AutismKB 2.0

Annotation Detail for UCHL5


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Basic Information Top
Gene Symbol:UCHL5 ( CGI-70,INO80R,UCH37 )
Gene Full Name: ubiquitin carboxyl-terminal hydrolase L5
Band: 1q31.2
Quick LinksEntrez ID:51377; OMIM: 610667; Uniprot ID:UCHL5_HUMAN; ENSEMBL ID: ENSG00000116750; HGNC ID: 19678
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst0 / 623190 
fetus4 / 5640127
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult29 / 193912114
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor3 / 9417831
cervical tumor0 / 343660 
chondrosarcoma1 / 8282312
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor2 / 11936916
germ cell tumor2 / 2638457
glioma0 / 1068830 
head and neck tumor1 / 1363027
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor1 / 1031279
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal45 / 336030713
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor1 / 1249498
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites1 / 4001524
bladder1 / 2975733
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain10 / 11009899
cervix0 / 481710 
connective tissue1 / 1492556
ear0 / 162120 
embryonic tissue1 / 2157224
esophagus0 / 202090 
eye16 / 21105475
heart0 / 896260 
intestine0 / 2344720 
kidney2 / 2117779
larynx0 / 241450 
liver1 / 2077434
lung7 / 33697420
lymph0 / 442700 
lymph node4 / 9161043
mammary gland3 / 15327119
mouth0 / 670520 
muscle0 / 1077150 
nerve0 / 157680 
ovary0 / 1020510 
pancreas1 / 2148124
parathyroid0 / 205390 
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta3 / 28082510
prostate0 / 1893450 
salivary gland0 / 201550 
skin2 / 2105749
spleen0 / 539520 
stomach2 / 9661920
testis2 / 3304426
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus2 / 2328788
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 219960_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts60.1
Adipocyte10.05
AdrenalCortex10.05
Adrenalgland8.15
Amygdala20.45
Appendix12.1
AtrioventricularNode7.7
BDCA4+_DentriticCells18.7
Bonemarrow8.75
BronchialEpithelialCells74.1
CD105+_Endothelial73.8
CD14+_Monocytes9.7
CD19+_BCells(neg._sel.)16.3
CD33+_Myeloid14.35
CD34+18.05
CD4+_Tcells10.35
CD56+_NKCells32.2
CD71+_EarlyErythroid16.95
CD8+_Tcells17.05
CardiacMyocytes13.5
Caudatenucleus8.75
Cerebellum11.9
CerebellumPeduncles11.8
CiliaryGanglion6.85
CingulateCortex12.1
Colorectaladenocarcinoma16.45
DorsalRootGanglion7.35
FetalThyroid10.2
Fetalbrain9.75
Fetalliver18.35
Fetallung9.5
GlobusPallidus7.2
Heart12.9
Hypothalamus11.45
Kidney7.3
Leukemia_chronicMyelogenousK-56251.3
Leukemia_promyelocytic-HL-6059.9
Leukemialymphoblastic(MOLT-4)25.45
Liver12.45
Lung9.7
Lymphnode9.1
Lymphoma_burkitts(Daudi)29.55
Lymphoma_burkitts(Raji)14.3
MedullaOblongata10
OccipitalLobe12.4
OlfactoryBulb7.4
Ovary8
Pancreas8.25
PancreaticIslet13.6
ParietalLobe11.4
Pituitary12.7
Placenta8.95
Pons9.75
PrefrontalCortex16.1
Prostate10.55
Salivarygland9.95
SkeletalMuscle10.6
Skin7.4
SmoothMuscle12.35
Spinalcord9.8
SubthalamicNucleus10.05
SuperiorCervicalGanglion12.5
TemporalLobe9.2
Testis8.2
TestisGermCell7.95
TestisIntersitial7.95
TestisLeydigCell9.4
TestisSeminiferousTubule8
Thalamus10.6
Thymus7.6
Thyroid14.55
Tongue9.95
Tonsil10.1
Trachea8.7
TrigeminalGanglion9.85
Uterus8.9
UterusCorpus9.05
WholeBlood14.85
Wholebrain16.8
colon19.45
pineal_day11.1
pineal_night9.64
retina10.675
small_intestine11.15
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P188325
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala8.64 ± 0.34
Basal Forebrain8.43 ± 0.13
Basal Part of Pons8.98 ± 0.25
Cerebellar Cortex8.82 ± 0.28
Cerebellar Nuclei9.06 ± 0.36
Claustrum8.91 ± 0.41
Epithalamus8.41 ± 0.34
Frontal Lobe8.74 ± 0.3
Globus Pallidus8.38 ± 0.22
Hypothalamus8.55 ± 0.2
Insula8.75 ± 0.19
Limbic Lobe8.81 ± 0.36
Mesencephalon8.66 ± 0.33
Myelencephalon8.65 ± 0.32
Occipital Lobe8.99 ± 0.21
Parietal Lobe8.83 ± 0.3
Pontine Tegmentum8.76 ± 0.24
Striatum8.31 ± 0.25
Subthalamus9.23 ± 0.39
Temporal Lobe8.72 ± 0.26
Thalamus8.62 ± 0.24
White Matter8.16 ± 0.18
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Uchl5CBCerebellum22.42
32.73
Uchl5CTXCerebral cortex93.67
90.9
Uchl5HIPHippocampal region56.59
100
Uchl5HPFHippocampal formation67.22
94.99
Uchl5HYHypothalamus25.01
22.4
Uchl5LSXLateral septal complex16.02
15.48
Uchl5MBMidbrain26.16
29.75
Uchl5MYMedulla29.91
44.63
Uchl5OLFOlfactory bulb55.14
56.19
Uchl5PPons22.41
31.55
Uchl5PALPallidum15.24
19.9
Uchl5RHPRetrohippocampal region84.56
87.89
Uchl5sAMYStriatum-like amygdalar nuclei20.9
18.17
Uchl5STRStriatum13.08
11.93
Uchl5STRdStriatum dorsal region11.9
11.26
Uchl5STRvStriatum ventral region10.62
8.8
Uchl5THThalamus22.92
22.93
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00029570 24 183 206 EGPIDLGACNQDDWISAVRPVIEK Peptide Atlas
UCHL5_HUMAN_146 9 146 154 QQMFEFDTK PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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