AutismKB 2.0

Annotation Detail for DACT1


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Basic Information Top
Gene Symbol:DACT1 ( DAPPER,DAPPER1,DPR1,FRODO,HDPR1,THYEX3 )
Gene Full Name: dapper, antagonist of beta-catenin, homolog 1 (Xenopus laevis)
Band: 14q23.1
Quick LinksEntrez ID:51339; OMIM: 607861; Uniprot ID:DACT1_HUMAN; ENSEMBL ID: ENSG00000165617; HGNC ID: 17748
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body6 / 7076184
blastocyst2 / 6231932
fetus39 / 56401269
neonate0 / 310970 
infant2 / 2362084
juvenile1 / 5555617
adult37 / 193912119
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor3 / 9417831
cervical tumor0 / 343660 
chondrosarcoma1 / 8282312
colorectal tumor2 / 11424617
esophageal tumor0 / 172900 
gastrointestinal tumor2 / 11936916
germ cell tumor2 / 2638457
glioma0 / 1068830 
head and neck tumor3 / 13630222
kidney tumor1 / 6895914
leukemia1 / 9584210
liver tumor0 / 963590 
lung tumor2 / 10312719
lymphoma0 / 717550 
non-neoplasia2 / 9725020
normal89 / 336030726
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood1 / 1234788
bone0 / 716550 
bone marrow0 / 488010 
brain25 / 110098922
cervix0 / 481710 
connective tissue2 / 14925513
ear0 / 162120 
embryonic tissue11 / 21572250
esophagus0 / 202090 
eye5 / 21105423
heart1 / 8962611
intestine3 / 23447212
kidney2 / 2117779
larynx0 / 241450 
liver0 / 2077430 
lung3 / 3369748
lymph0 / 442700 
lymph node1 / 9161010
mammary gland3 / 15327119
mouth3 / 6705244
muscle0 / 1077150 
nerve2 / 15768126
ovary0 / 1020510 
pancreas0 / 2148120 
parathyroid1 / 2053948
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta10 / 28082535
prostate1 / 1893455
salivary gland0 / 201550 
skin0 / 2105740 
spleen0 / 539520 
stomach2 / 9661920
testis7 / 33044221
thymus1 / 8113112
thyroid1 / 4747321
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus0 / 2328780 
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 219179_at
Cell line Expression level Expression bar
721_B_lymphoblasts4.35
Adipocyte3.4
AdrenalCortex3.55
Adrenalgland2.9
Amygdala3.7
Appendix3.45
AtrioventricularNode2.6
BDCA4+_DentriticCells4
Bonemarrow3.4
BronchialEpithelialCells3.4
CD105+_Endothelial3.55
CD14+_Monocytes3.7
CD19+_BCells(neg._sel.)3.75
CD33+_Myeloid4.5
CD34+4.45
CD4+_Tcells3.8
CD56+_NKCells4.15
CD71+_EarlyErythroid3.25
CD8+_Tcells3.35
CardiacMyocytes4.5
Caudatenucleus3.1
Cerebellum5.75
CerebellumPeduncles3.95
CiliaryGanglion2.4
CingulateCortex3.5
Colorectaladenocarcinoma3.5
DorsalRootGanglion2.65
FetalThyroid3.4
Fetalbrain320.05
Fetalliver3
Fetallung2.95
GlobusPallidus2.5
Heart4.4
Hypothalamus3.8
Kidney2.75
Leukemia_chronicMyelogenousK-5623.15
Leukemia_promyelocytic-HL-603.1
Leukemialymphoblastic(MOLT-4)2.75
Liver4.55
Lung3.85
Lymphnode3.05
Lymphoma_burkitts(Daudi)4.4
Lymphoma_burkitts(Raji)4.8
MedullaOblongata3.25
OccipitalLobe3.15
OlfactoryBulb2.75
Ovary2.3
Pancreas2.8
PancreaticIslet3.7
ParietalLobe3.65
Pituitary4.05
Placenta3.65
Pons3.3
PrefrontalCortex4.35
Prostate4.1
Salivarygland2.75
SkeletalMuscle3.95
Skin2.65
SmoothMuscle46.3
Spinalcord3.7
SubthalamicNucleus3.15
SuperiorCervicalGanglion3.95
TemporalLobe3.15
Testis3.1
TestisGermCell3.95
TestisIntersitial2.9
TestisLeydigCell3.45
TestisSeminiferousTubule3
Thalamus3.55
Thymus2.75
Thyroid4.45
Tongue3.35
Tonsil3.4
Trachea2.9
TrigeminalGanglion3.55
Uterus2.9
UterusCorpus3.35
WholeBlood3.8
Wholebrain3.05
colon3.5
pineal_day4.34
pineal_night4.24
retina7.625
small_intestine3.4
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P65518
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.77 ± 0.88
Basal Forebrain6.61 ± 0.65
Basal Part of Pons5.72 ± 0.77
Cerebellar Cortex7.62 ± 0.41
Cerebellar Nuclei6.1 ± 0.63
Claustrum5.54 ± 1.07
Epithalamus6.19 ± 0.71
Frontal Lobe6.78 ± 0.64
Globus Pallidus5.34 ± 0.37
Hypothalamus7.72 ± 0.68
Insula7.27 ± 0.41
Limbic Lobe6.58 ± 1.1
Mesencephalon6.56 ± 0.87
Myelencephalon6.59 ± 0.72
Occipital Lobe6.01 ± 0.97
Parietal Lobe6.53 ± 0.55
Pontine Tegmentum6.93 ± 0.72
Striatum5.16 ± 0.81
Subthalamus6.1 ± 0.11
Temporal Lobe7.2 ± 0.57
Thalamus6.55 ± 0.59
White Matter4.9 ± 0.51
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Dact1CBCerebellum7.31
7.09
Dact1CTXCerebral cortex3.77
2.46
Dact1HIPHippocampal region1.74
1.59
Dact1HPFHippocampal formation1.74
1.5
Dact1HYHypothalamus0.3
0.27
Dact1LSXLateral septal complex2.3
1.58
Dact1MBMidbrain0.71
0.79
Dact1MYMedulla2.51
2.29
Dact1OLFOlfactory bulb11.9
9.17
Dact1PPons1.04
1.31
Dact1PALPallidum0.91
0.73
Dact1RHPRetrohippocampal region1.76
1.4
Dact1sAMYStriatum-like amygdalar nuclei0.22
0.22
Dact1STRStriatum1.09
1.23
Dact1STRdStriatum dorsal region0.56
1.22
Dact1STRvStriatum ventral region1.93
1.23
Dact1THThalamus1.3
1.5
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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