AutismKB 2.0

Annotation Detail for POLK


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:POLK ( DINB1,DINP,POLQ )
Gene Full Name: polymerase (DNA directed) kappa
Band: 5q13.3
Quick LinksEntrez ID:51426; OMIM: 605650; Uniprot ID:POLK_HUMAN; ENSEMBL ID: ENSG00000122008; HGNC ID: 9183
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body3 / 7076142
blastocyst0 / 623190 
fetus27 / 56401247
neonate1 / 3109732
infant0 / 236200 
juvenile0 / 555560 
adult51 / 193912126
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor3 / 9417831
cervical tumor2 / 3436658
chondrosarcoma1 / 8282312
colorectal tumor1 / 1142468
esophageal tumor0 / 172900 
gastrointestinal tumor2 / 11936916
germ cell tumor9 / 26384534
glioma1 / 1068839
head and neck tumor5 / 13630236
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor2 / 9635920
lung tumor2 / 10312719
lymphoma2 / 7175527
non-neoplasia5 / 9725051
normal116 / 336030734
ovarian tumor1 / 7668213
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer4 / 10268038
retinoblastoma0 / 463560 
skin tumor2 / 12494916
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor4 / 9025744
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland2 / 3319760
ascites0 / 400150 
bladder1 / 2975733
blood1 / 1234788
bone2 / 7165527
bone marrow0 / 488010 
brain54 / 110098949
cervix2 / 4817141
connective tissue3 / 14925520
ear0 / 162120 
embryonic tissue3 / 21572213
esophagus0 / 202090 
eye5 / 21105423
heart2 / 8962622
intestine5 / 23447221
kidney3 / 21177714
larynx0 / 241450 
liver6 / 20774328
lung15 / 33697444
lymph1 / 4427022
lymph node1 / 9161010
mammary gland5 / 15327132
mouth3 / 6705244
muscle6 / 10771555
nerve0 / 157680 
ovary1 / 1020519
pancreas3 / 21481213
parathyroid2 / 2053997
pharynx2 / 4132848
pituitary gland3 / 16585180
placenta5 / 28082517
prostate5 / 18934526
salivary gland0 / 201550 
skin3 / 21057414
spleen1 / 5395218
stomach2 / 9661920
testis13 / 33044239
thymus2 / 8113124
thyroid3 / 4747363
tonsil0 / 169990 
trachea7 / 52413133
umbilical cord0 / 136800 
uterus9 / 23287838
vascular6 / 51780115
Microarray in BioGPS Top
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P303160
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.79 ± 0.31
Basal Forebrain6.96 ± 0.19
Basal Part of Pons6.57 ± 0.31
Cerebellar Cortex6.9 ± 0.27
Cerebellar Nuclei7.07 ± 0.29
Claustrum6.92 ± 0.22
Epithalamus7.04 ± 0.28
Frontal Lobe6.68 ± 0.3
Globus Pallidus7.28 ± 0.32
Hypothalamus6.85 ± 0.24
Insula6.71 ± 0.17
Limbic Lobe6.77 ± 0.29
Mesencephalon6.81 ± 0.36
Myelencephalon6.79 ± 0.33
Occipital Lobe7.14 ± 0.34
Parietal Lobe6.74 ± 0.29
Pontine Tegmentum6.89 ± 0.31
Striatum7.03 ± 0.34
Subthalamus6.8 ± 0.08
Temporal Lobe6.68 ± 0.23
Thalamus6.79 ± 0.29
White Matter7.95 ± 0.14
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
PolkCBCerebellum48.55
56.63
PolkCTXCerebral cortex34.54
21.42
PolkHIPHippocampal region5.38
4.31
PolkHPFHippocampal formation26.43
21.84
PolkHYHypothalamus37.29
21.37
PolkLSXLateral septal complex76
49.21
PolkMBMidbrain37.54
25.23
PolkMYMedulla44.84
36.4
PolkOLFOlfactory bulb77.78
56.37
PolkPPons32.07
24.37
PolkPALPallidum40.15
28.58
PolkRHPRetrohippocampal region52.86
40.68
PolksAMYStriatum-like amygdalar nuclei80.97
56.1
PolkSTRStriatum20.15
13.06
PolkSTRdStriatum dorsal region5.98
4.13
PolkSTRvStriatum ventral region17.88
10.35
PolkTHThalamus48.44
29.88
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
POLK_HUMAN_764 23 764 786 QPYLCEVKTGQALVCPVCNVEQK PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018