AutismKB 2.0

Annotation Detail for PDE1C


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Basic Information Top
Gene Symbol:PDE1C ( Hcam3 )
Gene Full Name: phosphodiesterase 1C, calmodulin-dependent 70kDa
Band: 7p14.3
Quick LinksEntrez ID:5137; OMIM: 602987; Uniprot ID:PDE1C_HUMAN; ENSEMBL ID: ENSG00000154678; HGNC ID: 8776
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Microarray in BioGPS Top
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  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 216869_at
Cell line Expression level Expression bar
721_B_lymphoblasts5.2
Adipocyte4.1
AdrenalCortex4.35
Adrenalgland3.5
Amygdala4.4
Appendix4.2
AtrioventricularNode3.1
BDCA4+_DentriticCells4.7
Bonemarrow4.05
BronchialEpithelialCells4.1
CD105+_Endothelial4.2
CD14+_Monocytes4.4
CD19+_BCells(neg._sel.)4.5
CD33+_Myeloid5.3
CD34+5.3
CD4+_Tcells4.5
CD56+_NKCells4.85
CD71+_EarlyErythroid3.8
CD8+_Tcells3.9
CardiacMyocytes5.6
Caudatenucleus3.7
Cerebellum3.35
CerebellumPeduncles5.1
CiliaryGanglion2.85
CingulateCortex4.2
Colorectaladenocarcinoma4.15
DorsalRootGanglion3.2
FetalThyroid4
Fetalbrain4.2
Fetalliver3.55
Fetallung3.45
GlobusPallidus3.2
Heart5.55
Hypothalamus4.6
Kidney3.4
Leukemia_chronicMyelogenousK-5623.75
Leukemia_promyelocytic-HL-603.65
Leukemialymphoblastic(MOLT-4)3.35
Liver5.45
Lung4.6
Lymphnode3.6
Lymphoma_burkitts(Daudi)5.2
Lymphoma_burkitts(Raji)5.8
MedullaOblongata3.85
OccipitalLobe3.7
OlfactoryBulb3.25
Ovary2.75
Pancreas3.3
PancreaticIslet4.4
ParietalLobe4.5
Pituitary4.9
Placenta4.15
Pons3.95
PrefrontalCortex5.25
Prostate4.8
Salivarygland3.3
SkeletalMuscle5.4
Skin3.2
SmoothMuscle4.75
Spinalcord4.4
SubthalamicNucleus3.75
SuperiorCervicalGanglion4.7
TemporalLobe3.9
Testis3.6
TestisGermCell3.45
TestisIntersitial3.5
TestisLeydigCell4.1
TestisSeminiferousTubule3.55
Thalamus4.2
Thymus3.3
Thyroid5.25
Tongue4.1
Tonsil4
Trachea3.45
TrigeminalGanglion4.2
Uterus3.35
UterusCorpus3.85
WholeBlood4.6
Wholebrain3.5
colon4.1
pineal_day5.58
pineal_night5.14
retina4.925
small_intestine3.95
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P206328
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala8.03 ± 0.54
Basal Forebrain9.04 ± 0.37
Basal Part of Pons8.19 ± 0.28
Cerebellar Cortex7.17 ± 0.47
Cerebellar Nuclei8.08 ± 0.41
Claustrum7.66 ± 0.45
Epithalamus6.93 ± 0.89
Frontal Lobe7.55 ± 0.63
Globus Pallidus9.14 ± 0.34
Hypothalamus7.56 ± 0.63
Insula7.46 ± 0.41
Limbic Lobe7.67 ± 0.81
Mesencephalon7.91 ± 0.64
Myelencephalon7.87 ± 0.61
Occipital Lobe7.91 ± 0.64
Parietal Lobe7.85 ± 0.65
Pontine Tegmentum7.77 ± 0.75
Striatum8.52 ± 0.63
Subthalamus7.72 ± 0.39
Temporal Lobe7.75 ± 0.52
Thalamus7.98 ± 0.47
White Matter10.23 ± 0.59
Mouse Brain ISH
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PDE1C_HUMAN_46 8 46 53 SLVKQLER PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018