AutismKB 2.0

Annotation Detail for PDE4B


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Basic Information Top
Gene Symbol:PDE4B ( DKFZp686F2182,DPDE4,MGC126529,PDE4B5,PDEIVB )
Gene Full Name: phosphodiesterase 4B, cAMP-specific
Band: 1p31.3
Quick LinksEntrez ID:5142; OMIM: 600127; Uniprot ID:PDE4B_HUMAN; ENSEMBL ID: ENSG00000184588; HGNC ID: 8781
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst1 / 6231916
fetus37 / 56401265
neonate1 / 3109732
infant0 / 236200 
juvenile0 / 555560 
adult111 / 193912157
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma2 / 17475114
breast (mammary gland) tumor3 / 9417831
cervical tumor0 / 343660 
chondrosarcoma2 / 8282324
colorectal tumor3 / 11424626
esophageal tumor0 / 172900 
gastrointestinal tumor3 / 11936925
germ cell tumor21 / 26384579
glioma5 / 10688346
head and neck tumor9 / 13630266
kidney tumor1 / 6895914
leukemia3 / 9584231
liver tumor1 / 9635910
lung tumor3 / 10312729
lymphoma0 / 717550 
non-neoplasia9 / 9725092
normal291 / 336030786
ovarian tumor0 / 766820 
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer2 / 10268019
retinoblastoma0 / 463560 
skin tumor2 / 12494916
soft tissue/muscle tissue tumor6 / 12519147
uterine tumor2 / 9025722
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland0 / 331970 
ascites2 / 4001549
bladder2 / 2975767
blood10 / 12347880
bone2 / 7165527
bone marrow0 / 488010 
brain204 / 1100989185
cervix0 / 481710 
connective tissue14 / 14925593
ear0 / 162120 
embryonic tissue3 / 21572213
esophagus0 / 202090 
eye3 / 21105414
heart4 / 8962644
intestine5 / 23447221
kidney2 / 2117779
larynx0 / 241450 
liver1 / 2077434
lung9 / 33697426
lymph0 / 442700 
lymph node7 / 9161076
mammary gland9 / 15327158
mouth2 / 6705229
muscle5 / 10771546
nerve0 / 157680 
ovary0 / 1020510 
pancreas3 / 21481213
parathyroid0 / 205390 
pharynx4 / 4132896
pituitary gland0 / 165850 
placenta7 / 28082524
prostate8 / 18934542
salivary gland0 / 201550 
skin5 / 21057423
spleen0 / 539520 
stomach2 / 9661920
testis39 / 330442118
thymus7 / 8113186
thyroid8 / 47473168
tonsil0 / 169990 
trachea15 / 52413286
umbilical cord1 / 1368073
uterus4 / 23287817
vascular5 / 5178096
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 211302_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts6.85
Adipocyte5.5
AdrenalCortex6.15
Adrenalgland4.95
Amygdala7.55
Appendix6.7
AtrioventricularNode4.9
BDCA4+_DentriticCells56.3
Bonemarrow5.75
BronchialEpithelialCells5.15
CD105+_Endothelial6.05
CD14+_Monocytes8.6
CD19+_BCells(neg._sel.)93.85
CD33+_Myeloid11
CD34+7.15
CD4+_Tcells50.25
CD56+_NKCells6.65
CD71+_EarlyErythroid5.35
CD8+_Tcells32.15
CardiacMyocytes7.7
Caudatenucleus9.05
Cerebellum7.3
CerebellumPeduncles6.7
CiliaryGanglion4.4
CingulateCortex8.75
Colorectaladenocarcinoma6
DorsalRootGanglion4.55
FetalThyroid5.8
Fetalbrain6.2
Fetalliver5.15
Fetallung13.25
GlobusPallidus6.65
Heart7.45
Hypothalamus13.7
Kidney4.75
Leukemia_chronicMyelogenousK-5625.1
Leukemia_promyelocytic-HL-605
Leukemialymphoblastic(MOLT-4)4.25
Liver7.65
Lung6.6
Lymphnode6.1
Lymphoma_burkitts(Daudi)7.25
Lymphoma_burkitts(Raji)8.25
MedullaOblongata6.4
OccipitalLobe21.75
OlfactoryBulb4.75
Ovary3.95
Pancreas4.75
PancreaticIslet6.3
ParietalLobe11.35
Pituitary6.95
Placenta5.95
Pons8.85
PrefrontalCortex20.9
Prostate6.55
Salivarygland4.75
SkeletalMuscle15.75
Skin5.25
SmoothMuscle7.35
Spinalcord10
SubthalamicNucleus6.15
SuperiorCervicalGanglion6.7
TemporalLobe5.45
Testis5.1
TestisGermCell5
TestisIntersitial4.95
TestisLeydigCell5.9
TestisSeminiferousTubule5.15
Thalamus6.7
Thymus4.45
Thyroid7.5
Tongue5.75
Tonsil8.3
Trachea8.3
TrigeminalGanglion8.2
Uterus4.9
UterusCorpus5.3
WholeBlood24.4
Wholebrain10.65
colon6.05
pineal_day7.64
pineal_night8.28
retina13.5
small_intestine6.95
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P921129
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.42 ± 1.03
Basal Forebrain2.66 ± 0.43
Basal Part of Pons2.54 ± 0.28
Cerebellar Cortex2.73 ± 0.59
Cerebellar Nuclei3.21 ± 0.65
Claustrum3.11 ± 0.65
Epithalamus2.76 ± 0.97
Frontal Lobe2.81 ± 0.75
Globus Pallidus4.05 ± 0.49
Hypothalamus2.7 ± 0.59
Insula2.33 ± 0.85
Limbic Lobe2.78 ± 0.67
Mesencephalon3.25 ± 0.71
Myelencephalon2.91 ± 0.74
Occipital Lobe2.99 ± 0.78
Parietal Lobe2.87 ± 0.72
Pontine Tegmentum3.01 ± 0.81
Striatum3.29 ± 0.67
Subthalamus3.41 ± 0.24
Temporal Lobe2.74 ± 0.7
Thalamus3.07 ± 0.58
White Matter5.25 ± 0.15
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Pde4bCBCerebellum5.24
3.95
Pde4bCTXCerebral cortex16.79
8.31
Pde4bHIPHippocampal region16.82
9.27
Pde4bHPFHippocampal formation16.64
9.54
Pde4bHYHypothalamus8.86
4.64
Pde4bLSXLateral septal complex15.78
7.9
Pde4bMBMidbrain7.41
4.43
Pde4bMYMedulla9.56
5.89
Pde4bOLFOlfactory bulb30.94
17.43
Pde4bPPons6.53
3.88
Pde4bPALPallidum7.03
4.17
Pde4bRHPRetrohippocampal region17.59
10.95
Pde4bsAMYStriatum-like amygdalar nuclei7.19
3.73
Pde4bSTRStriatum17.66
8.88
Pde4bSTRdStriatum dorsal region15.46
7.93
Pde4bSTRvStriatum ventral region32.58
15.02
Pde4bTHThalamus5.58
2.91
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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