AutismKB 2.0

Annotation Detail for NRN1


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Basic Information Top
Gene Symbol:NRN1 ( MGC44811,NRN,dJ380B8.2 )
Gene Full Name: neuritin 1
Band: 6p25.1
Quick LinksEntrez ID:51299; OMIM: 607409; Uniprot ID:NRN1_HUMAN; ENSEMBL ID: ENSG00000124785; HGNC ID: 17972
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst1 / 6231916
fetus25 / 56401244
neonate0 / 310970 
infant2 / 2362084
juvenile2 / 5555635
adult73 / 193912137
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor2 / 9417821
cervical tumor0 / 343660 
chondrosarcoma12 / 82823144
colorectal tumor1 / 1142468
esophageal tumor1 / 1729057
gastrointestinal tumor0 / 1193690 
germ cell tumor3 / 26384511
glioma14 / 106883130
head and neck tumor5 / 13630236
kidney tumor0 / 689590 
leukemia2 / 9584220
liver tumor4 / 9635941
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia8 / 9725082
normal118 / 336030735
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS6 / 12568047
prostate cancer2 / 10268019
retinoblastoma0 / 463560 
skin tumor11 / 12494988
soft tissue/muscle tissue tumor2 / 12519115
uterine tumor4 / 9025744
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites0 / 400150 
bladder0 / 297570 
blood3 / 12347824
bone11 / 71655153
bone marrow0 / 488010 
brain81 / 110098973
cervix0 / 481710 
connective tissue8 / 14925553
ear0 / 162120 
embryonic tissue3 / 21572213
esophagus1 / 2020949
eye5 / 21105423
heart11 / 89626122
intestine2 / 2344728
kidney3 / 21177714
larynx0 / 241450 
liver4 / 20774319
lung8 / 33697423
lymph0 / 442700 
lymph node0 / 916100 
mammary gland3 / 15327119
mouth0 / 670520 
muscle3 / 10771527
nerve2 / 15768126
ovary0 / 1020510 
pancreas1 / 2148124
parathyroid0 / 205390 
pharynx1 / 4132824
pituitary gland3 / 16585180
placenta19 / 28082567
prostate2 / 18934510
salivary gland4 / 20155198
skin13 / 21057461
spleen1 / 5395218
stomach0 / 966190 
testis0 / 3304420 
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea2 / 5241338
umbilical cord0 / 136800 
uterus9 / 23287838
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 218625_at
Cell line Expression level Expression bar
721_B_lymphoblasts193.95
Adipocyte58.75
AdrenalCortex10.7
Adrenalgland8.95
Amygdala1110.45
Appendix21.45
AtrioventricularNode33.3
BDCA4+_DentriticCells8.6
Bonemarrow9.9
BronchialEpithelialCells10.15
CD105+_Endothelial8.3
CD14+_Monocytes9.4
CD19+_BCells(neg._sel.)8.3
CD33+_Myeloid8.95
CD34+11.35
CD4+_Tcells9.65
CD56+_NKCells8.85
CD71+_EarlyErythroid7.1
CD8+_Tcells7.6
CardiacMyocytes12.55
Caudatenucleus10.7
Cerebellum693.95
CerebellumPeduncles642.05
CiliaryGanglion22.45
CingulateCortex642.65
Colorectaladenocarcinoma9.8
DorsalRootGanglion81.35
FetalThyroid10.35
Fetalbrain21.6
Fetalliver8.7
Fetallung10.7
GlobusPallidus272.6
Heart12.8
Hypothalamus204.15
Kidney8.7
Leukemia_chronicMyelogenousK-5629.6
Leukemia_promyelocytic-HL-609
Leukemialymphoblastic(MOLT-4)264.35
Liver12.45
Lung34.05
Lymphnode23.55
Lymphoma_burkitts(Daudi)13.05
Lymphoma_burkitts(Raji)11.25
MedullaOblongata479.3
OccipitalLobe567.4
OlfactoryBulb129.1
Ovary7.2
Pancreas8.1
PancreaticIslet11.2
ParietalLobe456.6
Pituitary12.35
Placenta101.75
Pons206.3
PrefrontalCortex700.7
Prostate12.05
Salivarygland8.05
SkeletalMuscle11.3
Skin10.75
SmoothMuscle10.9
Spinalcord21.9
SubthalamicNucleus398.85
SuperiorCervicalGanglion21.6
TemporalLobe591.85
Testis8.85
TestisGermCell9
TestisIntersitial9
TestisLeydigCell10
TestisSeminiferousTubule8.1
Thalamus331.45
Thymus7.7
Thyroid13.45
Tongue11.45
Tonsil10.1
Trachea17.1
TrigeminalGanglion42.4
Uterus19.85
UterusCorpus9.05
WholeBlood9
Wholebrain1959.15
colon9.15
pineal_day19.72
pineal_night41.5
retina21.8
small_intestine10.35
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P82088
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala10.87 ± 0.72
Basal Forebrain9.16 ± 0.3
Basal Part of Pons11.52 ± 0.28
Cerebellar Cortex10.95 ± 0.15
Cerebellar Nuclei10.89 ± 0.3
Claustrum10.4 ± 0.31
Epithalamus9.72 ± 0.85
Frontal Lobe10.84 ± 0.46
Globus Pallidus9.09 ± 0.46
Hypothalamus9.41 ± 0.49
Insula10.74 ± 0.22
Limbic Lobe10.95 ± 0.59
Mesencephalon10.17 ± 0.53
Myelencephalon10.53 ± 0.72
Occipital Lobe10.53 ± 0.6
Parietal Lobe10.92 ± 0.43
Pontine Tegmentum10.41 ± 0.53
Striatum8.89 ± 0.98
Subthalamus10.71 ± 0.12
Temporal Lobe10.89 ± 0.27
Thalamus10.66 ± 0.38
White Matter8.94 ± 0.33
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Nrn1CBCerebellum62.44
88.96
Nrn1CTXCerebral cortex100
100
Nrn1HIPHippocampal region100
100
Nrn1HPFHippocampal formation100
100
Nrn1HYHypothalamus58.57
51.62
Nrn1LSXLateral septal complex20.53
28.44
Nrn1MBMidbrain91.55
100
Nrn1MYMedulla73.32
100
Nrn1OLFOlfactory bulb100
100
Nrn1PPons74.25
100
Nrn1PALPallidum17.04
15.92
Nrn1RHPRetrohippocampal region94.3
100
Nrn1sAMYStriatum-like amygdalar nuclei55.38
64.35
Nrn1STRStriatum13.64
14.88
Nrn1STRdStriatum dorsal region6.11
4.06
Nrn1STRvStriatum ventral region13.81
12.54
Nrn1THThalamus100
100
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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