AutismKB 2.0

Annotation Detail for ISYNA1


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Basic Information Top
Gene Symbol:ISYNA1 ( INO1,INOS,IPS )
Gene Full Name: inositol-3-phosphate synthase 1
Band: 19p13.11
Quick LinksEntrez ID:51477; OMIM: 611670; Uniprot ID:INO1_HUMAN; ENSEMBL ID: ENSG00000105655; HGNC ID: 29821
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Microarray in BioGPS Top
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  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 222240_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts9.55
Adipocyte10.8
AdrenalCortex16
Adrenalgland12.9
Amygdala11.9
Appendix9.9
AtrioventricularNode8.8
BDCA4+_DentriticCells9.2
Bonemarrow11.95
BronchialEpithelialCells10
CD105+_Endothelial11.1
CD14+_Monocytes9.65
CD19+_BCells(neg._sel.)11.55
CD33+_Myeloid10.75
CD34+96.55
CD4+_Tcells16.8
CD56+_NKCells13.5
CD71+_EarlyErythroid10
CD8+_Tcells12.75
CardiacMyocytes15.25
Caudatenucleus11.4
Cerebellum9.9
CerebellumPeduncles14.45
CiliaryGanglion8.1
CingulateCortex10.6
Colorectaladenocarcinoma15.6
DorsalRootGanglion9.3
FetalThyroid13
Fetalbrain29.65
Fetalliver12.45
Fetallung20.45
GlobusPallidus7.95
Heart26.05
Hypothalamus16
Kidney21.25
Leukemia_chronicMyelogenousK-56256.55
Leukemia_promyelocytic-HL-608.45
Leukemialymphoblastic(MOLT-4)9.95
Liver17.15
Lung17.75
Lymphnode12.8
Lymphoma_burkitts(Daudi)12.25
Lymphoma_burkitts(Raji)16.3
MedullaOblongata8.55
OccipitalLobe11.3
OlfactoryBulb18.1
Ovary9.95
Pancreas9.8
PancreaticIslet13.75
ParietalLobe13.2
Pituitary14.4
Placenta187.45
Pons10.75
PrefrontalCortex15.5
Prostate20.45
Salivarygland7.65
SkeletalMuscle13.2
Skin9.4
SmoothMuscle11.3
Spinalcord13.15
SubthalamicNucleus9.15
SuperiorCervicalGanglion13.55
TemporalLobe9.85
Testis268.7
TestisGermCell893.15
TestisIntersitial122.85
TestisLeydigCell84.45
TestisSeminiferousTubule191.6
Thalamus12.7
Thymus9.5
Thyroid15.65
Tongue9.45
Tonsil11.95
Trachea10.3
TrigeminalGanglion11.95
Uterus23.35
UterusCorpus11.85
WholeBlood8.4
Wholebrain10.4
colon11.7
pineal_day14.9
pineal_night24.26
retina26.25
small_intestine9.1
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_16668_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.96 ± 0.32
Basal Forebrain5.19 ± 0.44
Basal Part of Pons4.85 ± 0.53
Cerebellar Cortex4.74 ± 0.5
Cerebellar Nuclei5.1 ± 0.57
Claustrum4.54 ± 0.96
Epithalamus5.89 ± 0.5
Frontal Lobe5.13 ± 0.56
Globus Pallidus5.23 ± 0.39
Hypothalamus5.6 ± 0.62
Insula5.26 ± 0.36
Limbic Lobe4.82 ± 0.56
Mesencephalon5.08 ± 0.65
Myelencephalon5.15 ± 0.5
Occipital Lobe4.86 ± 0.58
Parietal Lobe4.82 ± 0.52
Pontine Tegmentum5.12 ± 0.55
Striatum5.64 ± 0.45
Subthalamus5.01 ± 0.76
Temporal Lobe5.13 ± 0.48
Thalamus5.16 ± 0.58
White Matter3.8 ± 0.83
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Isyna1CBCerebellum21.79
32.6
Isyna1CTXCerebral cortex24.45
18.02
Isyna1HIPHippocampal region14.59
16.85
Isyna1HPFHippocampal formation15.87
15.93
Isyna1HYHypothalamus41.39
33.26
Isyna1LSXLateral septal complex53.46
38.68
Isyna1MBMidbrain31.98
31.59
Isyna1MYMedulla35.19
38.31
Isyna1OLFOlfactory bulb32.62
24.76
Isyna1PPons38.19
42.98
Isyna1PALPallidum41.49
35.4
Isyna1RHPRetrohippocampal region17.83
14.3
Isyna1sAMYStriatum-like amygdalar nuclei36.96
30.32
Isyna1STRStriatum57.29
40.95
Isyna1STRdStriatum dorsal region55.06
38.73
Isyna1STRvStriatum ventral region75.2
51.58
Isyna1THThalamus28.33
25.2
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00002336 17 234 250 FCEVIPGLNDTAENLLR Peptide Atlas

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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018