AutismKB 2.0

Annotation Detail for EIF3L


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Basic Information Top
Gene Symbol:EIF3L ( EIF3EIP,EIF3S11,EIF3S6IP,HSPC025,MSTP005 )
Gene Full Name: eukaryotic translation initiation factor 3, subunit L
Band: 22q13.1
Quick LinksEntrez ID:51386; OMIM: NA; Uniprot ID:EIF3L_HUMAN; ENSEMBL ID: ENSG00000100129; HGNC ID: 18138
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body24 / 70761339
blastocyst48 / 62319770
fetus641 / 5640121136
neonate65 / 310972090
infant167 / 236207070
juvenile225 / 555564049
adult1443 / 1939121744
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor8 / 12794625
bladder carcinoma7 / 17475400
breast (mammary gland) tumor79 / 94178838
cervical tumor43 / 343661251
chondrosarcoma21 / 82823253
colorectal tumor73 / 114246638
esophageal tumor72 / 172904164
gastrointestinal tumor113 / 119369946
germ cell tumor338 / 2638451281
glioma105 / 106883982
head and neck tumor45 / 136302330
kidney tumor45 / 68959652
leukemia89 / 95842928
liver tumor102 / 963591058
lung tumor56 / 103127543
lymphoma101 / 717551407
non-neoplasia150 / 972501542
normal4116 / 33603071224
ovarian tumor49 / 76682639
pancreatic tumor33 / 104616315
primitive neuroectodermal tumor of the CNS667 / 1256805307
prostate cancer42 / 102680409
retinoblastoma81 / 463561747
skin tumor109 / 124949872
soft tissue/muscle tissue tumor76 / 125191607
uterine tumor56 / 90257620
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue16 / 131061220
adrenal gland97 / 331972921
ascites54 / 400151349
bladder74 / 297572486
blood161 / 1234781303
bone21 / 71655293
bone marrow42 / 48801860
brain1862 / 11009891691
cervix86 / 481711785
connective tissue170 / 1492551138
ear7 / 16212431
embryonic tissue131 / 215722607
esophagus83 / 202094107
eye136 / 211054644
heart146 / 896261628
intestine295 / 2344721258
kidney181 / 211777854
larynx4 / 24145165
liver159 / 207743765
lung234 / 336974694
lymph38 / 44270858
lymph node39 / 91610425
mammary gland127 / 153271828
mouth12 / 67052178
muscle89 / 107715826
nerve7 / 15768443
ovary95 / 102051930
pancreas58 / 214812270
parathyroid1 / 2053948
pharynx21 / 41328508
pituitary gland7 / 16585422
placenta559 / 2808251990
prostate135 / 189345712
salivary gland29 / 201551438
skin161 / 210574764
spleen157 / 539522909
stomach144 / 966191490
testis478 / 3304421446
thymus322 / 811313968
thyroid34 / 47473716
tonsil20 / 169991176
trachea36 / 52413686
umbilical cord37 / 136802704
uterus304 / 2328781305
vascular63 / 517801216
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 217719_at
Cell line Expression level Expression bar
721_B_lymphoblasts3785.45
Adipocyte1407.3
AdrenalCortex1468.05
Adrenalgland1034.85
Amygdala1029.65
Appendix784.1
AtrioventricularNode316.75
BDCA4+_DentriticCells4230.95
Bonemarrow1033
BronchialEpithelialCells3084.15
CD105+_Endothelial3690.7
CD14+_Monocytes3645.1
CD19+_BCells(neg._sel.)3750.15
CD33+_Myeloid4527.35
CD34+5560.75
CD4+_Tcells3220
CD56+_NKCells3418.95
CD71+_EarlyErythroid1155.25
CD8+_Tcells3141.15
CardiacMyocytes1066.1
Caudatenucleus1225.1
Cerebellum676.55
CerebellumPeduncles1274.45
CiliaryGanglion289.05
CingulateCortex617.2
Colorectaladenocarcinoma952.2
DorsalRootGanglion274.15
FetalThyroid2937.45
Fetalbrain3445.05
Fetalliver1137.85
Fetallung1747.75
GlobusPallidus521.35
Heart657.65
Hypothalamus1292
Kidney828.5
Leukemia_chronicMyelogenousK-5622449.2
Leukemia_promyelocytic-HL-602889.25
Leukemialymphoblastic(MOLT-4)3054.2
Liver1134.45
Lung1512.8
Lymphnode2333.35
Lymphoma_burkitts(Daudi)4747.7
Lymphoma_burkitts(Raji)3874.3
MedullaOblongata704.15
OccipitalLobe791.9
OlfactoryBulb794.7
Ovary1710.05
Pancreas1594.6
PancreaticIslet2751.8
ParietalLobe621.8
Pituitary2647.5
Placenta1558.1
Pons500.15
PrefrontalCortex1395.4
Prostate2092.25
Salivarygland1897.9
SkeletalMuscle288.9
Skin887.95
SmoothMuscle2237.1
Spinalcord1433.3
SubthalamicNucleus635.1
SuperiorCervicalGanglion311.35
TemporalLobe601.65
Testis1856.5
TestisGermCell1424.55
TestisIntersitial992.75
TestisLeydigCell928
TestisSeminiferousTubule939.35
Thalamus895.5
Thymus2098.7
Thyroid3732.9
Tongue1341.8
Tonsil1574.3
Trachea1094.95
TrigeminalGanglion299.7
Uterus2625.85
UterusCorpus628.6
WholeBlood1959.45
Wholebrain738.45
colon1839.8
pineal_day1404.58
pineal_night1503.82
retina1820.15
small_intestine2800.65
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P57521
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala8.57 ± 0.36
Basal Forebrain8.66 ± 0.35
Basal Part of Pons8.88 ± 0.39
Cerebellar Cortex8.86 ± 0.3
Cerebellar Nuclei8.56 ± 0.32
Claustrum8.22 ± 0.64
Epithalamus8.68 ± 0.32
Frontal Lobe8.44 ± 0.34
Globus Pallidus8.24 ± 0.33
Hypothalamus8.7 ± 0.43
Insula8.57 ± 0.28
Limbic Lobe8.2 ± 0.51
Mesencephalon8.3 ± 0.42
Myelencephalon8.36 ± 0.49
Occipital Lobe8.03 ± 0.57
Parietal Lobe8.42 ± 0.37
Pontine Tegmentum8.38 ± 0.33
Striatum8.57 ± 0.53
Subthalamus8.56 ± 0.15
Temporal Lobe8.52 ± 0.34
Thalamus8.16 ± 0.37
White Matter8.12 ± 0.43
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Eif3s6ipCBCerebellum39.12
57.14
Eif3s6ipCTXCerebral cortex100
100
Eif3s6ipHIPHippocampal region88.28
100
Eif3s6ipHPFHippocampal formation94.52
100
Eif3s6ipHYHypothalamus70.07
62.48
Eif3s6ipLSXLateral septal complex81.53
69.48
Eif3s6ipMBMidbrain68.01
67.46
Eif3s6ipMYMedulla58.21
61.56
Eif3s6ipOLFOlfactory bulb81.71
76.86
Eif3s6ipPPons69.28
75.32
Eif3s6ipPALPallidum63.5
65.78
Eif3s6ipRHPRetrohippocampal region100
99.49
Eif3s6ipsAMYStriatum-like amygdalar nuclei70.65
62.82
Eif3s6ipSTRStriatum84.77
70.51
Eif3s6ipSTRdStriatum dorsal region87.8
74
Eif3s6ipSTRvStriatum ventral region84.45
63.92
Eif3s6ipTHThalamus94.51
98.41
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
EIF3L_HUMAN_0 0 0 0 LAGFLDLTEQEFR PRIDE
EIF3L_HUMAN_220 17 220 236 IWNVHSVLNVLHSLVDK PRIDE
EIF3L_HUMAN_226 17 226 242 SVLNVLHSLVDKSNINR PRIDE
EIF3L_HUMAN_243 20 243 262 QLEVYTSGGDPESVAGEYGR PRIDE
EIF3L_HUMAN_30 9 30 38 PKQDLAYER PRIDE
EIF3L_HUMAN_39 15 39 53 QYEQQTYQVIPEVIK PRIDE
EIF3L_HUMAN_474 13 474 486 LAGFLDLTEQEFR PRIDE
EIF3L_HUMAN_546 10 546 555 QIHKFEELNR PRIDE
PAp00002751 16 447 462 GDPQVYEELFSYSCPK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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