AutismKB 2.0

Annotation Detail for PDE8A


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Basic Information Top
Gene Symbol:PDE8A ( FLJ16150,HsT19550 )
Gene Full Name: phosphodiesterase 8A
Band: 15q25.3
Quick LinksEntrez ID:5151; OMIM: 602972; Uniprot ID:PDE8A_HUMAN; ENSEMBL ID: ENSG00000073417; HGNC ID: 8793
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body2 / 7076128
blastocyst0 / 623190 
fetus32 / 56401256
neonate0 / 310970 
infant0 / 236200 
juvenile3 / 5555653
adult125 / 193912164
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor2 / 12794156
bladder carcinoma3 / 17475171
breast (mammary gland) tumor2 / 9417821
cervical tumor1 / 3436629
chondrosarcoma3 / 8282336
colorectal tumor6 / 11424652
esophageal tumor0 / 172900 
gastrointestinal tumor10 / 11936983
germ cell tumor0 / 2638450 
glioma2 / 10688318
head and neck tumor7 / 13630251
kidney tumor3 / 6895943
leukemia3 / 9584231
liver tumor3 / 9635931
lung tumor6 / 10312758
lymphoma0 / 717550 
non-neoplasia5 / 9725051
normal162 / 336030748
ovarian tumor1 / 7668213
pancreatic tumor3 / 10461628
primitive neuroectodermal tumor of the CNS2 / 12568015
prostate cancer3 / 10268029
retinoblastoma2 / 4635643
skin tumor2 / 12494916
soft tissue/muscle tissue tumor13 / 125191103
uterine tumor8 / 9025788
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland2 / 3319760
ascites1 / 4001524
bladder8 / 29757268
blood2 / 12347816
bone6 / 7165583
bone marrow1 / 4880120
brain57 / 110098951
cervix1 / 4817120
connective tissue1 / 1492556
ear2 / 16212123
embryonic tissue5 / 21572223
esophagus0 / 202090 
eye5 / 21105423
heart7 / 8962678
intestine8 / 23447234
kidney14 / 21177766
larynx6 / 24145248
liver21 / 207743101
lung13 / 33697438
lymph0 / 442700 
lymph node4 / 9161043
mammary gland9 / 15327158
mouth1 / 6705214
muscle5 / 10771546
nerve2 / 15768126
ovary2 / 10205119
pancreas12 / 21481255
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta11 / 28082539
prostate7 / 18934536
salivary gland1 / 2015549
skin2 / 2105749
spleen1 / 5395218
stomach10 / 96619103
testis14 / 33044242
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus12 / 23287851
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 212522_at
Cell line Expression level Expression bar
721_B_lymphoblasts156.6
Adipocyte37.7
AdrenalCortex132.35
Adrenalgland32.85
Amygdala90.35
Appendix21.4
AtrioventricularNode13.4
BDCA4+_DentriticCells17.3
Bonemarrow15.1
BronchialEpithelialCells28.15
CD105+_Endothelial16.35
CD14+_Monocytes32.8
CD19+_BCells(neg._sel.)30.9
CD33+_Myeloid62.65
CD34+18
CD4+_Tcells41.85
CD56+_NKCells27.9
CD71+_EarlyErythroid12.65
CD8+_Tcells37.3
CardiacMyocytes23.6
Caudatenucleus100.05
Cerebellum10.8
CerebellumPeduncles19.6
CiliaryGanglion22.15
CingulateCortex43.3
Colorectaladenocarcinoma51.05
DorsalRootGanglion21.8
FetalThyroid27.8
Fetalbrain24.95
Fetalliver25.8
Fetallung47.75
GlobusPallidus16.3
Heart17.35
Hypothalamus177.55
Kidney16
Leukemia_chronicMyelogenousK-56244.4
Leukemia_promyelocytic-HL-6028.4
Leukemialymphoblastic(MOLT-4)14.95
Liver21.25
Lung15.6
Lymphnode57.6
Lymphoma_burkitts(Daudi)21.45
Lymphoma_burkitts(Raji)30.85
MedullaOblongata48.75
OccipitalLobe103.4
OlfactoryBulb25.25
Ovary18.15
Pancreas24.1
PancreaticIslet35.8
ParietalLobe96.85
Pituitary25
Placenta18.95
Pons16.6
PrefrontalCortex102.7
Prostate28.75
Salivarygland19.95
SkeletalMuscle19.35
Skin18.25
SmoothMuscle76.9
Spinalcord117.85
SubthalamicNucleus22.35
SuperiorCervicalGanglion17.4
TemporalLobe13.1
Testis17.05
TestisGermCell46.25
TestisIntersitial20.45
TestisLeydigCell24.5
TestisSeminiferousTubule21.3
Thalamus106.65
Thymus10.1
Thyroid42.4
Tongue19.3
Tonsil16.3
Trachea20.05
TrigeminalGanglion25.5
Uterus57.35
UterusCorpus26.6
WholeBlood16.4
Wholebrain19.5
colon144.2
pineal_day56.32
pineal_night61.68
retina81.925
small_intestine89.85
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_12461_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.86 ± 0.77
Basal Forebrain6.67 ± 0.42
Basal Part of Pons6 ± 0.45
Cerebellar Cortex5.42 ± 0.32
Cerebellar Nuclei6.94 ± 0.47
Claustrum6.07 ± 0.43
Epithalamus6.09 ± 0.52
Frontal Lobe5.88 ± 0.72
Globus Pallidus7.7 ± 0.34
Hypothalamus5.92 ± 0.52
Insula5.56 ± 0.46
Limbic Lobe5.85 ± 0.73
Mesencephalon6.32 ± 0.72
Myelencephalon6.19 ± 0.64
Occipital Lobe6.22 ± 0.59
Parietal Lobe6.21 ± 0.69
Pontine Tegmentum6.24 ± 0.59
Striatum6.89 ± 0.62
Subthalamus6.16 ± 0.48
Temporal Lobe5.92 ± 0.57
Thalamus6.46 ± 0.47
White Matter8.53 ± 0.48
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Pde8aCBCerebellum1.38
1.74
Pde8aCTXCerebral cortex1.46
1.48
Pde8aHIPHippocampal region0.87
1.02
Pde8aHPFHippocampal formation0.72
0.82
Pde8aHYHypothalamus0.59
0.47
Pde8aLSXLateral septal complex0.07
0.13
Pde8aMBMidbrain1.4
1.59
Pde8aMYMedulla2.69
2.68
Pde8aOLFOlfactory bulb2.1
2.53
Pde8aPPons1.39
1.51
Pde8aPALPallidum0.8
0.62
Pde8aRHPRetrohippocampal region0.45
0.54
Pde8asAMYStriatum-like amygdalar nuclei0.18
0.18
Pde8aSTRStriatum1.01
0.68
Pde8aSTRdStriatum dorsal region1.15
0.78
Pde8aSTRvStriatum ventral region1.36
0.82
Pde8aTHThalamus1.14
0.87
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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