AutismKB 2.0

Annotation Detail for PHF21A


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Basic Information Top
Gene Symbol:PHF21A ( BHC80,KIAA1696 )
Gene Full Name: PHD finger protein 21A
Band: 11p11.2
Quick LinksEntrez ID:51317; OMIM: 608325; Uniprot ID:PF21A_HUMAN; ENSEMBL ID: ENSG00000135365; HGNC ID: 24156
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body2 / 7076128
blastocyst2 / 6231932
fetus37 / 56401265
neonate0 / 310970 
infant0 / 236200 
juvenile1 / 5555617
adult118 / 193912160
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma1 / 1747557
breast (mammary gland) tumor5 / 9417853
cervical tumor6 / 34366174
chondrosarcoma6 / 8282372
colorectal tumor2 / 11424617
esophageal tumor0 / 172900 
gastrointestinal tumor3 / 11936925
germ cell tumor15 / 26384556
glioma11 / 106883102
head and neck tumor3 / 13630222
kidney tumor8 / 68959116
leukemia9 / 9584293
liver tumor6 / 9635962
lung tumor6 / 10312758
lymphoma2 / 7175527
non-neoplasia4 / 9725041
normal152 / 336030745
ovarian tumor5 / 7668265
pancreatic tumor3 / 10461628
primitive neuroectodermal tumor of the CNS2 / 12568015
prostate cancer2 / 10268019
retinoblastoma0 / 463560 
skin tumor1 / 1249498
soft tissue/muscle tissue tumor4 / 12519131
uterine tumor8 / 9025788
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland0 / 331970 
ascites0 / 400150 
bladder3 / 29757100
blood7 / 12347856
bone4 / 7165555
bone marrow5 / 48801102
brain40 / 110098936
cervix10 / 48171207
connective tissue4 / 14925526
ear0 / 162120 
embryonic tissue8 / 21572237
esophagus0 / 202090 
eye9 / 21105442
heart5 / 8962655
intestine6 / 23447225
kidney11 / 21177751
larynx0 / 241450 
liver8 / 20774338
lung29 / 33697486
lymph2 / 4427045
lymph node15 / 91610163
mammary gland6 / 15327139
mouth0 / 670520 
muscle4 / 10771537
nerve1 / 1576863
ovary4 / 10205139
pancreas12 / 21481255
parathyroid0 / 205390 
pharynx3 / 4132872
pituitary gland1 / 1658560
placenta6 / 28082521
prostate4 / 18934521
salivary gland1 / 2015549
skin3 / 21057414
spleen0 / 539520 
stomach3 / 9661931
testis22 / 33044266
thymus4 / 8113149
thyroid2 / 4747342
tonsil1 / 1699958
trachea4 / 5241376
umbilical cord0 / 136800 
uterus12 / 23287851
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 203278_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts53.85
Adipocyte14.45
AdrenalCortex20.2
Adrenalgland12.85
Amygdala19.85
Appendix12.5
AtrioventricularNode10.7
BDCA4+_DentriticCells65.25
Bonemarrow16.65
BronchialEpithelialCells18.4
CD105+_Endothelial22.8
CD14+_Monocytes134.75
CD19+_BCells(neg._sel.)61.1
CD33+_Myeloid162.95
CD34+41.15
CD4+_Tcells59.25
CD56+_NKCells140
CD71+_EarlyErythroid25.15
CD8+_Tcells53.1
CardiacMyocytes33.55
Caudatenucleus14.05
Cerebellum15.35
CerebellumPeduncles19.15
CiliaryGanglion10.15
CingulateCortex17.05
Colorectaladenocarcinoma17.85
DorsalRootGanglion14.35
FetalThyroid16.25
Fetalbrain25.45
Fetalliver15.9
Fetallung15.6
GlobusPallidus13.85
Heart19.55
Hypothalamus18.45
Kidney10.15
Leukemia_chronicMyelogenousK-56217.1
Leukemia_promyelocytic-HL-6017.3
Leukemialymphoblastic(MOLT-4)13.35
Liver21.55
Lung16.75
Lymphnode16.05
Lymphoma_burkitts(Daudi)29.15
Lymphoma_burkitts(Raji)52.65
MedullaOblongata15.35
OccipitalLobe14.3
OlfactoryBulb17.3
Ovary11.9
Pancreas13.45
PancreaticIslet19.95
ParietalLobe14.4
Pituitary19.25
Placenta18.6
Pons14.4
PrefrontalCortex23.6
Prostate22.7
Salivarygland15.25
SkeletalMuscle23.8
Skin15.05
SmoothMuscle22.6
Spinalcord19.85
SubthalamicNucleus14.85
SuperiorCervicalGanglion14.7
TemporalLobe9.95
Testis23.2
TestisGermCell17.05
TestisIntersitial16.9
TestisLeydigCell19
TestisSeminiferousTubule23.3
Thalamus12.15
Thymus14.9
Thyroid23.75
Tongue17.4
Tonsil15.4
Trachea10.15
TrigeminalGanglion17.05
Uterus15.35
UterusCorpus17.9
WholeBlood81.75
Wholebrain16.7
colon18.9
pineal_day52.92
pineal_night37.1
retina20.85
small_intestine18.4
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P41524
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.32 ± 0.62
Basal Forebrain5.41 ± 0.2
Basal Part of Pons4.64 ± 0.46
Cerebellar Cortex5.14 ± 0.35
Cerebellar Nuclei5.2 ± 0.43
Claustrum5.31 ± 0.62
Epithalamus4.98 ± 0.27
Frontal Lobe4.77 ± 0.46
Globus Pallidus5.64 ± 0.31
Hypothalamus4.61 ± 0.56
Insula4.87 ± 0.34
Limbic Lobe4.95 ± 0.48
Mesencephalon5.12 ± 0.49
Myelencephalon4.98 ± 0.49
Occipital Lobe5.37 ± 0.49
Parietal Lobe5.04 ± 0.39
Pontine Tegmentum5.08 ± 0.5
Striatum5.26 ± 0.54
Subthalamus5.04 ± 0.34
Temporal Lobe4.91 ± 0.4
Thalamus4.98 ± 0.4
White Matter5.77 ± 0.27
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Phf21aCBCerebellum14.89
18.27
Phf21aCTXCerebral cortex18.07
13.75
Phf21aHPFHippocampal formation16.66
17.76
Phf21aLSXLateral septal complex0.87
0.61
Phf21aMBMidbrain3.3
3.14
Phf21aMYMedulla10.42
11.54
Phf21aPALPallidum10.96
10.77
Phf21aRHPRetrohippocampal region11.81
8.86
Phf21asAMYStriatum-like amygdalar nuclei14.24
11.18
Phf21aSTRdStriatum dorsal region15.05
11.4
Phf21aTHThalamus13.44
12.89
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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