AutismKB 2.0

Annotation Detail for PPME1


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Basic Information Top
Gene Symbol:PPME1 ( FLJ22226,PME-1 )
Gene Full Name: protein phosphatase methylesterase 1
Band: 11q13.4
Quick LinksEntrez ID:51400; OMIM: 611117; Uniprot ID:PPME1_HUMAN; ENSEMBL ID: ENSG00000214517; HGNC ID: 30178
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body9 / 70761127
blastocyst5 / 6231980
fetus124 / 564012219
neonate3 / 3109796
infant3 / 23620127
juvenile16 / 55556287
adult173 / 193912189
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor25 / 94178265
cervical tumor9 / 34366261
chondrosarcoma3 / 8282336
colorectal tumor10 / 11424687
esophageal tumor7 / 17290404
gastrointestinal tumor24 / 119369201
germ cell tumor52 / 263845197
glioma14 / 106883130
head and neck tumor20 / 136302146
kidney tumor12 / 68959174
leukemia8 / 9584283
liver tumor9 / 9635993
lung tumor13 / 103127126
lymphoma6 / 7175583
non-neoplasia4 / 9725041
normal568 / 3360307169
ovarian tumor11 / 76682143
pancreatic tumor9 / 10461686
primitive neuroectodermal tumor of the CNS35 / 125680278
prostate cancer2 / 10268019
retinoblastoma7 / 46356151
skin tumor11 / 12494988
soft tissue/muscle tissue tumor9 / 12519171
uterine tumor5 / 9025755
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland3 / 3319790
ascites5 / 40015124
bladder0 / 297570 
blood8 / 12347864
bone2 / 7165527
bone marrow6 / 48801122
brain319 / 1100989289
cervix11 / 48171228
connective tissue9 / 14925560
ear0 / 162120 
embryonic tissue19 / 21572288
esophagus7 / 20209346
eye26 / 211054123
heart6 / 8962666
intestine20 / 23447285
kidney106 / 211777500
larynx0 / 241450 
liver15 / 20774372
lung42 / 336974124
lymph4 / 4427090
lymph node0 / 916100 
mammary gland30 / 153271195
mouth17 / 67052253
muscle2 / 10771518
nerve1 / 1576863
ovary12 / 102051117
pancreas16 / 21481274
parathyroid1 / 2053948
pharynx2 / 4132848
pituitary gland0 / 165850 
placenta17 / 28082560
prostate14 / 18934573
salivary gland2 / 2015599
skin45 / 210574213
spleen3 / 5395255
stomach34 / 96619351
testis50 / 330442151
thymus11 / 81131135
thyroid7 / 47473147
tonsil0 / 169990 
trachea5 / 5241395
umbilical cord0 / 136800 
uterus20 / 23287885
vascular7 / 51780135
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 217841_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts61.55
Adipocyte19.3
AdrenalCortex23.5
Adrenalgland30.65
Amygdala95.95
Appendix9.4
AtrioventricularNode15.7
BDCA4+_DentriticCells19.15
Bonemarrow24.2
BronchialEpithelialCells44.05
CD105+_Endothelial87.75
CD14+_Monocytes13.5
CD19+_BCells(neg._sel.)15.4
CD33+_Myeloid25.75
CD34+38.5
CD4+_Tcells15.5
CD56+_NKCells21.85
CD71+_EarlyErythroid471.25
CD8+_Tcells18.3
CardiacMyocytes33.45
Caudatenucleus66.85
Cerebellum47.65
CerebellumPeduncles59.15
CiliaryGanglion13.35
CingulateCortex70.05
Colorectaladenocarcinoma613.15
DorsalRootGanglion17.55
FetalThyroid31.75
Fetalbrain47.45
Fetalliver50.45
Fetallung37.4
GlobusPallidus30
Heart21.65
Hypothalamus67.95
Kidney20.4
Leukemia_chronicMyelogenousK-56251.85
Leukemia_promyelocytic-HL-6024
Leukemialymphoblastic(MOLT-4)28.7
Liver28.95
Lung42.85
Lymphnode12.85
Lymphoma_burkitts(Daudi)32.3
Lymphoma_burkitts(Raji)56.8
MedullaOblongata41.05
OccipitalLobe64.1
OlfactoryBulb21.8
Ovary18.5
Pancreas15.9
PancreaticIslet36.15
ParietalLobe67.7
Pituitary36.15
Placenta57.15
Pons35.45
PrefrontalCortex146
Prostate62.6
Salivarygland19.4
SkeletalMuscle31.2
Skin20.5
SmoothMuscle48.5
Spinalcord34.65
SubthalamicNucleus53.15
SuperiorCervicalGanglion29.7
TemporalLobe35.9
Testis55.75
TestisGermCell48
TestisIntersitial25.75
TestisLeydigCell32.4
TestisSeminiferousTubule42.6
Thalamus48.3
Thymus17.55
Thyroid45.55
Tongue24.55
Tonsil17.75
Trachea21.95
TrigeminalGanglion13.15
Uterus28.95
UterusCorpus22.55
WholeBlood13.4
Wholebrain221.65
colon11.35
pineal_day110.98
pineal_night108.4
retina32.1
small_intestine18.5
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P4705
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala9.17 ± 0.51
Basal Forebrain9.05 ± 0.38
Basal Part of Pons9.55 ± 0.25
Cerebellar Cortex9.02 ± 0.24
Cerebellar Nuclei9.19 ± 0.43
Claustrum9.57 ± 0.49
Epithalamus8.92 ± 0.27
Frontal Lobe9.27 ± 0.41
Globus Pallidus8.4 ± 0.51
Hypothalamus9.23 ± 0.57
Insula9.24 ± 0.24
Limbic Lobe9.49 ± 0.48
Mesencephalon9.27 ± 0.49
Myelencephalon9.24 ± 0.44
Occipital Lobe9.68 ± 0.34
Parietal Lobe9.44 ± 0.39
Pontine Tegmentum9.3 ± 0.38
Striatum9.27 ± 0.43
Subthalamus9.45 ± 0.3
Temporal Lobe9.38 ± 0.34
Thalamus9.27 ± 0.23
White Matter8.45 ± 0.48
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Ppme1CBCerebellum48.2
75.79
Ppme1CTXCerebral cortex100
100
Ppme1HIPHippocampal region100
100
Ppme1HPFHippocampal formation100
100
Ppme1HYHypothalamus90.89
88.83
Ppme1LSXLateral septal complex74.96
70.92
Ppme1MBMidbrain77.64
84.82
Ppme1MYMedulla64.92
77.63
Ppme1OLFOlfactory bulb99.88
100
Ppme1PPons73.55
90.76
Ppme1PALPallidum88
98.02
Ppme1RHPRetrohippocampal region100
100
Ppme1sAMYStriatum-like amygdalar nuclei100
100
Ppme1STRStriatum97.16
84.52
Ppme1STRdStriatum dorsal region98.21
84.84
Ppme1STRvStriatum ventral region96.39
79.18
Ppme1THThalamus100
100
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00010249 13 304 316 GLSNLFLSCPIPK Peptide Atlas
PPME1_HUMAN_1 11 1 11 SALEKSMHLGR PRIDE
PPME1_HUMAN_2 11 2 12 SALEKSMHLGR PRIDE
PPME1_HUMAN_206 11 206 216 SLENAIEWSVK PRIDE
PPME1_HUMAN_24 8 24 31 SQSGAKMR PRIDE
PPME1_HUMAN_25 8 25 32 SQSGAKMR PRIDE
PPME1_HUMAN_303 13 303 315 GLSNLFLSCPIPK PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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