AutismKB 2.0

Annotation Detail for LEF1


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Basic Information Top
Gene Symbol:LEF1 ( DKFZp586H0919,FLJ46390,TCF1ALPHA )
Gene Full Name: lymphoid enhancer-binding factor 1
Band: 4q25
Quick LinksEntrez ID:51176; OMIM: 153245; Uniprot ID:LEF1_HUMAN; ENSEMBL ID: ENSG00000138795; HGNC ID: 6551
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body7 / 7076198
blastocyst2 / 6231932
fetus30 / 56401253
neonate0 / 310970 
infant0 / 236200 
juvenile9 / 55556161
adult28 / 193912114
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor1 / 9417810
cervical tumor1 / 3436629
chondrosarcoma0 / 828230 
colorectal tumor1 / 1142468
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor64 / 263845242
glioma0 / 1068830 
head and neck tumor3 / 13630222
kidney tumor1 / 6895914
leukemia26 / 95842271
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma2 / 7175527
non-neoplasia0 / 972500 
normal99 / 336030729
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS2 / 12568015
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor28 / 124949224
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor5 / 9025755
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites0 / 400150 
bladder0 / 297570 
blood15 / 123478121
bone0 / 716550 
bone marrow2 / 4880140
brain10 / 11009899
cervix1 / 4817120
connective tissue1 / 1492556
ear2 / 16212123
embryonic tissue9 / 21572241
esophagus0 / 202090 
eye2 / 2110549
heart10 / 89626111
intestine6 / 23447225
kidney5 / 21177723
larynx1 / 2414541
liver2 / 2077439
lung3 / 3369748
lymph0 / 442700 
lymph node5 / 9161054
mammary gland1 / 1532716
mouth2 / 6705229
muscle2 / 10771518
nerve0 / 157680 
ovary0 / 1020510 
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx4 / 4132896
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate2 / 18934510
salivary gland0 / 201550 
skin29 / 210574137
spleen3 / 5395255
stomach2 / 9661920
testis46 / 330442139
thymus75 / 81131924
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus6 / 23287825
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 210948_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts6.65
Adipocyte6.25
AdrenalCortex10.55
Adrenalgland5.8
Amygdala6.45
Appendix8.2
AtrioventricularNode6.6
BDCA4+_DentriticCells7
Bonemarrow7.95
BronchialEpithelialCells5.7
CD105+_Endothelial6.65
CD14+_Monocytes6.9
CD19+_BCells(neg._sel.)6.55
CD33+_Myeloid7.85
CD34+8.35
CD4+_Tcells165.4
CD56+_NKCells8.1
CD71+_EarlyErythroid6.25
CD8+_Tcells131.9
CardiacMyocytes14.95
Caudatenucleus5.85
Cerebellum5.4
CerebellumPeduncles8
CiliaryGanglion5.3
CingulateCortex6.9
Colorectaladenocarcinoma6.7
DorsalRootGanglion6.75
FetalThyroid6.75
Fetalbrain5.9
Fetalliver5.9
Fetallung4.95
GlobusPallidus5.1
Heart9.6
Hypothalamus6.75
Kidney6.3
Leukemia_chronicMyelogenousK-5625.8
Leukemia_promyelocytic-HL-605.55
Leukemialymphoblastic(MOLT-4)126.1
Liver10.4
Lung6.9
Lymphnode6.15
Lymphoma_burkitts(Daudi)8.7
Lymphoma_burkitts(Raji)9.85
MedullaOblongata5.75
OccipitalLobe5.65
OlfactoryBulb5.05
Ovary5.25
Pancreas6.05
PancreaticIslet6.95
ParietalLobe7.2
Pituitary7.55
Placenta6.4
Pons6.4
PrefrontalCortex7.75
Prostate7.65
Salivarygland5.45
SkeletalMuscle9.45
Skin5.65
SmoothMuscle7.2
Spinalcord6.75
SubthalamicNucleus6.6
SuperiorCervicalGanglion13.7
TemporalLobe6.15
Testis5.4
TestisGermCell5.45
TestisIntersitial8.7
TestisLeydigCell7.45
TestisSeminiferousTubule5.6
Thalamus7
Thymus287.9
Thyroid7.75
Tongue7
Tonsil6.55
Trachea5.3
TrigeminalGanglion9.6
Uterus5.05
UterusCorpus11.15
WholeBlood8.25
Wholebrain5.15
colon6.45
pineal_day7.82
pineal_night7.72
retina7.975
small_intestine6.15
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P213045
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.39 ± 0.5
Basal Forebrain4.47 ± 0.45
Basal Part of Pons4.59 ± 0.36
Cerebellar Cortex4.26 ± 0.5
Cerebellar Nuclei5.54 ± 0.46
Claustrum4.72 ± 0.81
Epithalamus5.16 ± 0.69
Frontal Lobe4.77 ± 0.69
Globus Pallidus6.05 ± 0.44
Hypothalamus5.11 ± 0.68
Insula4.41 ± 0.92
Limbic Lobe4.59 ± 0.74
Mesencephalon4.95 ± 0.6
Myelencephalon5.02 ± 0.69
Occipital Lobe5.4 ± 0.72
Parietal Lobe4.91 ± 0.66
Pontine Tegmentum5.14 ± 0.83
Striatum5.72 ± 0.65
Subthalamus4.79 ± 0.41
Temporal Lobe4.74 ± 0.73
Thalamus5.86 ± 0.73
White Matter5.73 ± 0.64
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Lef1CBCerebellum0.45
0.75
Lef1CTXCerebral cortex0.41
0.45
Lef1HIPHippocampal region0.57
0.71
Lef1HPFHippocampal formation0.52
0.58
Lef1HYHypothalamus0.38
0.41
Lef1LSXLateral septal complex0.09
0.07
Lef1MBMidbrain0.45
0.48
Lef1MYMedulla0.36
0.46
Lef1OLFOlfactory bulb0.55
0.89
Lef1PPons0.27
0.27
Lef1PALPallidum0.13
0.15
Lef1RHPRetrohippocampal region0.45
0.39
Lef1sAMYStriatum-like amygdalar nuclei0.34
0.49
Lef1STRStriatum0.24
0.24
Lef1STRdStriatum dorsal region0.22
0.23
Lef1STRvStriatum ventral region0.35
0.24
Lef1THThalamus12.78
12.08
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
LEF1_HUMAN_75 14 75 88 QAQTSQEPYHDKAR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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