AutismKB 2.0

Annotation Detail for DTL


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Basic Information Top
Gene Symbol:DTL ( CDT2,DCAF2,L2DTL,RAMP )
Gene Full Name: denticleless homolog (Drosophila)
Band: 1q32.3
Quick LinksEntrez ID:51514; OMIM: 610617; Uniprot ID:DTL_HUMAN; ENSEMBL ID: ENSG00000143476; HGNC ID: 30288
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst9 / 62319144
fetus22 / 56401239
neonate2 / 3109764
infant0 / 236200 
juvenile8 / 55556143
adult38 / 193912119
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor4 / 9417842
cervical tumor4 / 34366116
chondrosarcoma1 / 8282312
colorectal tumor1 / 1142468
esophageal tumor0 / 172900 
gastrointestinal tumor5 / 11936941
germ cell tumor29 / 263845109
glioma0 / 1068830 
head and neck tumor2 / 13630214
kidney tumor0 / 689590 
leukemia15 / 95842156
liver tumor4 / 9635941
lung tumor1 / 1031279
lymphoma14 / 71755195
non-neoplasia0 / 972500 
normal72 / 336030721
ovarian tumor2 / 7668226
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS3 / 12568023
prostate cancer1 / 1026809
retinoblastoma5 / 46356107
skin tumor5 / 12494940
soft tissue/muscle tissue tumor6 / 12519147
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites4 / 4001599
bladder2 / 2975767
blood14 / 123478113
bone1 / 7165513
bone marrow4 / 4880181
brain7 / 11009896
cervix4 / 4817183
connective tissue2 / 14925513
ear0 / 162120 
embryonic tissue13 / 21572260
esophagus0 / 202090 
eye7 / 21105433
heart1 / 8962611
intestine4 / 23447217
kidney2 / 2117779
larynx1 / 2414541
liver7 / 20774333
lung2 / 3369745
lymph5 / 44270112
lymph node9 / 9161098
mammary gland5 / 15327132
mouth1 / 6705214
muscle0 / 1077150 
nerve1 / 1576863
ovary3 / 10205129
pancreas1 / 2148124
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta8 / 28082528
prostate1 / 1893455
salivary gland0 / 201550 
skin6 / 21057428
spleen1 / 5395218
stomach0 / 966190 
testis49 / 330442148
thymus8 / 8113198
thyroid0 / 474730 
tonsil0 / 169990 
trachea2 / 5241338
umbilical cord1 / 1368073
uterus7 / 23287830
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 218585_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts534.25
Adipocyte8.35
AdrenalCortex11.4
Adrenalgland7.45
Amygdala7.7
Appendix10.95
AtrioventricularNode9.25
BDCA4+_DentriticCells9.4
Bonemarrow14.2
BronchialEpithelialCells10.15
CD105+_Endothelial720.05
CD14+_Monocytes8.55
CD19+_BCells(neg._sel.)9.2
CD33+_Myeloid12.8
CD34+452.7
CD4+_Tcells7.8
CD56+_NKCells9.05
CD71+_EarlyErythroid307.75
CD8+_Tcells6.85
CardiacMyocytes16.45
Caudatenucleus7.7
Cerebellum6.8
CerebellumPeduncles10.35
CiliaryGanglion8.3
CingulateCortex9
Colorectaladenocarcinoma9.7
DorsalRootGanglion8.15
FetalThyroid8.55
Fetalbrain8.05
Fetalliver27.4
Fetallung8.9
GlobusPallidus6.4
Heart15.45
Hypothalamus7.9
Kidney8.2
Leukemia_chronicMyelogenousK-56275.1
Leukemia_promyelocytic-HL-6037.3
Leukemialymphoblastic(MOLT-4)103.5
Liver13.65
Lung8.7
Lymphnode6.4
Lymphoma_burkitts(Daudi)25.4
Lymphoma_burkitts(Raji)15.35
MedullaOblongata7.7
OccipitalLobe7.15
OlfactoryBulb6.7
Ovary6.85
Pancreas7.3
PancreaticIslet8.9
ParietalLobe9.65
Pituitary9.9
Placenta8.35
Pons8.55
PrefrontalCortex9.05
Prostate9.3
Salivarygland7.45
SkeletalMuscle20.5
Skin8.8
SmoothMuscle9.4
Spinalcord8.5
SubthalamicNucleus8.1
SuperiorCervicalGanglion15.9
TemporalLobe8.1
Testis10.3
TestisGermCell11.85
TestisIntersitial7.85
TestisLeydigCell12.05
TestisSeminiferousTubule12.2
Thalamus8.75
Thymus11.8
Thyroid9.2
Tongue10.25
Tonsil10.45
Trachea6.95
TrigeminalGanglion11
Uterus6.45
UterusCorpus9.65
WholeBlood8.95
Wholebrain6.05
colon9.95
pineal_day9.66
pineal_night9.42
retina9.825
small_intestine11.7
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_15254_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.23 ± 1.02
Basal Forebrain1.67 ± 0.21
Basal Part of Pons1.72 ± 0.97
Cerebellar Cortex1.48 ± 0.76
Cerebellar Nuclei1.89 ± 0.68
Claustrum2.69 ± 0.85
Epithalamus1.2 ± 0.83
Frontal Lobe1.71 ± 0.82
Globus Pallidus2.19 ± 0.49
Hypothalamus1.74 ± 0.67
Insula1.64 ± 0.87
Limbic Lobe1.74 ± 0.83
Mesencephalon1.81 ± 0.84
Myelencephalon1.73 ± 0.83
Occipital Lobe1.62 ± 0.65
Parietal Lobe1.65 ± 0.9
Pontine Tegmentum1.75 ± 0.82
Striatum1.85 ± 0.91
Subthalamus1.61 ± 0.76
Temporal Lobe1.54 ± 0.86
Thalamus1.7 ± 0.74
White Matter1.94 ± 0.41
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
DtlCBCerebellum0
0
DtlCTXCerebral cortex0
0
DtlHIPHippocampal region0
0
DtlHPFHippocampal formation0
0
DtlHYHypothalamus0
0
DtlLSXLateral septal complex0
0
DtlMBMidbrain0
0
DtlMYMedulla0
0
DtlOLFOlfactory bulb0
0
DtlPPons0
0
DtlPALPallidum0
0
DtlRHPRetrohippocampal region0
0
DtlsAMYStriatum-like amygdalar nuclei0
0
DtlSTRStriatum0
0
DtlSTRdStriatum dorsal region0
0
DtlSTRvStriatum ventral region0
0
DtlTHThalamus0
0
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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