AutismKB 2.0

Annotation Detail for LCMT1


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Basic Information Top
Gene Symbol:LCMT1 ( LCMT,PPMT1 )
Gene Full Name: leucine carboxyl methyltransferase 1
Band: 16p12.1
Quick LinksEntrez ID:51451; OMIM: 610286; Uniprot ID:LCMT1_HUMAN; ENSEMBL ID: ENSG00000205629; HGNC ID: 17557
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst3 / 6231948
fetus23 / 56401240
neonate2 / 3109764
infant1 / 2362042
juvenile1 / 5555617
adult79 / 193912140
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor3 / 12794234
bladder carcinoma1 / 1747557
breast (mammary gland) tumor6 / 9417863
cervical tumor3 / 3436687
chondrosarcoma5 / 8282360
colorectal tumor4 / 11424635
esophageal tumor0 / 172900 
gastrointestinal tumor3 / 11936925
germ cell tumor8 / 26384530
glioma8 / 10688374
head and neck tumor4 / 13630229
kidney tumor5 / 6895972
leukemia14 / 95842146
liver tumor4 / 9635941
lung tumor7 / 10312767
lymphoma4 / 7175555
non-neoplasia2 / 9725020
normal155 / 336030746
ovarian tumor5 / 7668265
pancreatic tumor12 / 104616114
primitive neuroectodermal tumor of the CNS8 / 12568063
prostate cancer0 / 1026800 
retinoblastoma2 / 4635643
skin tumor4 / 12494932
soft tissue/muscle tissue tumor8 / 12519163
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue3 / 13106228
adrenal gland3 / 3319790
ascites1 / 4001524
bladder2 / 2975767
blood10 / 12347880
bone4 / 7165555
bone marrow3 / 4880161
brain51 / 110098946
cervix3 / 4817162
connective tissue11 / 14925573
ear1 / 1621261
embryonic tissue7 / 21572232
esophagus0 / 202090 
eye13 / 21105461
heart9 / 89626100
intestine12 / 23447251
kidney12 / 21177756
larynx0 / 241450 
liver10 / 20774348
lung14 / 33697441
lymph1 / 4427022
lymph node5 / 9161054
mammary gland9 / 15327158
mouth0 / 670520 
muscle5 / 10771546
nerve1 / 1576863
ovary6 / 10205158
pancreas17 / 21481279
parathyroid0 / 205390 
pharynx5 / 41328120
pituitary gland3 / 16585180
placenta11 / 28082539
prostate4 / 18934521
salivary gland0 / 201550 
skin8 / 21057437
spleen0 / 539520 
stomach2 / 9661920
testis18 / 33044254
thymus2 / 8113124
thyroid2 / 4747342
tonsil1 / 1699958
trachea1 / 5241319
umbilical cord2 / 13680146
uterus5 / 23287821
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 221515_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts69.7
Adipocyte46.9
AdrenalCortex51.25
Adrenalgland48.8
Amygdala84.9
Appendix50.6
AtrioventricularNode36.45
BDCA4+_DentriticCells69.45
Bonemarrow47.55
BronchialEpithelialCells77.35
CD105+_Endothelial56.75
CD14+_Monocytes73.5
CD19+_BCells(neg._sel.)64.35
CD33+_Myeloid70.4
CD34+117.9
CD4+_Tcells94.55
CD56+_NKCells135.4
CD71+_EarlyErythroid38.8
CD8+_Tcells79.45
CardiacMyocytes62.95
Caudatenucleus62.65
Cerebellum60.35
CerebellumPeduncles67.8
CiliaryGanglion31.7
CingulateCortex95.7
Colorectaladenocarcinoma50.55
DorsalRootGanglion32
FetalThyroid54.95
Fetalbrain56.05
Fetalliver43.75
Fetallung40.65
GlobusPallidus46.35
Heart119.4
Hypothalamus139.95
Kidney40.5
Leukemia_chronicMyelogenousK-56281.15
Leukemia_promyelocytic-HL-6050.7
Leukemialymphoblastic(MOLT-4)62.65
Liver64.95
Lung88.85
Lymphnode44.65
Lymphoma_burkitts(Daudi)55.85
Lymphoma_burkitts(Raji)77.1
MedullaOblongata61.75
OccipitalLobe71.6
OlfactoryBulb34.35
Ovary33.45
Pancreas40.85
PancreaticIslet96.9
ParietalLobe52.9
Pituitary66.05
Placenta53.6
Pons49.75
PrefrontalCortex136.9
Prostate122.8
Salivarygland36.45
SkeletalMuscle55.7
Skin37.95
SmoothMuscle53.95
Spinalcord44.6
SubthalamicNucleus58.4
SuperiorCervicalGanglion45.85
TemporalLobe63.1
Testis194.05
TestisGermCell132.35
TestisIntersitial71.55
TestisLeydigCell69.4
TestisSeminiferousTubule104.45
Thalamus60.65
Thymus66.9
Thyroid65.85
Tongue46.65
Tonsil43.05
Trachea33.95
TrigeminalGanglion41.05
Uterus44.95
UterusCorpus42.6
WholeBlood56.35
Wholebrain210.5
colon45.6
pineal_day136.72
pineal_night143.24
retina58.825
small_intestine41.5
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_6081_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala8.11 ± 0.53
Basal Forebrain8.09 ± 0.23
Basal Part of Pons8.64 ± 0.32
Cerebellar Cortex8.52 ± 0.27
Cerebellar Nuclei8.25 ± 0.38
Claustrum8.19 ± 0.51
Epithalamus7.98 ± 0.3
Frontal Lobe8.42 ± 0.33
Globus Pallidus7.51 ± 0.23
Hypothalamus8.71 ± 0.32
Insula8.56 ± 0.24
Limbic Lobe8.1 ± 0.48
Mesencephalon8.11 ± 0.34
Myelencephalon8.17 ± 0.5
Occipital Lobe7.7 ± 0.57
Parietal Lobe8.21 ± 0.38
Pontine Tegmentum8.21 ± 0.38
Striatum7.67 ± 0.47
Subthalamus8.37 ± 0.18
Temporal Lobe8.42 ± 0.35
Thalamus8.02 ± 0.36
White Matter7.69 ± 0.27
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Lcmt1CBCerebellum10.86
10.55
Lcmt1CTXCerebral cortex55.91
33.4
Lcmt1HIPHippocampal region41.77
57.51
Lcmt1HPFHippocampal formation46.44
49.76
Lcmt1HYHypothalamus17.45
11.14
Lcmt1LSXLateral septal complex12.27
5.74
Lcmt1MBMidbrain12.49
8
Lcmt1MYMedulla25.89
20.47
Lcmt1OLFOlfactory bulb43.76
31.37
Lcmt1PPons21.83
17.72
Lcmt1PALPallidum26.91
18.74
Lcmt1RHPRetrohippocampal region59.92
40.1
Lcmt1sAMYStriatum-like amygdalar nuclei85.39
53.33
Lcmt1STRStriatum46.68
25.31
Lcmt1STRdStriatum dorsal region43.59
22.31
Lcmt1STRvStriatum ventral region58.65
31.46
Lcmt1THThalamus10.49
7.15
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00561028 18 241 258 IESLEFLDEMELLEQLMR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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