AutismKB 2.0

Annotation Detail for PDE4A


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Basic Information Top
Gene Symbol:PDE4A ( DPDE2,PDE4,PDE46 )
Gene Full Name: phosphodiesterase 4A, cAMP-specific
Band: 19p13.2
Quick LinksEntrez ID:5141; OMIM: 600126; Uniprot ID:PDE4A_HUMAN; ENSEMBL ID: ENSG00000065989; HGNC ID: 8780
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst3 / 6231948
fetus10 / 56401217
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult31 / 193912115
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma1 / 8282312
colorectal tumor3 / 11424626
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor2 / 2638457
glioma6 / 10688356
head and neck tumor3 / 13630222
kidney tumor1 / 6895914
leukemia0 / 958420 
liver tumor3 / 9635931
lung tumor4 / 10312738
lymphoma0 / 717550 
non-neoplasia1 / 9725010
normal42 / 336030712
ovarian tumor4 / 7668252
pancreatic tumor2 / 10461619
primitive neuroectodermal tumor of the CNS1 / 1256807
prostate cancer4 / 10268038
retinoblastoma2 / 4635643
skin tumor1 / 1249498
soft tissue/muscle tissue tumor5 / 12519139
uterine tumor2 / 9025722
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood3 / 12347824
bone1 / 7165513
bone marrow0 / 488010 
brain18 / 110098916
cervix0 / 481710 
connective tissue2 / 14925513
ear0 / 162120 
embryonic tissue3 / 21572213
esophagus0 / 202090 
eye4 / 21105418
heart0 / 896260 
intestine5 / 23447221
kidney1 / 2117774
larynx1 / 2414541
liver3 / 20774314
lung6 / 33697417
lymph0 / 442700 
lymph node0 / 916100 
mammary gland2 / 15327113
mouth0 / 670520 
muscle3 / 10771527
nerve0 / 157680 
ovary4 / 10205139
pancreas8 / 21481237
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta1 / 2808253
prostate5 / 18934526
salivary gland2 / 2015599
skin2 / 2105749
spleen1 / 5395218
stomach0 / 966190 
testis1 / 3304423
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus7 / 23287830
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 204735_at
Cell line Expression level Expression bar
721_B_lymphoblasts6.95
Adipocyte6.05
AdrenalCortex5.7
Adrenalgland4.8
Amygdala36.35
Appendix4.85
AtrioventricularNode3.9
BDCA4+_DentriticCells6.5
Bonemarrow4.6
BronchialEpithelialCells4.45
CD105+_Endothelial4.45
CD14+_Monocytes8.65
CD19+_BCells(neg._sel.)4.85
CD33+_Myeloid9.7
CD34+5.55
CD4+_Tcells6.2
CD56+_NKCells35.55
CD71+_EarlyErythroid4
CD8+_Tcells5.5
CardiacMyocytes6.1
Caudatenucleus11.45
Cerebellum18.55
CerebellumPeduncles11.8
CiliaryGanglion3.5
CingulateCortex21.35
Colorectaladenocarcinoma13.4
DorsalRootGanglion3.5
FetalThyroid21.95
Fetalbrain27.25
Fetalliver3.95
Fetallung4.7
GlobusPallidus13.25
Heart6.45
Hypothalamus33.8
Kidney3.9
Leukemia_chronicMyelogenousK-56224.9
Leukemia_promyelocytic-HL-607.35
Leukemialymphoblastic(MOLT-4)3.8
Liver7
Lung39.55
Lymphnode4.9
Lymphoma_burkitts(Daudi)6.1
Lymphoma_burkitts(Raji)7.65
MedullaOblongata20.7
OccipitalLobe18.9
OlfactoryBulb4
Ovary3
Pancreas4.5
PancreaticIslet5.75
ParietalLobe15.4
Pituitary5.25
Placenta5.2
Pons12.5
PrefrontalCortex126.85
Prostate11.5
Salivarygland4.5
SkeletalMuscle5.3
Skin4.05
SmoothMuscle5.85
Spinalcord6.3
SubthalamicNucleus17.1
SuperiorCervicalGanglion5.15
TemporalLobe17.85
Testis9.5
TestisGermCell4.25
TestisIntersitial4.1
TestisLeydigCell5.05
TestisSeminiferousTubule4.75
Thalamus34.55
Thymus3.9
Thyroid23
Tongue4.9
Tonsil4.4
Trachea5
TrigeminalGanglion5.15
Uterus5.95
UterusCorpus4.45
WholeBlood5.85
Wholebrain45.2
colon5.3
pineal_day42.62
pineal_night110.9
retina15.575
small_intestine4.85
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P208334
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.61 ± 0.82
Basal Forebrain1.97 ± 0.27
Basal Part of Pons3.2 ± 0.53
Cerebellar Cortex2.39 ± 0.73
Cerebellar Nuclei2.43 ± 0.65
Claustrum2.53 ± 0.67
Epithalamus2.12 ± 0.67
Frontal Lobe2.39 ± 0.75
Globus Pallidus1.94 ± 0.77
Hypothalamus2.24 ± 0.43
Insula2.25 ± 0.65
Limbic Lobe2.59 ± 0.65
Mesencephalon2.38 ± 0.72
Myelencephalon2.41 ± 0.67
Occipital Lobe2.81 ± 0.45
Parietal Lobe2.69 ± 0.65
Pontine Tegmentum2.35 ± 0.74
Striatum1.95 ± 0.92
Subthalamus2.37 ± 0.78
Temporal Lobe2.42 ± 0.67
Thalamus2.62 ± 0.68
White Matter1.37 ± 0.63
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Pde4aCBCerebellum7.27
7.46
Pde4aCTXCerebral cortex49.83
38.88
Pde4aHIPHippocampal region38.29
30.42
Pde4aHPFHippocampal formation50.85
40.89
Pde4aHYHypothalamus11.45
8.71
Pde4aLSXLateral septal complex8.79
5.66
Pde4aMBMidbrain15.65
13.44
Pde4aMYMedulla23.54
23.18
Pde4aOLFOlfactory bulb70.94
50.49
Pde4aPPons22.53
21.45
Pde4aPALPallidum21.24
20.38
Pde4aRHPRetrohippocampal region64.53
58.99
Pde4asAMYStriatum-like amygdalar nuclei27.56
13.1
Pde4aSTRStriatum8.69
5.96
Pde4aSTRdStriatum dorsal region6.05
4.29
Pde4aSTRvStriatum ventral region11.7
7.1
Pde4aTHThalamus8.93
7.18
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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