AutismKB 2.0

Annotation Detail for CRIM1


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Basic Information Top
Gene Symbol:CRIM1 ( MGC138194,S52 )
Gene Full Name: cysteine rich transmembrane BMP regulator 1 (chordin-like)
Band: 2p22.2
Quick LinksEntrez ID:51232; OMIM: 606189; Uniprot ID:CRIM1_HUMAN; ENSEMBL ID: ENSG00000150938; HGNC ID: 2359
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body6 / 7076184
blastocyst1 / 6231916
fetus34 / 56401260
neonate0 / 310970 
infant0 / 236200 
juvenile4 / 5555671
adult111 / 193912157
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor1 / 9417810
cervical tumor1 / 3436629
chondrosarcoma10 / 82823120
colorectal tumor4 / 11424635
esophageal tumor0 / 172900 
gastrointestinal tumor4 / 11936933
germ cell tumor1 / 2638453
glioma3 / 10688328
head and neck tumor3 / 13630222
kidney tumor4 / 6895958
leukemia2 / 9584220
liver tumor4 / 9635941
lung tumor1 / 1031279
lymphoma1 / 7175513
non-neoplasia3 / 9725030
normal202 / 336030760
ovarian tumor4 / 7668252
pancreatic tumor2 / 10461619
primitive neuroectodermal tumor of the CNS2 / 12568015
prostate cancer0 / 1026800 
retinoblastoma1 / 4635621
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor7 / 12519155
uterine tumor2 / 9025722
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland1 / 3319730
ascites0 / 400150 
bladder1 / 2975733
blood1 / 1234788
bone5 / 7165569
bone marrow0 / 488010 
brain18 / 110098916
cervix1 / 4817120
connective tissue13 / 14925587
ear3 / 16212185
embryonic tissue10 / 21572246
esophagus0 / 202090 
eye18 / 21105485
heart5 / 8962655
intestine8 / 23447234
kidney19 / 21177789
larynx0 / 241450 
liver8 / 20774338
lung13 / 33697438
lymph0 / 442700 
lymph node1 / 9161010
mammary gland4 / 15327126
mouth2 / 6705229
muscle2 / 10771518
nerve2 / 15768126
ovary4 / 10205139
pancreas5 / 21481223
parathyroid0 / 205390 
pharynx1 / 4132824
pituitary gland6 / 16585361
placenta43 / 280825153
prostate3 / 18934515
salivary gland0 / 201550 
skin19 / 21057490
spleen0 / 539520 
stomach5 / 9661951
testis2 / 3304426
thymus1 / 8113112
thyroid1 / 4747321
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus5 / 23287821
vascular22 / 51780424
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 202551_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts11.55
Adipocyte32.35
AdrenalCortex16.95
Adrenalgland13.75
Amygdala54.95
Appendix18.85
AtrioventricularNode12.1
BDCA4+_DentriticCells25.9
Bonemarrow15.75
BronchialEpithelialCells71
CD105+_Endothelial15.65
CD14+_Monocytes14.7
CD19+_BCells(neg._sel.)16.25
CD33+_Myeloid16.45
CD34+19.15
CD4+_Tcells10.35
CD56+_NKCells18
CD71+_EarlyErythroid14
CD8+_Tcells11.85
CardiacMyocytes140.75
Caudatenucleus17.6
Cerebellum11.5
CerebellumPeduncles17.8
CiliaryGanglion12.2
CingulateCortex16.3
Colorectaladenocarcinoma49
DorsalRootGanglion13.9
FetalThyroid18.55
Fetalbrain22.95
Fetalliver13.55
Fetallung42.35
GlobusPallidus11.95
Heart20.65
Hypothalamus24.05
Kidney58.5
Leukemia_chronicMyelogenousK-56210.6
Leukemia_promyelocytic-HL-6010.55
Leukemialymphoblastic(MOLT-4)8.3
Liver20.75
Lung51.1
Lymphnode47.8
Lymphoma_burkitts(Daudi)18.15
Lymphoma_burkitts(Raji)22
MedullaOblongata14.6
OccipitalLobe27.9
OlfactoryBulb30.9
Ovary10.85
Pancreas14.85
PancreaticIslet24.05
ParietalLobe16.8
Pituitary22.25
Placenta1346.4
Pons15.2
PrefrontalCortex73.05
Prostate69.75
Salivarygland13
SkeletalMuscle19.05
Skin12.85
SmoothMuscle331.8
Spinalcord17.4
SubthalamicNucleus15.6
SuperiorCervicalGanglion18.35
TemporalLobe14.65
Testis13.25
TestisGermCell24
TestisIntersitial13.45
TestisLeydigCell15.05
TestisSeminiferousTubule13.5
Thalamus16.3
Thymus14.65
Thyroid105.8
Tongue16.75
Tonsil13.45
Trachea31.35
TrigeminalGanglion16.15
Uterus128.15
UterusCorpus14.5
WholeBlood12.65
Wholebrain14.9
colon50.05
pineal_day30.92
pineal_night37.44
retina111.6
small_intestine66.25
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P323395
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala8.96 ± 0.34
Basal Forebrain8.3 ± 0.34
Basal Part of Pons8.26 ± 0.41
Cerebellar Cortex7.82 ± 0.29
Cerebellar Nuclei7.74 ± 0.23
Claustrum8.87 ± 0.62
Epithalamus7.93 ± 0.38
Frontal Lobe8.18 ± 0.46
Globus Pallidus8.12 ± 0.21
Hypothalamus8.42 ± 0.64
Insula8.18 ± 0.29
Limbic Lobe8.37 ± 0.5
Mesencephalon8.31 ± 0.51
Myelencephalon8.38 ± 0.35
Occipital Lobe8.19 ± 0.33
Parietal Lobe8.22 ± 0.53
Pontine Tegmentum8.23 ± 0.47
Striatum8.82 ± 0.29
Subthalamus8.19 ± 0.29
Temporal Lobe8.22 ± 0.36
Thalamus8.17 ± 0.43
White Matter7.75 ± 0.44
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Crim1CBCerebellum8.19
9.28
Crim1CTXCerebral cortex14.88
13.42
Crim1HIPHippocampal region28.13
50.58
Crim1HPFHippocampal formation31.35
43.96
Crim1HYHypothalamus5.7
5.32
Crim1LSXLateral septal complex10.06
8.13
Crim1MBMidbrain3.61
3.92
Crim1MYMedulla7.21
8.77
Crim1OLFOlfactory bulb22.52
22.64
Crim1PPons5.89
6.99
Crim1PALPallidum7.05
7.03
Crim1RHPRetrohippocampal region36.83
37.35
Crim1sAMYStriatum-like amygdalar nuclei20.95
20.37
Crim1STRStriatum4.78
4.23
Crim1STRdStriatum dorsal region2.37
2.09
Crim1STRvStriatum ventral region2.46
1.78
Crim1THThalamus14.55
14.83
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00097058 18 975 992 TPTKPSSLNNQLVSVDCK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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