubule213.45
Thalamus254.65
Thymus121.6
Thyroid170
Tongue96.8
Tonsil122.4
Trachea117.2
TrigeminalGanglion135.35
Uterus113.1
UterusCorpus99.2
WholeBlood175.05
Wholebrain362.5
colon160.35
pineal_day171.28
pineal_night185.46
retina158.725
small_intestine153.9
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P283320
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.41 ± 0.29
Basal Forebrain6.85 ± 0.17
Basal Part of Pons7.38 ± 0.23
Cerebellar Cortex7.01 ± 0.32
Cerebellar Nuclei6.91 ± 0.59
Claustrum7.1 ± 0.39
Epithalamus6.67 ± 0.37
Frontal Lobe7.29 ± 0.36
Globus Pallidus6.17 ± 0.57
Hypothalamus7.16 ± 0.33
Insula7.13 ± 0.32
Limbic Lobe7.21 ± 0.42
Mesencephalon6.89 ± 0.61
Myelencephalon6.98 ± 0.51
Occipital Lobe6.71 ± 0.54
Parietal Lobe7.08 ± 0.47
Pontine Tegmentum7.09 ± 0.46
Striatum6.62 ± 0.55
Subthalamus6.78 ± 0.44
Temporal Lobe7.19 ± 0.38
Thalamus6.83 ± 0.48
White Matter6.59 ± 0.2
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Pcmt1CBCerebellum1.51
2.35
Pcmt1CTXCerebral cortex2.29
2.09
Pcmt1HIPHippocampal region5.72
6.1
Pcmt1HPFHippocampal formation3.97
3.87
Pcmt1HYHypothalamus0.52
0.59
Pcmt1LSXLateral septal complex0.18
0.1
Pcmt1MBMidbrain1.63
2.18
Pcmt1MYMedulla6.14
9.61
Pcmt1OLFOlfactory bulb1.2
2.25
Pcmt1PPons4.63
7.65
Pcmt1PALPallidum0.46
0.53
Pcmt1RHPRetrohippocampal region0.94
0.66
Pcmt1sAMYStriatum-like amygdalar nuclei0.2
0.18
Pcmt1STRStriatum0.22
0.26
Pcmt1STRdStriatum dorsal region0.22
0.26
Pcmt1STRvStriatum ventral region0.17
0.17
Pcmt1THThalamus0.82
0.89
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00000520 17 140 156 ALDVGSGSGILTACFAR Peptide Atlas
PIMT_HUMAN_105 19 105 123 VIGIDHIKELVDDSINNVR PRIDE
PIMT_HUMAN_113 11 113 123 ELVDDSINNVR PRIDE
PIMT_HUMAN_124 11 124 134 KDDPTLLSSGR PRIDE
PIMT_HUMAN_125 19 125 143 DDPTLLSSGRVQLVVGDGR PRIDE
PIMT_HUMAN_135 9 135 143 VQLVVGDGR PRIDE
PIMT_HUMAN_144 34 144 177 MGYAEEAPYDAIHVGAAAPVVPQALIDQLKPGGR PRIDE
PIMT_HUMAN_178 26 178 203 LILPVGPAGGNQMLEQYDKLQDGSIK PRIDE
PIMT_HUMAN_204 15 204 218 MKPLMGVIYVPLTDK PRIDE
PIMT_HUMAN_204 17 204 220 MKPLMGVIYVPLTDKEK PRIDE
PIMT_HUMAN_24 13 24 36 TDKVFEVMLATDR PRIDE
PIMT_HUMAN_4 14 4 17 SGGASHSELIHNLR PRIDE
PIMT_HUMAN_81 17 81 97 ALDVGSGSGILTACFAR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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