AutismKB 2.0

Annotation Detail for METTL9


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Basic Information Top
Gene Symbol:METTL9 ( DREV,DREV1,FLJ21912,PAP1 )
Gene Full Name: methyltransferase like 9
Band: 16p12.2
Quick LinksEntrez ID:51108; OMIM: 609388; Uniprot ID:METL9_HUMAN; ENSEMBL ID: ENSG00000197006; HGNC ID: 24586
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body5 / 7076170
blastocyst3 / 6231948
fetus70 / 564012124
neonate0 / 310970 
infant2 / 2362084
juvenile3 / 5555653
adult184 / 193912194
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma3 / 17475171
breast (mammary gland) tumor15 / 94178159
cervical tumor4 / 34366116
chondrosarcoma12 / 82823144
colorectal tumor8 / 11424670
esophageal tumor1 / 1729057
gastrointestinal tumor16 / 119369134
germ cell tumor9 / 26384534
glioma16 / 106883149
head and neck tumor1 / 1363027
kidney tumor2 / 6895929
leukemia8 / 9584283
liver tumor6 / 9635962
lung tumor1 / 1031279
lymphoma2 / 7175527
non-neoplasia3 / 9725030
normal312 / 336030792
ovarian tumor11 / 76682143
pancreatic tumor3 / 10461628
primitive neuroectodermal tumor of the CNS7 / 12568055
prostate cancer9 / 10268087
retinoblastoma7 / 46356151
skin tumor12 / 12494996
soft tissue/muscle tissue tumor27 / 125191215
uterine tumor7 / 9025777
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland4 / 33197120
ascites3 / 4001574
bladder2 / 2975767
blood5 / 12347840
bone19 / 71655265
bone marrow7 / 48801143
brain70 / 110098963
cervix10 / 48171207
connective tissue28 / 149255187
ear0 / 162120 
embryonic tissue22 / 215722101
esophagus1 / 2020949
eye27 / 211054127
heart5 / 8962655
intestine19 / 23447281
kidney24 / 211777113
larynx0 / 241450 
liver8 / 20774338
lung36 / 336974106
lymph0 / 442700 
lymph node13 / 91610141
mammary gland24 / 153271156
mouth0 / 670520 
muscle9 / 10771583
nerve2 / 15768126
ovary12 / 102051117
pancreas21 / 21481297
parathyroid9 / 20539438
pharynx3 / 4132872
pituitary gland1 / 1658560
placenta14 / 28082549
prostate11 / 18934558
salivary gland1 / 2015549
skin63 / 210574299
spleen2 / 5395237
stomach16 / 96619165
testis18 / 33044254
thymus2 / 8113124
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus20 / 23287885
vascular2 / 5178038
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 217868_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts473.15
Adipocyte363.15
AdrenalCortex385.35
Adrenalgland605.95
Amygdala405.65
Appendix191.85
AtrioventricularNode129.75
BDCA4+_DentriticCells691.35
Bonemarrow636.55
BronchialEpithelialCells644.7
CD105+_Endothelial743.3
CD14+_Monocytes1308.75
CD19+_BCells(neg._sel.)630.75
CD33+_Myeloid2393.35
CD34+570.15
CD4+_Tcells427.85
CD56+_NKCells595.6
CD71+_EarlyErythroid466.55
CD8+_Tcells372.2
CardiacMyocytes292.25
Caudatenucleus320.6
Cerebellum115.45
CerebellumPeduncles178.3
CiliaryGanglion143.2
CingulateCortex240.95
Colorectaladenocarcinoma1067.3
DorsalRootGanglion105.75
FetalThyroid332.15
Fetalbrain416.35
Fetalliver207.45
Fetallung279.65
GlobusPallidus159.4
Heart178.1
Hypothalamus308.5
Kidney512.8
Leukemia_chronicMyelogenousK-562274.4
Leukemia_promyelocytic-HL-60494.95
Leukemialymphoblastic(MOLT-4)467.8
Liver87.35
Lung384.2
Lymphnode306.4
Lymphoma_burkitts(Daudi)747.05
Lymphoma_burkitts(Raji)488
MedullaOblongata265.75
OccipitalLobe307.6
OlfactoryBulb247.65
Ovary116.75
Pancreas232
PancreaticIslet328.8
ParietalLobe173.95
Pituitary440.05
Placenta404.9
Pons183.6
PrefrontalCortex293.85
Prostate585
Salivarygland260.05
SkeletalMuscle232.8
Skin133.75
SmoothMuscle428.9
Spinalcord400.9
SubthalamicNucleus203.2
SuperiorCervicalGanglion133.45
TemporalLobe192.15
Testis118.7
TestisGermCell115.7
TestisIntersitial57.5
TestisLeydigCell95.8
TestisSeminiferousTubule55.35
Thalamus274
Thymus376.55
Thyroid636.55
Tongue201.3
Tonsil233.45
Trachea279.7
TrigeminalGanglion47.7
Uterus360.5
UterusCorpus341.2
WholeBlood1109.35
Wholebrain432.2
colon348.95
pineal_day451.22
pineal_night609.1
retina669.6
small_intestine372.1
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P112984
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala8.93 ± 0.34
Basal Forebrain9.2 ± 0.16
Basal Part of Pons8.51 ± 0.3
Cerebellar Cortex8.59 ± 0.2
Cerebellar Nuclei8.69 ± 0.17
Claustrum8.93 ± 0.32
Epithalamus9.36 ± 0.23
Frontal Lobe8.98 ± 0.31
Globus Pallidus9.19 ± 0.17
Hypothalamus8.87 ± 0.24
Insula8.98 ± 0.29
Limbic Lobe8.87 ± 0.35
Mesencephalon9.07 ± 0.31
Myelencephalon9.05 ± 0.4
Occipital Lobe8.81 ± 0.41
Parietal Lobe8.96 ± 0.34
Pontine Tegmentum8.97 ± 0.3
Striatum9.77 ± 0.36
Subthalamus8.52 ± 0.45
Temporal Lobe9.02 ± 0.24
Thalamus9.07 ± 0.33
White Matter8.28 ± 0.32
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Mettl9CBCerebellum13.11
14.66
Mettl9CTXCerebral cortex40.01
31.68
Mettl9HIPHippocampal region29.3
36.57
Mettl9HPFHippocampal formation28.85
30.96
Mettl9HYHypothalamus16.6
14.89
Mettl9LSXLateral septal complex21.04
16.84
Mettl9MBMidbrain12.09
10.92
Mettl9MYMedulla17.11
17.74
Mettl9OLFOlfactory bulb33.08
26.45
Mettl9PPons12.58
13.53
Mettl9PALPallidum16.95
15.1
Mettl9RHPRetrohippocampal region28.28
22.8
Mettl9sAMYStriatum-like amygdalar nuclei23.61
17.02
Mettl9STRStriatum33.23
24.65
Mettl9STRdStriatum dorsal region34.64
25.93
Mettl9STRvStriatum ventral region42.49
29.97
Mettl9THThalamus16
13.58
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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