AutismKB 2.0

Annotation Detail for LIMA1


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Basic Information Top
Gene Symbol:LIMA1 ( EPLIN,FLJ38853,MGC131726,SREBP3 )
Gene Full Name: LIM domain and actin binding 1
Band: 12q13.12
Quick LinksEntrez ID:51474; OMIM: 608364; Uniprot ID:LIMA1_HUMAN; ENSEMBL ID: ENSG00000050405; HGNC ID: 24636
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body8 / 70761113
blastocyst5 / 6231980
fetus32 / 56401256
neonate11 / 31097353
infant1 / 2362042
juvenile6 / 55556107
adult201 / 1939121103
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma2 / 17475114
breast (mammary gland) tumor4 / 9417842
cervical tumor1 / 3436629
chondrosarcoma13 / 82823156
colorectal tumor23 / 114246201
esophageal tumor6 / 17290347
gastrointestinal tumor13 / 119369108
germ cell tumor31 / 263845117
glioma14 / 106883130
head and neck tumor23 / 136302168
kidney tumor2 / 6895929
leukemia2 / 9584220
liver tumor12 / 96359124
lung tumor3 / 10312729
lymphoma0 / 717550 
non-neoplasia7 / 9725071
normal344 / 3360307102
ovarian tumor2 / 7668226
pancreatic tumor13 / 104616124
primitive neuroectodermal tumor of the CNS11 / 12568087
prostate cancer8 / 10268077
retinoblastoma0 / 463560 
skin tumor7 / 12494956
soft tissue/muscle tissue tumor2 / 12519115
uterine tumor3 / 9025733
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue2 / 13106152
adrenal gland1 / 3319730
ascites2 / 4001549
bladder7 / 29757235
blood5 / 12347840
bone13 / 71655181
bone marrow3 / 4880161
brain75 / 110098968
cervix3 / 4817162
connective tissue27 / 149255180
ear2 / 16212123
embryonic tissue17 / 21572278
esophagus7 / 20209346
eye11 / 21105452
heart6 / 8962666
intestine35 / 234472149
kidney42 / 211777198
larynx1 / 2414541
liver24 / 207743115
lung32 / 33697494
lymph0 / 442700 
lymph node3 / 9161032
mammary gland18 / 153271117
mouth19 / 67052283
muscle2 / 10771518
nerve1 / 1576863
ovary4 / 10205139
pancreas18 / 21481283
parathyroid3 / 20539146
pharynx5 / 41328120
pituitary gland1 / 1658560
placenta27 / 28082596
prostate22 / 189345116
salivary gland1 / 2015549
skin33 / 210574156
spleen6 / 53952111
stomach13 / 96619134
testis12 / 33044236
thymus9 / 81131110
thyroid2 / 4747342
tonsil1 / 1699958
trachea12 / 52413228
umbilical cord2 / 13680146
uterus35 / 232878150
vascular16 / 51780308
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 217892_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts64.25
Adipocyte318.8
AdrenalCortex11.55
Adrenalgland11.7
Amygdala8.65
Appendix18.95
AtrioventricularNode6.45
BDCA4+_DentriticCells6.55
Bonemarrow8.3
BronchialEpithelialCells714.75
CD105+_Endothelial3.45
CD14+_Monocytes4.8
CD19+_BCells(neg._sel.)6.7
CD33+_Myeloid6.85
CD34+16.05
CD4+_Tcells10.4
CD56+_NKCells16.55
CD71+_EarlyErythroid2.95
CD8+_Tcells7.85
CardiacMyocytes42
Caudatenucleus7.95
Cerebellum10
CerebellumPeduncles16.2
CiliaryGanglion9.65
CingulateCortex8.6
Colorectaladenocarcinoma11.45
DorsalRootGanglion7.25
FetalThyroid10.6
Fetalbrain9.95
Fetalliver8.15
Fetallung39.8
GlobusPallidus5.55
Heart10.4
Hypothalamus10.7
Kidney7.1
Leukemia_chronicMyelogenousK-5627.9
Leukemia_promyelocytic-HL-607.4
Leukemialymphoblastic(MOLT-4)7.05
Liver10.75
Lung9.55
Lymphnode36.9
Lymphoma_burkitts(Daudi)11.05
Lymphoma_burkitts(Raji)11.65
MedullaOblongata8.7
OccipitalLobe7.85
OlfactoryBulb11.4
Ovary15.15
Pancreas17.9
PancreaticIslet32.85
ParietalLobe7.8
Pituitary33.35
Placenta12.2
Pons8.2
PrefrontalCortex10.25
Prostate15.95
Salivarygland92
SkeletalMuscle8.25
Skin9.85
SmoothMuscle377.4
Spinalcord14.25
SubthalamicNucleus7.65
SuperiorCervicalGanglion10.05
TemporalLobe7.9
Testis7.05
TestisGermCell15.05
TestisIntersitial10.85
TestisLeydigCell8.55
TestisSeminiferousTubule7.5
Thalamus8.6
Thymus7
Thyroid35.6
Tongue10.5
Tonsil15.9
Trachea52
TrigeminalGanglion8.45
Uterus50.2
UterusCorpus35.75
WholeBlood9.25
Wholebrain5.15
colon167.35
pineal_day8.24
pineal_night8.72
retina13.375
small_intestine62.25
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P151267
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.19 ± 0.64
Basal Forebrain6.91 ± 0.26
Basal Part of Pons7.23 ± 0.34
Cerebellar Cortex7.24 ± 0.35
Cerebellar Nuclei7.26 ± 0.47
Claustrum5.5 ± 0.89
Epithalamus6.01 ± 0.69
Frontal Lobe6.56 ± 0.55
Globus Pallidus6.94 ± 0.84
Hypothalamus6.61 ± 0.71
Insula6.53 ± 0.33
Limbic Lobe6.23 ± 0.62
Mesencephalon6.47 ± 0.68
Myelencephalon6.47 ± 0.66
Occipital Lobe6.15 ± 0.61
Parietal Lobe6.33 ± 0.59
Pontine Tegmentum6.44 ± 0.58
Striatum6.78 ± 0.87
Subthalamus6.72 ± 0.24
Temporal Lobe6.26 ± 0.48
Thalamus6.62 ± 0.56
White Matter8.31 ± 0.89
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Lima1CBCerebellum28.06
42.28
Lima1CTXCerebral cortex91.31
72.91
Lima1HIPHippocampal region60.9
73.98
Lima1HPFHippocampal formation77.22
81.61
Lima1HYHypothalamus35.74
27.12
Lima1LSXLateral septal complex34.2
26.64
Lima1MBMidbrain27.63
28.34
Lima1MYMedulla30.56
38.81
Lima1OLFOlfactory bulb73.22
69.95
Lima1PPons32.96
37.68
Lima1PALPallidum31.24
28.43
Lima1RHPRetrohippocampal region100
98.54
Lima1sAMYStriatum-like amygdalar nuclei58.14
45.54
Lima1STRStriatum51.02
39.23
Lima1STRdStriatum dorsal region56.94
44.24
Lima1STRvStriatum ventral region35.2
25.85
Lima1THThalamus75.78
69.43
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
LIMA1_HUMAN_183 14 183 196 ASGKIEKYNVPLNR PRIDE
LIMA1_HUMAN_615 15 615 629 GWSMSEQSEESVGGR PRIDE
PAp00003193 15 615 629 GWSMSEQSEESVGGR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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