AutismKB 2.0

Annotation Detail for CRLF3


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Basic Information Top
Gene Symbol:CRLF3 ( CREME9,CYTOR4,FRWS,MGC20661,p48.2 )
Gene Full Name: cytokine receptor-like factor 3
Band: 17q11.2
Quick LinksEntrez ID:51379; OMIM: NA; Uniprot ID:CRLF3_HUMAN; ENSEMBL ID: ENSG00000176390; HGNC ID: 17177
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body3 / 7076142
blastocyst2 / 6231932
fetus7 / 56401212
neonate1 / 3109732
infant0 / 236200 
juvenile1 / 5555617
adult55 / 193912128
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor6 / 9417863
cervical tumor0 / 343660 
chondrosarcoma5 / 8282360
colorectal tumor3 / 11424626
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor3 / 26384511
glioma0 / 1068830 
head and neck tumor4 / 13630229
kidney tumor0 / 689590 
leukemia1 / 9584210
liver tumor0 / 963590 
lung tumor2 / 10312719
lymphoma3 / 7175541
non-neoplasia5 / 9725051
normal68 / 336030720
ovarian tumor1 / 7668213
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS1 / 1256807
prostate cancer4 / 10268038
retinoblastoma1 / 4635621
skin tumor3 / 12494924
soft tissue/muscle tissue tumor7 / 12519155
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites0 / 400150 
bladder0 / 297570 
blood4 / 12347832
bone4 / 7165555
bone marrow0 / 488010 
brain19 / 110098917
cervix0 / 481710 
connective tissue4 / 14925526
ear0 / 162120 
embryonic tissue6 / 21572227
esophagus0 / 202090 
eye3 / 21105414
heart0 / 896260 
intestine3 / 23447212
kidney0 / 2117770 
larynx0 / 241450 
liver1 / 2077434
lung4 / 33697411
lymph1 / 4427022
lymph node6 / 9161065
mammary gland7 / 15327145
mouth3 / 6705244
muscle5 / 10771546
nerve0 / 157680 
ovary1 / 1020519
pancreas3 / 21481213
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta13 / 28082546
prostate4 / 18934521
salivary gland0 / 201550 
skin4 / 21057418
spleen2 / 5395237
stomach1 / 9661910
testis7 / 33044221
thymus17 / 81131209
thyroid1 / 4747321
tonsil1 / 1699958
trachea0 / 524130 
umbilical cord0 / 136800 
uterus7 / 23287830
vascular3 / 5178057
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 205474_at
Cell line Expression level Expression bar
721_B_lymphoblasts169.65
Adipocyte11.4
AdrenalCortex13.05
Adrenalgland11.2
Amygdala19.8
Appendix14.05
AtrioventricularNode9.65
BDCA4+_DentriticCells206.8
Bonemarrow65.4
BronchialEpithelialCells29.9
CD105+_Endothelial207
CD14+_Monocytes425.95
CD19+_BCells(neg._sel.)411.5
CD33+_Myeloid320.8
CD34+113.55
CD4+_Tcells574.45
CD56+_NKCells443.1
CD71+_EarlyErythroid459.55
CD8+_Tcells533.5
CardiacMyocytes15.1
Caudatenucleus10.7
Cerebellum10.7
CerebellumPeduncles13.95
CiliaryGanglion9.65
CingulateCortex11.75
Colorectaladenocarcinoma15.05
DorsalRootGanglion10.75
FetalThyroid12.5
Fetalbrain22.75
Fetalliver43.25
Fetallung25.8
GlobusPallidus9.15
Heart15.8
Hypothalamus19.45
Kidney10.1
Leukemia_chronicMyelogenousK-56232
Leukemia_promyelocytic-HL-6088.15
Leukemialymphoblastic(MOLT-4)99.5
Liver17
Lung14.85
Lymphnode169.05
Lymphoma_burkitts(Daudi)75.9
Lymphoma_burkitts(Raji)135.8
MedullaOblongata11.05
OccipitalLobe10.45
OlfactoryBulb11.05
Ovary8.2
Pancreas11
PancreaticIslet14.1
ParietalLobe12.9
Pituitary15.85
Placenta54.6
Pons9.25
PrefrontalCortex16.4
Prostate19.95
Salivarygland31.95
SkeletalMuscle13.65
Skin10.45
SmoothMuscle13.05
Spinalcord16.3
SubthalamicNucleus10.6
SuperiorCervicalGanglion14.55
TemporalLobe10.95
Testis12.85
TestisGermCell17.4
TestisIntersitial13.55
TestisLeydigCell19
TestisSeminiferousTubule22.4
Thalamus11.4
Thymus124.75
Thyroid15.6
Tongue14.45
Tonsil82
Trachea13
TrigeminalGanglion12.05
Uterus20.25
UterusCorpus11.6
WholeBlood965.9
Wholebrain12.75
colon23.2
pineal_day20.9
pineal_night19.86
retina16.55
small_intestine28.55
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P56894
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.26 ± 0.43
Basal Forebrain6.28 ± 0.28
Basal Part of Pons6.05 ± 0.23
Cerebellar Cortex6.35 ± 0.22
Cerebellar Nuclei6.29 ± 0.21
Claustrum6.34 ± 0.38
Epithalamus6.57 ± 0.41
Frontal Lobe5.85 ± 0.44
Globus Pallidus6.48 ± 0.3
Hypothalamus6.45 ± 0.19
Insula5.88 ± 0.42
Limbic Lobe5.83 ± 0.58
Mesencephalon6.2 ± 0.4
Myelencephalon6.08 ± 0.39
Occipital Lobe6.44 ± 0.4
Parietal Lobe6.01 ± 0.42
Pontine Tegmentum6 ± 0.45
Striatum5.69 ± 0.47
Subthalamus6.3 ± 0.21
Temporal Lobe6 ± 0.41
Thalamus6.1 ± 0.23
White Matter6.71 ± 0.2
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Crlf3CBCerebellum38.27
27.26
Crlf3CTXCerebral cortex61.3
38.67
Crlf3HIPHippocampal region47.98
30.71
Crlf3HPFHippocampal formation56.14
38.04
Crlf3HYHypothalamus24.6
13.88
Crlf3LSXLateral septal complex18.36
10.06
Crlf3MBMidbrain20.51
15.04
Crlf3MYMedulla42.46
29.62
Crlf3OLFOlfactory bulb78.06
46.13
Crlf3PPons35.98
24.37
Crlf3PALPallidum22.87
14.77
Crlf3RHPRetrohippocampal region70.44
48.67
Crlf3sAMYStriatum-like amygdalar nuclei27.06
16.1
Crlf3STRStriatum32.85
18.66
Crlf3STRdStriatum dorsal region31.76
17.81
Crlf3STRvStriatum ventral region48.57
27.11
Crlf3THThalamus18.22
10.62
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
CRLF3_HUMAN_173 25 173 197 HGTVASRPPVQIEELIEKPGGIIVR PRIDE
CRLF3_HUMAN_330 18 330 347 DSIGVCAEKQDGYDSLQR PRIDE
CRLF3_HUMAN_73 24 73 96 LVTLLQEVDTIEQETIKPLDDCQK PRIDE
CRLF3_HUMAN_97 14 97 110 LIEHGVNTAEDLVR PRIDE
PAp00033230 18 331 348 DSIGVCAEKQDGYDSLQR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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