AutismKB 2.0

Annotation Detail for PTPLAD1


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Basic Information Top
Gene Symbol:PTPLAD1 ( B-IND1,FLJ90376,HACD3,HSPC121 )
Gene Full Name: protein tyrosine phosphatase-like A domain containing 1
Band: 15q22.2
Quick LinksEntrez ID:51495; OMIM: NA; Uniprot ID:HACD3_HUMAN; ENSEMBL ID: ENSG00000074696; HGNC ID:
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body14 / 70761197
blastocyst15 / 62319240
fetus60 / 564012106
neonate6 / 31097192
infant9 / 23620381
juvenile16 / 55556287
adult237 / 1939121122
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor8 / 12794625
bladder carcinoma1 / 1747557
breast (mammary gland) tumor9 / 9417895
cervical tumor7 / 34366203
chondrosarcoma16 / 82823193
colorectal tumor7 / 11424661
esophageal tumor4 / 17290231
gastrointestinal tumor13 / 119369108
germ cell tumor90 / 263845341
glioma9 / 10688384
head and neck tumor16 / 136302117
kidney tumor14 / 68959203
leukemia9 / 9584293
liver tumor18 / 96359186
lung tumor9 / 10312787
lymphoma3 / 7175541
non-neoplasia8 / 9725082
normal409 / 3360307121
ovarian tumor9 / 76682117
pancreatic tumor14 / 104616133
primitive neuroectodermal tumor of the CNS20 / 125680159
prostate cancer11 / 102680107
retinoblastoma12 / 46356258
skin tumor10 / 12494980
soft tissue/muscle tissue tumor8 / 12519163
uterine tumor14 / 90257155
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland10 / 33197301
ascites7 / 40015174
bladder3 / 29757100
blood11 / 12347889
bone12 / 71655167
bone marrow6 / 48801122
brain202 / 1100989183
cervix7 / 48171145
connective tissue13 / 14925587
ear2 / 16212123
embryonic tissue44 / 215722203
esophagus4 / 20209197
eye24 / 211054113
heart8 / 8962689
intestine22 / 23447293
kidney29 / 211777136
larynx1 / 2414541
liver27 / 207743129
lung29 / 33697486
lymph0 / 442700 
lymph node7 / 9161076
mammary gland16 / 153271104
mouth10 / 67052149
muscle5 / 10771546
nerve1 / 1576863
ovary9 / 10205188
pancreas51 / 214812237
parathyroid1 / 2053948
pharynx1 / 4132824
pituitary gland5 / 16585301
placenta31 / 280825110
prostate21 / 189345110
salivary gland0 / 201550 
skin24 / 210574113
spleen4 / 5395274
stomach7 / 9661972
testis112 / 330442338
thymus2 / 8113124
thyroid7 / 47473147
tonsil1 / 1699958
trachea3 / 5241357
umbilical cord0 / 136800 
uterus24 / 232878103
vascular5 / 5178096
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 217777_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts32.15
Adipocyte12
AdrenalCortex7.2
Adrenalgland8.85
Amygdala28.15
Appendix6.95
AtrioventricularNode5.1
BDCA4+_DentriticCells7.45
Bonemarrow6.7
BronchialEpithelialCells20.8
CD105+_Endothelial7
CD14+_Monocytes6.55
CD19+_BCells(neg._sel.)5.65
CD33+_Myeloid7.9
CD34+9.2
CD4+_Tcells6.75
CD56+_NKCells7.35
CD71+_EarlyErythroid7.55
CD8+_Tcells6.65
CardiacMyocytes16.5
Caudatenucleus9.45
Cerebellum6.3
CerebellumPeduncles10.4
CiliaryGanglion4.6
CingulateCortex7.75
Colorectaladenocarcinoma7.2
DorsalRootGanglion5.25
FetalThyroid6.7
Fetalbrain12.25
Fetalliver10.15
Fetallung5.95
GlobusPallidus5.1
Heart8.2
Hypothalamus36.25
Kidney6.9
Leukemia_chronicMyelogenousK-56211.05
Leukemia_promyelocytic-HL-6013.2
Leukemialymphoblastic(MOLT-4)7.5
Liver9.45
Lung7.5
Lymphnode5.95
Lymphoma_burkitts(Daudi)8.7
Lymphoma_burkitts(Raji)8.8
MedullaOblongata13.95
OccipitalLobe32.15
OlfactoryBulb4.6
Ovary4.45
Pancreas4.95
PancreaticIslet15.55
ParietalLobe11.75
Pituitary39.8
Placenta14.4
Pons7.25
PrefrontalCortex14.85
Prostate8.1
Salivarygland5.05
SkeletalMuscle7.95
Skin5.05
SmoothMuscle12.25
Spinalcord12.15
SubthalamicNucleus6.4
SuperiorCervicalGanglion8.15
TemporalLobe6.3
Testis8.5
TestisGermCell5.55
TestisIntersitial5.75
TestisLeydigCell6.9
TestisSeminiferousTubule6
Thalamus12.15
Thymus5.45
Thyroid10.8
Tongue6.8
Tonsil6.45
Trachea6.35
TrigeminalGanglion6.65
Uterus5
UterusCorpus6.15
WholeBlood6.35
Wholebrain10.2
colon11.95
pineal_day8.28
pineal_night9.5
retina11.95
small_intestine15.1
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_4601_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala11.2 ± 0.3
Basal Forebrain11.34 ± 0.18
Basal Part of Pons11.66 ± 0.23
Cerebellar Cortex11.47 ± 0.19
Cerebellar Nuclei11.67 ± 0.24
Claustrum11.29 ± 0.45
Epithalamus11.74 ± 0.3
Frontal Lobe11.7 ± 0.25
Globus Pallidus11.81 ± 0.31
Hypothalamus12.01 ± 0.2
Insula11.75 ± 0.3
Limbic Lobe11.27 ± 0.39
Mesencephalon11.62 ± 0.29
Myelencephalon11.5 ± 0.37
Occipital Lobe11.14 ± 0.45
Parietal Lobe11.56 ± 0.34
Pontine Tegmentum11.61 ± 0.37
Striatum11.17 ± 0.28
Subthalamus12.11 ± 0.23
Temporal Lobe11.62 ± 0.26
Thalamus11.62 ± 0.27
White Matter11.76 ± 0.21
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Ptplad1CBCerebellum20.42
74.81
Ptplad1CTXCerebral cortex98.07
93.86
Ptplad1HIPHippocampal region100
100
Ptplad1HPFHippocampal formation100
100
Ptplad1HYHypothalamus47.83
58.27
Ptplad1LSXLateral septal complex100
100
Ptplad1MBMidbrain47.18
61.28
Ptplad1MYMedulla30
56.8
Ptplad1OLFOlfactory bulb69.13
76.5
Ptplad1PPons30.55
60.37
Ptplad1PALPallidum48.83
57.77
Ptplad1RHPRetrohippocampal region98.18
100
Ptplad1sAMYStriatum-like amygdalar nuclei81.45
77.83
Ptplad1STRStriatum45.48
38.46
Ptplad1STRdStriatum dorsal region41.36
34.28
Ptplad1STRvStriatum ventral region31.74
24.53
Ptplad1THThalamus38.43
41.92
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00002747 22 51 72 GDNVYEFHLEFLDLVKPEPVYK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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