AutismKB 2.0

Annotation Detail for TNFRSF12A


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Basic Information Top
Gene Symbol:TNFRSF12A ( CD266,FN14,TWEAKR )
Gene Full Name: tumor necrosis factor receptor superfamily, member 12A
Band: 16p13.3
Quick LinksEntrez ID:51330; OMIM: 605914; Uniprot ID:TNR12_HUMAN; ENSEMBL ID: ENSG00000006327; HGNC ID: 18152
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body14 / 70761197
blastocyst2 / 6231932
fetus2 / 5640123
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult91 / 193912146
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma1 / 1747557
breast (mammary gland) tumor14 / 94178148
cervical tumor0 / 343660 
chondrosarcoma13 / 82823156
colorectal tumor6 / 11424652
esophageal tumor0 / 172900 
gastrointestinal tumor31 / 119369259
germ cell tumor2 / 2638457
glioma7 / 10688365
head and neck tumor6 / 13630244
kidney tumor14 / 68959203
leukemia1 / 9584210
liver tumor0 / 963590 
lung tumor12 / 103127116
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal88 / 336030726
ovarian tumor1 / 7668213
pancreatic tumor19 / 104616181
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer2 / 10268019
retinoblastoma1 / 4635621
skin tumor29 / 124949232
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor9 / 9025799
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites3 / 4001574
bladder0 / 297570 
blood2 / 12347816
bone3 / 7165541
bone marrow0 / 488010 
brain9 / 11009898
cervix2 / 4817141
connective tissue5 / 14925533
ear0 / 162120 
embryonic tissue16 / 21572274
esophagus0 / 202090 
eye7 / 21105433
heart1 / 8962611
intestine12 / 23447251
kidney23 / 211777108
larynx0 / 241450 
liver2 / 2077439
lung25 / 33697474
lymph0 / 442700 
lymph node8 / 9161087
mammary gland17 / 153271110
mouth0 / 670520 
muscle1 / 1077159
nerve0 / 157680 
ovary5 / 10205148
pancreas28 / 214812130
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland1 / 1658560
placenta20 / 28082571
prostate8 / 18934542
salivary gland5 / 20155248
skin31 / 210574147
spleen0 / 539520 
stomach28 / 96619289
testis1 / 3304423
thymus0 / 811310 
thyroid1 / 4747321
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus11 / 23287847
vascular2 / 5178038
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 218368_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts24.45
Adipocyte65.35
AdrenalCortex36.75
Adrenalgland49.5
Amygdala19.8
Appendix24.15
AtrioventricularNode17.9
BDCA4+_DentriticCells20.85
Bonemarrow24.55
BronchialEpithelialCells1045.9
CD105+_Endothelial21.1
CD14+_Monocytes16.45
CD19+_BCells(neg._sel.)18.45
CD33+_Myeloid25.9
CD34+30.05
CD4+_Tcells21.15
CD56+_NKCells17.4
CD71+_EarlyErythroid21.45
CD8+_Tcells18.55
CardiacMyocytes220.15
Caudatenucleus21.3
Cerebellum20.1
CerebellumPeduncles28.25
CiliaryGanglion15.5
CingulateCortex26
Colorectaladenocarcinoma377.1
DorsalRootGanglion17.6
FetalThyroid32.45
Fetalbrain24.05
Fetalliver26.6
Fetallung69.15
GlobusPallidus16.5
Heart250.4
Hypothalamus23.5
Kidney42.95
Leukemia_chronicMyelogenousK-56237.9
Leukemia_promyelocytic-HL-6021.15
Leukemialymphoblastic(MOLT-4)19.4
Liver31
Lung168.65
Lymphnode20.1
Lymphoma_burkitts(Daudi)27.6
Lymphoma_burkitts(Raji)28.95
MedullaOblongata26.95
OccipitalLobe25.95
OlfactoryBulb20.1
Ovary18.4
Pancreas35.95
PancreaticIslet189.7
ParietalLobe32
Pituitary71.7
Placenta293.1
Pons24
PrefrontalCortex20.5
Prostate25.85
Salivarygland22.05
SkeletalMuscle33
Skin17.6
SmoothMuscle484.1
Spinalcord38.85
SubthalamicNucleus22.35
SuperiorCervicalGanglion22
TemporalLobe21.55
Testis19.15
TestisGermCell18.75
TestisIntersitial19.15
TestisLeydigCell28.8
TestisSeminiferousTubule30
Thalamus31.85
Thymus17.25
Thyroid25.35
Tongue26.05
Tonsil26.9
Trachea29.1
TrigeminalGanglion28.8
Uterus20.7
UterusCorpus21.5
WholeBlood24.6
Wholebrain18.35
colon16.35
pineal_day24.06
pineal_night21.32
retina26.6
small_intestine18.9
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_15776_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.59 ± 0.77
Basal Forebrain3.45 ± 0.72
Basal Part of Pons4.36 ± 0.24
Cerebellar Cortex3.93 ± 0.42
Cerebellar Nuclei4.12 ± 0.59
Claustrum3.67 ± 0.89
Epithalamus3.55 ± 0.76
Frontal Lobe3.68 ± 0.65
Globus Pallidus3.99 ± 0.73
Hypothalamus3.57 ± 0.54
Insula3.45 ± 0.66
Limbic Lobe3.7 ± 0.65
Mesencephalon3.66 ± 0.7
Myelencephalon3.62 ± 0.74
Occipital Lobe3.74 ± 0.67
Parietal Lobe3.56 ± 0.7
Pontine Tegmentum3.53 ± 0.62
Striatum3.26 ± 0.62
Subthalamus3.74 ± 0.62
Temporal Lobe3.52 ± 0.71
Thalamus3.56 ± 0.57
White Matter3.72 ± 0.52
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Tnfrsf12aCBCerebellum25
18.11
Tnfrsf12aCTXCerebral cortex29.2
19.67
Tnfrsf12aHIPHippocampal region31.44
18.05
Tnfrsf12aHPFHippocampal formation38.77
25.48
Tnfrsf12aHYHypothalamus38.85
24.12
Tnfrsf12aLSXLateral septal complex8.72
4.33
Tnfrsf12aMBMidbrain22.54
15.66
Tnfrsf12aMYMedulla50.19
45.15
Tnfrsf12aOLFOlfactory bulb43.72
28.33
Tnfrsf12aPPons42.33
37.47
Tnfrsf12aPALPallidum24.76
17.63
Tnfrsf12aRHPRetrohippocampal region53.01
36.79
Tnfrsf12asAMYStriatum-like amygdalar nuclei47.29
27.95
Tnfrsf12aSTRStriatum13.97
8.15
Tnfrsf12aSTRdStriatum dorsal region4.92
2.94
Tnfrsf12aSTRvStriatum ventral region35.34
18.89
Tnfrsf12aTHThalamus14.7
10.14
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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